“…DOX has the ability to modify the chemical composition, structure, and function of biological membranes, mainly at the mitochondrial, fundamentally due to the peroxidation of membrane lipids, leading to the release of protein and cholesterol from the cytosol into the bloodstream (Chen et al, 2007). Malabade et al (2014) found that doxorubicin significantly increases the level of triglyceride, HDL, LDL, VLDL. Injury induces by DOX could be mainly mediated through the free radical generation and iron-dependent oxidative damage to the biological macromolecules and membrane lipid peroxidation).…”