Interaction of Interleukin-16 Genotypes With Betel Quid Chewing Behavior on Oral Cancer in Taiwan

Shih, Liang‐Chun; Chang, Wen‐Yu; Lee, Hsu‐Tung; Wang, Yun-Chi; Wang, Zhihong; Chao, Che‐Yi; Yu, Chien‐Chih; Lin, Hui‐Yi; Shen, Te Chun; Kuo, Ching-Ming; Tsai, Chia-Wen; Bau, Da‐Tian

doi:10.21873/invivo.11969

Cited by 11 publications

(10 citation statements)

References 17 publications

(22 reference statements)

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“…In agreement with our results, two other metaanalyses published in 2014 did not find a significant association between rs4778889 and rs4072111 of IL16 and cancer. However, these same studies observed a statistically significant association between rs11556218 and cancer, an association observed in our study with the addition of new studies published after these metaanalyses results [41][42][43][44]. The SNP rs11556218, consisting of a substitution of the T nucleotide by a G, is located in the exon region of the gene and results in a modification of the pro-IL-16 PDZ2 domain (IL-16 isoform with 631 amino acids) and npro-IL-16 (neuronal IL-16 isoform with 1331 amino acids).…”

Section: Discussionsupporting

confidence: 63%

Association of functional IL16 polymorphisms with cancer and cardiovascular disease: a meta-analysis

et al. 2020

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Introduction: Interleukin-16 (IL-16) is a chemotactic cytokine that is found to increase in Cancer and cardiovascular diseases (CVD). Single nucleotide polymorphisms (SNPs) in IL16 were associated with diseases. Thus, we conducted a systematic review and meta-analysis to evaluate possible associations between IL16 rs4778889, rs11556218, rs4072111, and rs1131445 SNPs and the risk for cancer or CVD. Materials and Methods: This study was performed according to the PRISMA statement. Medline, Web of Science, and Scopus databases were systematically reviewed, and a meta-analysis was conducted. Results: The analysis comprised 6386 individuals with cancer and 2415 with CVD. The SNP rs11556218 was significantly associated with an increased risk for cancer in Chinese in different genetic inheritance models. Also, to the best of our knowledge, this is the first meta-analysis to show an association of rs4778889 with an increased risk of gastric cancer and rs11556218 with an increased risk of CVD in Chinese. Conclusions: Our meta-analysis suggested that the SNPs rs11556218 and rs4778889 of IL16 were associated with an increased risk for cancer in Chinese and rs11556218 with increased risk for CVD in Chinese, highlighting the need for further studies on the impact of these polymorphisms on cancer treatment and surveillance.

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Section: Discussionsupporting

confidence: 63%

Association of functional IL16 polymorphisms with cancer and cardiovascular disease: a meta-analysis

et al. 2020

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“…PDCD6 genotyping. Total DNA from the blood of each participant was extracted using the QIAamp Blood Mini Kit (Blossom, Taipei, Taiwan, ROC) and further processed as previously published (25)(26)(27). Briefly, the polymerase chain reaction (PCR) programs were set as: one cycle at 94˚C for 5 min; 35 cycles of 94˚C for 30 s, 55˚C for 30 s and 72˚C for 30 s; and a final elongation at 72˚C for 10 min.…”

