Interaction of Gold Nanoparticles With Human Hepatocytes Hepg2 Line Under Conditions of 2d- And 3d-Cultivation

Abstract

A previously undescribed phenomenon of the inability of cells to uptake gold nanoparticles (GNPs) was discovered when studying HepG2 cells under the conditions of 2D- and 3D- cultivation (monolayer and spheroids). The same cells readily internalized GNPs functionalized with polyethyleneimine.