Interaction of Maternal and Neonatal Cells in Mixed-Lymphocyte Cultures

Lawler, SylviaD.; Ukaejiofo, Ernest O; Reeves, Brian

doi:10.1016/s0140-6736(75)92663-x

Cited by 90 publications

(39 citation statements)

References 6 publications

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“…Studies currently in progress indicate that the newborn non-T cells which incorporate thymidine lack T cell antigen (OKT 3, 4,8) but are positive for surface Ia antigens. As would be predicted from our interpretation, Lawler et al (16) did not find an excess of mitoses of one or other sex when newbornnewborn 2-way MLC were studied.…”

Section: Discussionsupporting

confidence: 87%

“…The report by Lawler et al (16) that newborn T cells were stimulated to become suppressor cells in MLC was based on their finding a higher frequency of dividing newborn cells (by karyotype analysis) in 2-way newborn-adult MLC and not on any conventional assay for suppression. We considered that their result might be due to proliferation by newborn non-T cells rather than suppression of adult T cells.…”

Section: Discussionmentioning

confidence: 99%

“…Lawler et 01. (16)'s report of suppression of maternal T cell proliferation in 2-way MLC suggests that antigen stimulus may sometimes be sufficient to trigger suppression by newborn T cells. To explore this issue.…”

Section: Response Of Human Newborn Lymphocytes Tomentioning

confidence: 99%

“…Unseparated cultures were included for comparison with Lawler et a/. (16) results. Our results (Table 4) show that mitoses of the newborn karyotype predominate in 2-way MLC in which the stimulator cells are not irradiated.…”

Section: Origin Of Dividing Cells In Newborn-adult 2-way Mlcmentioning

confidence: 99%

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Response of Human Newborn Lymphocytes to Alloantigen: Lack of Evidence for Suppression Induction

Hayward

Malmberg

1984

Pediatr Res

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Response Of Human Newborn Lymphocytes Tomentioning

confidence: 99%

Section: Origin Of Dividing Cells In Newborn-adult 2-way Mlcmentioning

confidence: 99%

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Response of Human Newborn Lymphocytes to Alloantigen: Lack of Evidence for Suppression Induction

Hayward

Malmberg

1984

Pediatr Res

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“…Received for publication 2 April 1979 anid in revised form 29 May 1979. 990 blocking factors (3)(4)(5)(6) as well as changes in lymphocyte interactions (7,8). One of the most interesting features of the newborn state revolves around the apparent impairment ofde novo immunoglobin synthesis in the face of normal proportions and numbers of bone marrow-derived (B) cells with surface immunoglobulin (Ig).…”

Section: Introductionmentioning

confidence: 99%

Studies of human cord blood and adult lymphocyte interactions with in vitro immunoglobulin production.

Morito¹,

Bankhurst²,

Williams³

1979

J. Clin. Invest.

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Peripheral blood t‐cell subpopulations in the very low birth weight (less than 1,500‐g) infant

Ballow

et al. 1987

American J Hematol

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The development of monoclonal antibodies to cell-surface antigens has provided method for characterizing distinct subpopulations of T-cells. In the present study we have quantified peripheral blood T-cell subpopulations in premature infants born weighing less than 1,500 g (1123 +/- 223 g) and ranging in gestational age from 25 to 32 weeks. The relative proportion of T4 cells in the very low birth weight (VLBW) infants was markedly higher at 1 week and 1 month of age (mean +/- SEM; 67.5 +/- 4.1 and 59.2 +/- 1.6) than in adult controls (47.2 +/- 1.5). The percentage of T4 cells remained elevated until 6 months of age, when it decreased to a level comparable to that in adults. In contrast, the proportion of T8 cells was significantly lower than the adult level at 1 week and 1 month of age. The T4/T8 ratio in the VLBW infants was higher at 1 week (4.3 +/- 0.5) and 1 month (3.5 +/- 0.2) than in adult controls (2.0 +/- 0.1). Thereafter, the T4/T8 ratio decreased but was still significantly higher than that in adult controls at 6 months of age (2.6 +/- 0.2). The absolute numbers of total T-cells (T3) and T8 and T4 cells were significantly higher in VLBW infants. The numbers of T8 cells were significantly lower in the first month of life than at 3-6 months of age. These alterations in the T-cell subsets in the first 6 months of life suggest that postnatal T-cell phenotypic changes in VLBW infants may parallel the T-cell ontogenetic process which occurs during the last trimester of pregnancy in full-term infants.

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Interaction of Maternal and Neonatal Cells in Mixed-Lymphocyte Cultures

Cited by 90 publications

References 6 publications

Response of Human Newborn Lymphocytes to Alloantigen: Lack of Evidence for Suppression Induction

Response of Human Newborn Lymphocytes to Alloantigen: Lack of Evidence for Suppression Induction

Studies of human cord blood and adult lymphocyte interactions with in vitro immunoglobulin production.

Peripheral blood t‐cell subpopulations in the very low birth weight (less than 1,500‐g) infant

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