Interaction of Fe3+meso-tetrakis (2,6-dichloro-3-sulfonatophenyl) porphyrin with cationic bilayers: magnetic switching of the porphyrin and magnetic induction at the interface

Mugnol, Katia Cristina Ugolini; Martins, Marccus V. A.; Nascimento, Edvaldo C.; Nascimento, Otaciro Rangel; Crespilho, Frank N.; Arantes, Jeverson T.; Nantes, Iseli L.

doi:10.1007/s00214-011-1055-0

Cited by 5 publications

(5 citation statements)

References 64 publications

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“…TMPyP is a hydrophilic porphyrin, and it is not expected to be found buried in the bilayer. Thus, these spectral changes can be assigned to an electrostatic interaction of the positively charged metal‐free TMPyP meso ligands with the negatively charged interface of PC/CL .…”

Section: Resultsmentioning

confidence: 98%

Photodamage in a Mitochondrial Membrane Model Modulated by the Topology of Cationic and Anionic Meso‐Tetrakis Porphyrin Free Bases

Kawai

Araújo-Chaves

Magrini

et al. 2014

Photochem & Photobiology

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The photodynamic effects of the cationic TMPyP (meso-tetrakis [N-methyl-4-pyridyl]porphyrin) and the anionic TPPS4 (meso-tetrakis[4-sulfonatophenyl]porphyrin) against PC/CL phosphatidylcholine/cardiolipin (85/15%) membranes were probed to address the influence of phorphyrin binding on lipid damage. Electronic absorption spectroscopy and zeta potential measurements demonstrated that only TMPyP binds to PC/CL large unilamellar vesicles (LUVs). The photodamage after irradiation with visible light was analyzed by dosages of lipid peroxides (LOOH) and thiobarbituric reactive substance and by a contrast phase image of the giant unilamellar vesicles (GUVs). Damage to LUVs and GUVs promoted by TMPyP and TPPS4 were qualitatively and quantitatively different. The cationic porphyrin promoted damage more extensive and faster. The increase in LOOH was higher in the presence of D2O, and was impaired by sodium azide and sorbic acid. The effect of D2O was higher for TPPS4 as the photosensitizer. The use of DCFH demonstrated that liposomes prevent the photobleaching of TMPyP. The results are consistent with a more stable TMPyP that generates long-lived singlet oxygen preferentially partitioned in the bilayer. Conversely, TPPS4 generates singlet oxygen in the bulk whose lifetime is increased in D2O. Therefore, the affinity of the porphyrin to the membrane modulates the rate, type and degree of lipid damage.

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Section: Resultsmentioning

confidence: 98%

Photodamage in a Mitochondrial Membrane Model Modulated by the Topology of Cationic and Anionic Meso‐Tetrakis Porphyrin Free Bases

Kawai

Araújo-Chaves

Magrini

et al. 2014

Photochem & Photobiology

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“…Theoretical studies of porphyrins have also gained relevance [4,[20][21][22][23]. Synthesis of porphyrins is principally motivated by improved use in photodynamic therapy, energy, and catalysis [24][25][26]. The catalytic and photochemical properties of porphyrins are dependent on the presence and type of the central metal ion with axial ligands, the peripheral decoration, and microenvironment of the ring [11,27].…”

Section: Porphyrins and Hemeproteinsmentioning

confidence: 99%

Technological Applications of Porphyrins and Related Compounds: Spintronics and Micro-/Nanomotors

Lopes¹,

Araújo-Chaves²,

Menezes³

et al. 2019

Solid State Physics [Working Title]

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The vital role played by porphyrins in cells and their use in therapeutic processes are well known. More recently, the technological applications of porphyrins have attracted the attention of researchers. Porphyrins have the property of half-metallic material, i.e., molecules that can host transition metals making feasible the production of spin-polarized electronic states at different channels. Therefore, porphyrins and hemeproteins are among the materials that have spin-filtering property to be applied in spintronics. Molecular spintronics is an emerging and highly relevant field due to their applications to the development of high-capacity informationstorage devices and quantum computers. The catalytic properties of porphyrins and related compounds such as the hemeproteins are also applicable in the fabrication of micro-/nanomotors (MNMs). In this chapter, we describe the advances and future perspectives in the technological applications of porphyrins and related compounds in spintronic devices and micro-/nanomotors.

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“…These characteristics experimentally observed are consistent with the results obtained by density functional theory (DFT). Therefore, DFT/time-dependent (TD)DFT calculation is a useful strategy for the molecular design of porphyrins with the more appropriate characteristics for application is dye-sensitizer solar cells (DSSCs) [125][126][127][128][129]. As an example, Santhanamoorthi et al [129] have presented the theoretical study of newly designed porphyrin dyes (1−5) for DSSC applications.…”

Section: Technological Applicationsmentioning

confidence: 99%

Free-Base and Metal Complexes of 5,10,15,20-Tetrakis(NMethyl Pyridinium L)Porphyrin: Catalytic and Therapeutic Properties

Chaves¹,

Santos²,

Miranda³

et al. 2017

Phthalocyanines and Some Current Applications

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Porphyrins are tetrapyrrole macrocycles that can coordinate transition metal ions such as iron, cobalt and magnesium and are able to perform a diversity of functions and applications. In biological systems, these molecules are associated with proteins involved in photosynthesis, cell respiration, cell death, antioxidant defence, among others. The stability and versatile applications of porphyrins inspired the synthesis of derivatives including 5,10,15,20-tetrakis(N-methyl pyridinium-4-yl)porphyrin (TMPyP) that is the object of the present chapter. In synthetic porphyrins such as TMPyP, the catalytic and photochemical properties can be achieved by the coordination with a diversity of central metal ions. In photodynamic therapy (PDT), TMPyP and other porphyrins act as photosensitizers. The photochemical properties of TMPyP and other porphyrins are also useful for the fabrication of solar cells. The catalytic properties require the presence of a central metal. The MnTMPyP have antioxidant activity that is influenced the capacity of membrane binding, substituents, and meso substituents. Manipulation of the interfacial confinement properties is one of the newest application areas of porphyrins. The association of porphyrins with different surfaces modulates the electronic and physicochemical properties of these molecules. All of these properties are the object of experimental and theoretical studies discussed in the present chapter.

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Interaction of Fe3+meso-tetrakis (2,6-dichloro-3-sulfonatophenyl) porphyrin with cationic bilayers: magnetic switching of the porphyrin and magnetic induction at the interface

Cited by 5 publications

References 64 publications

Photodamage in a Mitochondrial Membrane Model Modulated by the Topology of Cationic and Anionic Meso‐Tetrakis Porphyrin Free Bases

Photodamage in a Mitochondrial Membrane Model Modulated by the Topology of Cationic and Anionic Meso‐Tetrakis Porphyrin Free Bases

Technological Applications of Porphyrins and Related Compounds: Spintronics and Micro-/Nanomotors

Free-Base and Metal Complexes of 5,10,15,20-Tetrakis(NMethyl Pyridinium L)Porphyrin: Catalytic and Therapeutic Properties

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