Interaction of Intestinal Disaccharidases with Phospholipids
Chinnaswamy Tiruppathi,
David H. Alpers,
Bellur Seetharam
Abstract:Although the rat intestinal brush border disaccharidases are the most easily solubilized protein components, the nature of the lipid‐protein interactions in the membrane is incompletely understood. Phospholipid vesicles were prepared using the lecithin fraction from brush border membranes and synthetic lecithins. Addition of cholesterol to brush border lecithins enhanced the binding of disaccharidases, but not of alkaline phosphatase. The addition of cholesterol to synthetic lecithin vesicles enhanced the bind… Show more
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