Interaction of Exo1 genotypes and smoking habit in oral cancer in Taiwan

Tsai, Ming Hsui; Tseng, Hsien Chang; Liu, Chiu Shong; Chang, Chia‐Lin; Tsai, Chia Wen; Tsou, Yung An; Wang, Rou Fen; Lin, Cheng Chieh; Wang, Hwei Chung; Chiu, Chang Fang; Bau, Da Tian

doi:10.1016/j.oraloncology.2009.03.011

Cited by 39 publications

(42 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar conclusion was obtained in the study of Taiwanese population, when it was found that the A allele of this polymorphism has a significant association and increase risk of lung cancer (P=0.0097) [35]. Interestingly, in other Taiwanese studies, in 2009, Wang et al [17], Tsai et al [44] & Bau et al [45] reported that the A allele EXO1 K589E conferred a significantly increased risk of gastric, oral and breast …”

Section: Discussionsupporting

confidence: 76%

See 1 more Smart Citation

Single Nucleotide Polymorphism (K589E) of the EXO1 Gene: Association with Colorectal Cancer Susceptibility and Clinicopathological Features

Aghdaei¹

2014

GHOA

View full text Add to dashboard Cite

Background and aim: Exonuclease1 (EXO1) is a member of the RAD2 nuclease family which is involved in mismatch repair (MMR) system and contributes to the maintenance of genomic stability, modulation of DNA recombination and cell cycle arrest mediation. K589E (rs1047840) as a potentially functional polymorphism in EXO1 gene may alter cancer risk by influencing its repair activity. Method:We designed a case-control study consisting of 319 subjects with colorectal cancer (CRC) and 310 healthy controls to investigate the effect of K589E polymorphism on CRC susceptibility and clinicopathological features in an Iranian population. Genotype determination was performed by PCR-RFLP method. Results:We provided the first evidence that there is not any significant association between EXO1 K589E alleles and genotypes and risk of CRC, even after adjustment for sex, age and smoking status (OR=1.033; 95% CI 0.814-1.312). Also analysis of clinicopathological characteristics and genotype distribution did not show any significant correlation. Conclusion:Despite the well-known role of EXO1, our results revealed that EXO1 K589E polymorphism could not be a potential predisposing risk factor in genetic susceptibility to CRC, at least in the studied population. A large scale case-control study will need to be carried out to further validate this polymorphism as a noncontributor to the risk of CRC in Iranian population.

show abstract

Section: Discussionsupporting

confidence: 76%

“…Regarding the important role of EXO1 in MMR system, this gene has become a famous target gene and widely investigated for its association with several cancers such as oral, CRC, lung and breast [17,35,37,44,47]. In this regard, numerous studies have reported several SNPs of EXO1 as genetic risk factors of cancer.…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphism (K589E) of the EXO1 Gene: Association with Colorectal Cancer Susceptibility and Clinicopathological Features

Aghdaei¹

2014

GHOA

View full text Add to dashboard Cite

show abstract

“…The study selection process is shown in Figure 1. A total of 10 case-control studies including 4391 cases and 4339 controls were analyzed in this metaanalysis (Zienolddiny et al, 2006;Chang et al, 2008;Hsu et al, 2008;Jin et al, 2008;Wang et al, 2009;Bau et al, 2009;Tsai et al, 2009;Ibarrola-Villava et al, 2011;Luo et al, 2012;Bayram et al, 2012). The characteristics of Exonuclease 1 Glu589Lys Gene Polymorphism and Cancer Susceptibility: Evidence Based on a Meta-Analysis selected studies are summarized in Table 1.…”

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

The Exonuclease 1 Glu589Lys Gene Polymorphism and Cancer Susceptibility: Evidence Based on a Meta-analysis

Bayram

2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: Published studies on the association between the exonuclease 1 (EXO1) Glu589Lys polymorphism and cancer susceptibility have yielded conflicting results. Thus, a meta-analysis of published studies was performed to assess the possible association. Materials and Methods: All eligible case-control studies published up to January 2013 on the association between the EXO1 Glu589Lys polymorphism and cancer susceptibility were identified by searching PubMed, Web of Science, Science Direct and hand search. Either fixed-effect or random-effect models were used to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) using the Comprehensive Meta-Analysis software version 2.2. Results: A total of 4,391 cancer cases and 4,339 controls from 10 studies were included. Overall, no significant association between the EXO1 Glu589Lys polymorphism and cancer susceptibility was observed in either genetic model. However; in subgroup analyses by cancer type, a significant association between EXO1 Glu589Lys and lung cancer risk was found (Lys

show abstract

“…Reactions that occur in alkylation and transalkyation processes and that are based on different types of the zeolite catalyst were investigated by certain authors [10][11][12]. However, alkylation and transalkyation have different conversion processes schemes, and at the same time they have quite much in common.…”

Section: Model Developmentmentioning

confidence: 99%

Modeling of Benzene with Ethylene Alkylation

Khlebnikova

Dolganova

Ivashkina

et al. 2016

MATEC Web of Conferences

View full text Add to dashboard Cite

Abstract. The paper considers the benzene alkylation with ethylene model development with the use of zeolite catalyst. A list of reactions occurring in the alkylation reactor was made and the thermodynamic possibility of determination of these reactions by the change of Gibbs energy was defined. The paper presents the hydrocarbons transformation scheme, which includes the grouping of components on the basis of their reactivity and the degrees of compensation values of the corresponding reactions. Drawing on the obtained data the authors developed the kinetic model of the alkylation of benzene with ethylene.

show abstract

Interaction of Exo1 genotypes and smoking habit in oral cancer in Taiwan

Cited by 39 publications

References 35 publications

Single Nucleotide Polymorphism (K589E) of the EXO1 Gene: Association with Colorectal Cancer Susceptibility and Clinicopathological Features

Single Nucleotide Polymorphism (K589E) of the EXO1 Gene: Association with Colorectal Cancer Susceptibility and Clinicopathological Features

The Exonuclease 1 Glu589Lys Gene Polymorphism and Cancer Susceptibility: Evidence Based on a Meta-analysis

Modeling of Benzene with Ethylene Alkylation

Contact Info

Product

Resources

About