Interaction of ions and connective tissue

Extracellular Electrolyte Balance and Aging

“…Connective tissues differ with respect to colloidal composition, states of aggregation, and electrolyte composition [9][10][11][12][13]. They also vary in physiological responses and adaptations, and with respect to growth and aging.…”

Submicroscopic Morphology of Connective Tissue Ground Substance with Particular Regard to Fibrillogenesis and Aging

“…It appears organized as submicroscopic vacuoles (a more aqueous phase) enclosed in a denser material (a less aqueous phase). This two-phase organization, regarded as being in a thermo dynamic state of equilibrium, appears to represent the morphological substratum of the two-phase system hypothicatcd by Josephs, Engel and Catchpole (Joseph et al, 1952(Joseph et al, , 1954Engel et ah, 1954) on thermodynamic grounds to account for their electrochemical measurements of various kinds and states of connective tissues. Before fibrils appear and in early stages of fibrillogenesis the sub microscopic vacuoles are large, while in later stages they are smaller.…”

Ageing of Skin

“…The experimental method as applied to animal connective tissues has been describ ed (2,5,6). An adaptation to human skin has also been reported (1).…”