Interaction of filling related sensation between anorectum and lower urinary tract and its impact on the sequence of their evacuation. A study in healthy volunteers

Wachter, Stefan De; Jong, Andy de; Dyck, Johan Van; Wyndaele, Jean Jacques

doi:10.1002/nau.20384

Cited by 32 publications

(26 citation statements)

References 21 publications

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“…A close relationship between bladder function and intestinal function has been demonstrated in various animal models [9, 10] and in clinical studies [11, 12]. A urodynamic study by De Wachter et al showed that rectal distention significantly influences the sensation of bladder filling [13], while Panayi et al detected detrusor overactivity when the rectum was distended and not when it was empty [12]. Crosstalk between bladder and bowel might occur via overlapping neural pathways, including the dorsal root ganglia and spinal cord, and via shared neurotransmitters [14].…”

Section: Introductionmentioning

confidence: 99%

Female Functional Constipation Is Associated with Overactive Bladder Symptoms and Urinary Incontinence

Maeda

Tomita

Nakazawa

et al. 2017

BioMed Research International

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This noninterventional cross-sectional study aims to assess the association between functional constipation (FC) and urinary symptoms in female patients with no treatment for urination and defecation. The Rome III criteria for evaluation of defecation, Overactive Bladder Symptom Score (OABSS) for evaluation of urinary symptoms, and clinical features were investigated in 145 female patients. Latent FC and moderate to severe overactive bladder (OAB) were defined on the basis of positivity for two or more of the Rome III criteria and an OABSS ≥ 6 with OABSS Q3 ≥ 2, respectively. In 60 latent FC patients, the OABSS was higher (5.0 versus 3.2, p = 0.001), and concurrent moderate to severe OAB symptoms and OAB with urinary incontinence were more frequent than those in 85 nonlatent FC patients (33.3 versus 10.6%, p = 0.001, and 31.7 versus 7.1%, p < 0.001). Multivariate analysis demonstrated that moderate to severe OAB symptoms were a significant associated factor of latent FC (odds ratio (OR) = 4.125, p = 0.005), while latent FC was the only associated factor of moderate to severe OAB and OAB with urinary incontinence (OR = 4.227, p = 0.005 and OR = 4.753, p = 0.004). In conclusion, moderate to severe OAB symptoms are correlated with FC. Moreover, FC is related to moderate to severe OAB symptoms and to OAB with urinary incontinence.

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Section: Introductionmentioning

confidence: 99%

Female Functional Constipation Is Associated with Overactive Bladder Symptoms and Urinary Incontinence

Maeda

Tomita

Nakazawa

et al. 2017

BioMed Research International

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“…In the peripheral nervous system, the same nerves innervate the bladder and the anal rectum. In the central nervous system (CNS), afferent nerve signals from these organs are processed in the same regions of the brain, and both bladder and bowel functions are controlled by the same supraspinal regions such as the anterior cingulate gyrus, the insular cortex and the prefrontal cortex region of the brain [20,21].…”

Section: Discussionmentioning

confidence: 99%

Slow transit constipation and lower urinary tract dysfunction

Machado

Monteiro

Peçanha

et al. 2015

Journal of Pediatric Urology

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“…In animal experiments, both in vivo and in vitro , bladder‐to‐rectum and rectum‐to‐bladder reflexes were examined in healthy rats and pathological animal models . Furthermore, previous clinical studies showed that constipation alters bladder sensation, and simultaneous management of constipation and LUTS are recommended . Taken together, these observations show that the conditions of the rectum and bladder influence each other, and management of rectal conditions is also important for LUTS/OAB patients in Western medicine …”

Section: Clinical Concept Of General Kampo Medicinementioning

confidence: 95%

Status of urological Kampo medicine: A narrative review and future vision

Minagawa

Ishizuka

2015

Int J of Urology

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Abbreviations & Acronyms DKT = Dai-Ken-Chu-Tou ESWL = extracorporeal shock wave lithotripsy HC = hypersensitivity to cold IPSS = International Prostate Symptom Score LUTS = lower urinary tract symptoms OAB = overactive bladder OABSS = overactive bladder symptom score Qave = average urinary flow rate Qmax = maximum urinary flow rate QOL = quality of life RCT = randomized controlled trials TRP = transient receptor potential Abstract: Clinical evidence for traditional Japanese Kampo medicine has been provided by modern scientific methodologies. Indeed, more than 150 Kampo formulations have been approved for use as prescription drugs by the Ministry of Health, Labor and Welfare of Japan, and are widely used in daily medical practice. More than 10 of these formulations can be used for urological problems, especially in cases of lower urinary tract dysfunction. However, there are few opportunities to introduce urological Kampo medicines for worldwide use, and the status of urological Kampo medicine has not been reviewed yet. Here, we present a narrative review to introduce the current status of urological Kampo medicine in Japan. First, we introduce the essence of general Kampo medicine, including its history and current status in Japan. We focused of Sou-Sei-Sou-Koku, "promotion and inhibition network among the Five Elements," which is the central dogma of Kampo medicine. To present Kampo medicine as scientific medicine, neural cross-talk among pelvic organs is presented in comparison with Sou-Sei-Sou-Koku. Second, we list representative urological Kampo formulations used for lower urinary tract symptoms. Furthermore, we also discuss their roles in the urological field, including their position in Japanese clinical guidelines. Third, we propose the multi-organ targeting strategy using Kampo formulations as a future vision. Dai-Ken-Chu-Tou (a common Kampo formulation for gastrointestinal problems and hypersensitivity to cold) is one candidate, and we present the results of a preliminary study using this Kampo medicine formulation.

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Interaction of filling related sensation between anorectum and lower urinary tract and its impact on the sequence of their evacuation. A study in healthy volunteers

Abstract: When the bladder is full, sensation of rectal filling is decreased. When healthy people visit the toilet to defecate, the initiation of micturition often precedes that of defecation, even if both organs are considered equally full.

Cited by 32 publications

References 21 publications

Female Functional Constipation Is Associated with Overactive Bladder Symptoms and Urinary Incontinence

Female Functional Constipation Is Associated with Overactive Bladder Symptoms and Urinary Incontinence

Slow transit constipation and lower urinary tract dysfunction

Status of urological Kampo medicine: A narrative review and future vision

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