Interaction of Metal Ions With 3,3-Dimethylglutarimide

Abstract

Interaction of the biologically active ligand 3,3-dimethylglutarimide with a series of metal ions has been investigated by a potentiometric method. Acid dissociation constants of the ligand (L) and stability constants for the formation of 1:l (metal to ligand) complexes with Cu(II), Ni(II), Zn(II), Hg(II), Be(I1) and Ag(1) have been determined in aqueous solution at 25.0'C and 0.1 M (KNO,) ionic strength. It has been shown that silver(1) and mercury(I1) ions form two types of complexes, ML and ML, in a stepwise manner. It suggested that in the ML, complex (where M = Ag, Hg), a linear N-M-N bond is formed through the two deprotonated nitrogen atoms of glutarimide rings.

Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound

“…The structural features and physiochemical properties of the glutarimide moiety is remarkably similar to the uracil derivatives. Therefore, it interacts with specific receptors involved in transport of uracil and thymine nucleosides across biological membranes [ 28 , 29 ]. Being a constituent of a large number of other important compounds, the glutarimide moeity possesses a broad spectrum of pharmacological and anticancer properties [ 2 , 30 , 31 ].…”

Glutarimide: a carrier transporting drug through cell membranes

“…A potentiometric study on interaction of glutarimide derivatives with metal ions, in aqueous solution, has shown that the stability constants of the complexes are similar to those of the corresponding metal complexes of uracil and thymine. It has been concluded that glutarimide and pyrimidine bases may have similar binding sites (17,18). 4.…”