Interaction of Excitatory Amino Acid Agonists with Cortical Afterdischarges in Developing Rats

Mareš, Pavel; Haugvicová, Renata; Kubová, Hana

doi:10.1046/j.1528-1157.43.s.5.21.x

Cited by 7 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pretreatment with L-NAME, in a dose-dependent manner, increased seizure incidence and severity and shortened latency time to the first seizure following the injection with the subconvulsive dose of H (5.5 mmol/kg, i.p.). This H dose was subthreshold and subconvulsive, and it could be used for some additional manipulations like cortical cobalt lesion, constant-current stimulation (Kubova et al 1995;Walton et al 1996;Mareš et al 2002) or L-NAME, like in our experiment, to induce a series of generalized clonic-tonic homocysteine-seizures.…”

Section: Discussionmentioning

confidence: 94%

The Role of Nitric Oxide in Homocysteine Thiolactone-Induced Seizures in Adult Rats

et al. 2009

View full text Add to dashboard Cite

The role of NO in epileptogenesis has been studied in different experimental models, and the reported results have been highly contradictory. The current study aimed to determine the role of NO in mechanisms of D: ,L: -homocysteine-thiolactone (H) induced seizures by testing the action of L: -arginine (NO precursor) and L: -NAME (NOS inhibitor) on behavioral and electroencephalographic (EEG) manifestations of H-induced seizures. The same holds true with the brain Na(+)/K(+)- and Mg(2+)-ATPase activity in adult male Wistar rats. We showed that the pretreatment with L: -arginine (300, 600 and 800 mg/kg, i.p.) in a dose-dependent manner significantly decreased lethality, seizure incidence and a number of seizure episodes and prolonged latency time to the first seizure elicited by a convulsive dose of H (8 mmol/kg, i.p.). L: -Arginine (800 mg/kg) completely reversed the inhibitory effect of H on the Na(+)/K(+)-ATPase activity in the hippocampus, the cortex and the brain stem and decreased the H-induced spike-and- wave discharges (SWD) formation in EEG. On the other hand, pretreatment with L: -NAME (200, 500 and 700 mg/kg, i.p.) potentiated a subconvulsive dose of H (5.5 mmol/kg, i.p) by increasing incidence and severity determined by a descriptive-rating scale (0-4) and shortening the latency time to the first seizure. The L: -NAME reversed H-induced alterations in the Na(+)/K(+)-ATPase activity in the cortex and the brain stem but not in the hippocampus. At last, the potentiated SWD appearance in EEG and an increased number of lethal outcomes occurred. In the present work, the modulation of NO levels, with the NO precursor and NOS inhibitor, was shed more light on its mechanism of action and answered the question whether NO could be included in the list of anticonvulsant agents in the D: ,L: -homocysteine thiolactone experimental model of seizures in adult rats.

show abstract

Section: Discussionmentioning

confidence: 94%

The Role of Nitric Oxide in Homocysteine Thiolactone-Induced Seizures in Adult Rats

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Lots of investigators have supported the statement that the higher seizure frequency has a negative influence on the QOL. [457810121617222324] In the scientific literature, there is no agreement whether the clinical factors (seizure frequency most often cited) or the psychic factors (depression most often cited) are the main predictors of the QOL of people with epilepsy. Some investigators have accepted the seizure frequency as a very significant QOL predictor.…”

Section: Discussionmentioning

confidence: 99%

“…[2] A lot of scientists have confirmed the moderate to very significant role of the seizure frequency and severity (especially in cases with more than 1 seizure/month) over QOL in patients with epilepsy. [34567] Tracy et al . have found that the seizure control is associated with the overall score of QOL and some quality of life epilepsy inventory (QOLIE-31) subscales — “seizure worry” and “social function”.…”

Section: Introductionmentioning

confidence: 99%

Seizure frequency and severity: How really important are they for the quality of life of patients with refractory epilepsy

Viteva

2014

Ann Indian Acad Neurol

View full text Add to dashboard Cite

Introduction:The data in the scientific literature about the significance of seizure severity and frequency for the quality of life (QOL) of patients with refractory epilepsy (RE) are contradictory.Objective:Our objective was to assess the impact of the seizure severity and frequency on the QOL of Bulgarian patients with RE.Materials and Methods:A total of 70 patients with RE were studied by examining the medical documentation and seizure diaries. All study participants completed quality of life epilepsy inventory (QOLIE-89). Seizure severity of only 59 patients who had a seizure in the last month was assessed by the Liverpool seizure severity scale.Results:A limited negative impact of the seizure severity and frequency on some aspects of the physical health, epilepsy, all aspects of the social health and epilepsy and the overall QOL has been demonstrated. A weak to moderate reverse correlation between the specified factors and the respective QOLIE-89 subscales has been found.Conclusion:The clinical factors seizure severity and seizure frequency have a limited negative impact mostly on the social aspects of QOL. The study results support the multidisciplinary approach to persons with epilepsy.

show abstract

“…This dose was subthreshold (Kubova et al 1995) and subconvulsive, unable to induce motor seizure, and thus it could be used as a pretreatment for some additional manipulations. Walton et al (1996) and Mareš et al (2002) observed a series of generalized clonic-tonic homocysteine-induced (5.5 mmol/kg b.w.) seizures after previous manipulation with cortical cobalt lesion and constant-current stimulation.…”

Section: Discussionmentioning

confidence: 99%

Two Types of Seizures in Homocysteine Thiolactone-Treated Adult Rats, Behavioral and Electroencephalographic Study

et al. 2008

View full text Add to dashboard Cite

D,L-homocysteine thiolactone (H), a reactive homocysteine metabolite, contributes to total homocysteine pool. The aim of the present study was to determine the effects of H after acute application in increasing doses to rats. Adult Wistar rat were intraperitoneally administered saline or H in increasing doses (5.5, 8.0, or 11.0 mmol/kg). For electroencephalographic (EEG) recordings, three gold-plated screws were implanted into the skull and animals were supervised. We observed H-induced two types of seizures, the coexistence of convulsive and nonconvulsive epilepsy. Dose-related increase in the number and severity (0-4) of displaying convulsions was recorded. In H(5.5) group, the majority of seizure episodes were grade 1 (62.5 and 0% lethality), in H(8) 40% grade 2, and in H(11) grade 4 in 42.11% (100% lethal outcome). EEGs recordings in convulsive animals showed a high-voltage spike-wave and polyspikes complexes. The second, absence-like, nonconvulsive seizures were accompanied by the EEGs mostly with 6-8 Hz spikes-and-wave discharges (SWD). Latency time to the generalized clonic-tonic seizures overlapped with the time of the maximal median number and median duration of the SWD per 15 min during 90-min observing period. The results show that acute H administration significantly changes neurons, EEG tracings, and behavioral responses and suggests a possible model for studying petit mal epilepsy.

show abstract

Interaction of Excitatory Amino Acid Agonists with Cortical Afterdischarges in Developing Rats

Cited by 7 publications

References 29 publications

The Role of Nitric Oxide in Homocysteine Thiolactone-Induced Seizures in Adult Rats

The Role of Nitric Oxide in Homocysteine Thiolactone-Induced Seizures in Adult Rats

Seizure frequency and severity: How really important are they for the quality of life of patients with refractory epilepsy

Two Types of Seizures in Homocysteine Thiolactone-Treated Adult Rats, Behavioral and Electroencephalographic Study

Contact Info

Product

Resources

About