Interaction of infectious bursal disease virus with the immune system of poultry

Rehman, Zaib Ur; Meng, C.; Umar, Sajid; Munir, Muhammad; Chen, Ding

doi:10.1017/s0043933918000065

Cited by 8 publications

(8 citation statements)

References 2 publications

(1 reference statement)

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“…Genetic resistance is the intrinsic property of the chicken host to resist immunosuppressive agents. Genetic selection for resistance to immunosuppressive diseases has shown promising results (Hoerr, 2010;Cazaban, 2015;Rehman et al, 2016).…”

Section: Introductionmentioning

confidence: 95%

RETRACTED ARTICLE: Immunosuppressive interactions of viral diseases in poultry

Umar

Munir

Ahsan

et al. 2017

World's Poultry Science Journal

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Poultry can be exposed to different kinds of immunosuppressive agents that impair health and welfare by destroying innate and acquired immunity leading to diminished genetic potential of poultry for efficient production. Immunosuppression is a condition characterised by humoral and cellular immune dysfunction that leads to increased susceptibility to secondary infections and vaccine failure. Immune dysfunction at the humoral level is largely due to change in soluble factors mediated by complement or chemokines for innate immunity or due to alterations in antibodies or cytokines for adaptive immunity. In contrast, immune dysfunctions at cellular levels include alterations in neutrophils, monocyte/macrophage, and natural killer cells for innate immunity or changes in B or T lymphocytes for adaptive immunity. In poultry, stressinduced immunosuppression is manifested by failure in vaccination, and increased morbidity and mortality of flocks. Immunosuppressive agents can have cytolytic effects on lymphocyte populations leading to atrophied and depleted lymphoid organs. Immunosuppression can be due to infectious agents or noninfectious agents or due to a combination of them. At present, several modern cellular and molecular approaches are being used to determine the status of the immune system during stress and disease. Comprehensive methodologies for the evaluation of immunosuppression by combined non-infectious and infectious aetiologies have not found general application. Currently, investigations are being developed in order to detect genetic expression of immunologic mediators and receptors by microarray technology. It is likely that this new technique will initiate the development of new strategies for the control and prevention of immunosuppression in poultry. A long term immunosuppression preventive approach involves genetic selection for resistance to immunosuppressive diseases.

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Section: Introductionmentioning

confidence: 95%

RETRACTED ARTICLE: Immunosuppressive interactions of viral diseases in poultry

Umar

Munir

Ahsan

et al. 2017

World's Poultry Science Journal

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“…A study conducted by Jahromi et al 14 reported the expression profile for several groups of activator and suppressor NK cell receptors on the surface of 28.4 + IEL-NK cells using a qPCR approach and demonstrated that very virulent IBDV (vvIBDV) suppressed the activator receptors at 1-day post infection (dpi), but an overexpression of the surface activator was observed at 3 dpi. As the actual regulation of IBDV on NK cells was uncertain 15 , it is important to evaluate the response of IEL-NK cells against the vvIBDV infection, particularly at 3 dpi, to elucidate the actual role and response of IEL-NK cells in the innate immune response of chickens against this virus, which may help to establish foundations for improved prevention, including a vaccination strategy against IBDV. In this study, the whole transcriptome profiling of chicken IEL-NK cells infected by vvIBDV at 3 dpi was performed to gain insight into how such cells respond to vvIBDV.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome analysis of chicken intraepithelial lymphocyte natural killer cells infected with very virulent infectious bursal disease virus

Boo

Tan

Alitheen

et al. 2020

Sci Rep

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The infectious bursal disease (IBD) is an acute immunosuppressive viral disease that significantly affects the economics of the poultry industry. The IBD virus (IBDV) was known to infect B lymphocytes and activate macrophage and T lymphocytes, but there are limited studies on the impact of IBDV infection on chicken intraepithelial lymphocyte natural killer (IEL-NK) cells. This study employed an mRNA sequencing approach to investigate the early regulation of gene expression patterns in chicken IEL-NK cells after infection with very virulent IBDV strain UPM0081. A total of 12,141 genes were expressed in uninfected chicken IEL-NK cells, and most of the genes with high expression were involved in the metabolic pathway, whereas most of the low expressed genes were involved in the cytokine-cytokine receptor pathway. A total of 1,266 genes were differentially expressed (DE) at 3 day-post-infection (dpi), and these DE genes were involved in inflammation, antiviral response and interferon stimulation. The innate immune response was activated as several genes involved in inflammation, antiviral response and recruitment of NK cells to the infected area were up-regulated. This is the first study to examine the whole transcriptome profile of chicken NK cells towards IBDV infection and provides better insight into the early immune response of chicken NK cells.

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“…Різниця у рівнях антитіл виявлених у зразках сироватки крові може свідчити про різний час ін-фікування птахів, оскільки рівень антитіл зростає поступово зі збільшенням концентрації вірусу у крові. Високий рівень антитіл може свідчити також про ураження високовірулентними штамами вірусу ІБХ [7].…”

Section: результати та обговоренняunclassified

Seroprevalence of Infectious Bursal Disease Virus in Private Poultry Breedings of Ukraine From 2014 to 2016

Пастиря¹,

Собко²,

Шайхет³

et al. 2017

Microbiology&Biotechnology

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Вірус інфекційної бурсальної хвороби (ІБХ) поширений у більшості країн, що спеціалізуються на промисловому вирощуванні домашньої птиці. Вірус ІБХ належить до родини Birnaviridae, роду Avibirnavirus. Геном віру-су представлений двома сегментами (А -3,2 тис. п.о. та В -2,8 тис. п.о.) дволанцюгової РНК. Він уражує курчат 2-7 тижневого віку та призводить до

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Interaction of infectious bursal disease virus with the immune system of poultry

Cited by 8 publications

References 2 publications

RETRACTED ARTICLE: Immunosuppressive interactions of viral diseases in poultry

RETRACTED ARTICLE: Immunosuppressive interactions of viral diseases in poultry

Transcriptome analysis of chicken intraepithelial lymphocyte natural killer cells infected with very virulent infectious bursal disease virus

Seroprevalence of Infectious Bursal Disease Virus in Private Poultry Breedings of Ukraine From 2014 to 2016

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