Section: Methodsmentioning

confidence: 99%

The Contribution of PDCD6 Polymorphisms to Oral Cancer Risk

Shih

Chang

et al. 2022

Cancer Genomics Proteomics

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Background/Aim: Programmed cell death 6 (PDCD6) is up-regulated and highly expressed in early apoptotic cells. In several types of cancer, such as cervical, breast and lung cancers, the association of PDCD6 genotypes have been investigated. However, the contribution of PDCD6 variant genotypes to oral cancer has never been examined. The current study aimed to evaluate the contribution of the PDCD6 rs4957014 and rs3756712 genotypes to the risk of oral cancer in Taiwan. Patients and Methods: The contribution of PDCD6 genotypes to oral cancer risk was examined among 958 patients with lung cancer and 958 ageand sex-matched healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The data showed that the hetero-variant GT and homo-variant GG genotypes of PDCD6 rs4957014 were associated with a decreased risk of oral cancer [odds ratio (OR)=0.81 and 0.39, 95% confidence interval (CI)=0.67-0.97 and 0.27-0.56, respectively]. The recessive and dominant models also showed that G carriers have protective effects (OR=0.43 and 0.72, 95% CI=0.30-0.61 and 0.61-0.87, respectively). The analysis of allelic frequency distributions showed that the G allele of PDCD6 rs4957014 was associated with reduced oral cancer risk (OR=0.71, 95% CI=0.62-0.82). There was no significant association between any PDCD6 rs3756712 genotype and oral cancer risk. In addition, the GG genotype at PDCD6 rs4957014 significantly decreased the risk of oral cancer among both males (adjusted OR=0.31,. Furthermore, the GG genotype at PDCD6 rs4957014 significantly decreased the risk of oral cancer among smokers (adjusted OR=0.35, 95% CI=0.22-0.58), alcohol drinkers (adjusted OR=0.33, 95% CI=0.18-0.49), non-betel quid chewers (adjusted OR=0.33, 95% CI=0.17-0.81), betel quid chewers (adjusted OR=0.34, 95% CI=0.21-0.59), but not among never-smokers and non-alcohol drinkers. Conclusion: The G allele carriers of PDCD6 rs4957014 may have protective effects on oral cancer risk and serve as a practical marker for early detection of oral cancer in Taiwan.Oral cancer is the fourth most common male cancer and the fourth leading cause of male cancer death in Taiwan, where the density of oral cancer is the top of the world (1-3). There are already several environmental factors known to contribute to the development of oral cancer, including 456 *These Authors contributed equally to this study.

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“…Oral cancer XPC genotyping methodology. DNA from all participants was processed in typical polymerase chain reaction (PCR) processes as in our previous papers (25)(26)(27). The sequences of designed forward and reverse primers, corresponding restriction enzymes (New England BioLabs, Ipswich, MA, USA) and sizes of PCR products after enzyme digestion for oral cancer XPC genotyping identification are shown in Table II.…”

Section: Methodsmentioning

confidence: 99%

Interaction of DNA Repair Gene XPC With Smoking and Betel Quid Chewing Behaviors of Oral Cancer

Chang

Shih

et al. 2021

Cancer Genomics Proteomics

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Background/Aim: Xeroderma pigmentosum complementation group C (XPC) is reported to play important roles in DNA integrity and genomic instability, however, the contribution of XPC to oral carcinogenesis is largely uncertain. Therefore, we aimed at examining the contribution of XPC genotypes to oral cancer. Materials and Methods: The genotypes of XPC rs2228001 and rs2228000 were examined among 958 oral cancer patients and 958 control subjects by polymerase chain reaction-restriction fragment length polymorphism methodology and corresponding DNA repair capacity was checked. Results: First, the percentages of XPC rs2228001 AC and CC were higher among oral cancer patients than controls. Second, no significant association was observed regarding XPC rs2228000. Third, there was a synergistic influence of smoking and betel quid chewing behaviors and XPC rs2228001 genotype on oral cancer risk. Last, functional experiments showed DNA repair capacity was lower for AC/CC carriers than AA carriers. Conclusion: XPC rs2228001 C allele, which was associated with decreased DNA repair capacity, may interact with smoking and betel quid chewing behaviors on oral cancer risk.Oral cancer is the tenth most common cancer worldwide, and Taiwan has one of the highest incidences (1). Based on the most updated annual statistics from the government, oral cancer is of the fourth death-causing cancers among Taiwanese males (2). Uniquely, betel quid chewing, in addition to cigarrete smoking and alcohol drinking, has been identified as an effective environmental factor to oral cancer risk in Taiwan (3). The Taiwan government has embarked in population screen searching for the oral cancer candidates for early cure and medication to lower its incidence, however, the death rate and incidence of oral cancer were still high. Therefore, novel predictors for oral cancer risk are still needed.There are five major DNA repair systems, consisting of more than 130 genes, and teaming up to maintain the stability and integrity of the human genome. Among them, the nucleotide excision repair (NER) system is in charge of removing DNA crosslinks, bulky adducts, alkylating DNA adducts, oxidative DNA adducts and thymidine dimers (4-6). In NER machinery, four major steps (adduct recognition, lesion DNA incision, gapped DNA fulfilling and ligation) and several core players, including xeroderma pigmentosum complementation group C (XPC)-RAD23B, play critical roles as key enzymes (4, 5) Theoretically, subtle genetic 441 This article is freely accessible online.

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Interaction of Interleukin-16 Genotypes With Betel Quid Chewing Behavior on Oral Cancer in Taiwan

Cited by 11 publications

References 17 publications

Association of functional IL16 polymorphisms with cancer and cardiovascular disease: a meta-analysis

Association of functional IL16 polymorphisms with cancer and cardiovascular disease: a meta-analysis

The Contribution of PDCD6 Polymorphisms to Oral Cancer Risk

Interaction of DNA Repair Gene XPC With Smoking and Betel Quid Chewing Behaviors of Oral Cancer

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