Interaction of dopamine and haloperidol with O2 and CO2 chemoreception in carotid body

Lahiri, S.; Nishino, Takashi; Mokashi, A.; Mulligan, E.

doi:10.1152/jappl.1980.49.1.45

Cited by 64 publications

(42 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In adult and newborn cats, dopamine may elicit excitation as well as inhibition of the chemosensory discharge, and it is thought that both excitatory and inhibitory dopamine receptors are present in the carotid body [10. 20, 21], Haloperidol, a specific D2 dopamine receptor blocker produces prolonged stimula tion on cat carotid chemosensory discharge [12], The present study shows similar obser vations in the kitten but haloperidol did not interfere with the stimulant effect of doxa pram. Whatever mechanisms of chemotrans-duction dopamine is involved in, doxapram appears to act independent of them.…”

Section: Discussionsupporting

confidence: 71%

“…8]. Further more, at this dose, doxapram has been shown to stimu late breathing in newborn lambs without significantly affecting arterial blood pressure [11], Group 2 received doxapram after a slow injection o f haloperidol ( 1 mg/kg of the commercial intravenous Haldol® solu tion), a saturation dose that has been shown to block dopamine D2 receptors for at least 2 h in adult cats [12], In the kitten preparation, attempts to further increase the dose o f haloperidol induced a precipitous fall in blood pressure. Each solution was prepared by diluting the drug in normal saline in order to achieve a total volume o f fluid o f 0.2 ml.…”

Section: Drug Administrationmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Doxapram on Carotid Chemoreceptor Activity in Newborn Kittens

et al. 1993

Self Cite

View full text Add to dashboard Cite

Doxapram is a respiratory stimulant which acts on peripheral chemoreceptors and central respiratory neurons in a dose-dependent fashion in the adult cat. In the newborn, the mechanisms of action of doxapram are still unclear. To evaluate the effects of doxapram on the carotid chemosensory discharge and its relationship with dopaminergic mechanisms in the carotid body, two groups of kittens less than 13 days old, anesthetized, artificially ventilated and paralyzed, were prepared for the recording of a single or a few chemosensory afferents of the carotid sinus nerve. The chemosensory activity was recorded under five conditions of inspired gas mixtures (21 and 8% O₂ in N₂, 100% O₂, 5 and 10% CO₂ in O₂). Group 1 (n = 9) received only doxapram and group 2 (n = 8) was pretreated with haloperidol (1 mg/kg), a dopamine D2-receptor blocker, before receiving doxapram. Doxapram significantly stimulated the discharge rate of the carotid chemoafferents under all conditions of inspired gas. The chemosensory discharge was increased by haloperidol, and was raised further after doxapram by an amount similar to group 1. For instance, in normoxia, the activity increased from 2.9 ± 0.4 to 7.5 ± 0.9 impulse/s (mean ± SEM, p < 0.01) in group 1 and from 3.8 ± 0.6 to 9.1 ± 1.0 impulse/s (p < 0.01) in group 2. These results indicate that the mechanisms of response of carotid chemoreceptor to doxapram are developed in the newborn kitten and doxapram acts independent of the dopaminergic mechanisms in the carotid body.

show abstract

Section: Discussionsupporting

confidence: 71%

Section: Drug Administrationmentioning

confidence: 99%

Effects of Doxapram on Carotid Chemoreceptor Activity in Newborn Kittens

et al. 1993

Self Cite

View full text Add to dashboard Cite

show abstract

“…(McQueen, 1977;Docherty & McQueen, 1978, 1979Liados & Zapata, 1978a, b). There have been relatively few investigations of chemoreceptor responses to these putative transmitters over a range of Pa°2 (Lahiri, Nishino, Mokashi & Mulligan, 1980;Lahiri, Pokorski & Davies, 1981;Folgering et al 1982). In addition, there are no reports on the effects of ACh infusions upon chemoreceptor afferent activity, nor have the effects of intracarotid infusions of ACh and DA been compared between the rabbit and cat.…”

Section: Prolonged Hypoxiamentioning

confidence: 99%

Interactions between hypoxia, acetylcholine and dopamine in the carotid body of rabbit and cat.

Ponte¹,

Sadler²

1989

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Acetylcholine (ACh) and dopamine (DA) were either infused into the carotid artery or applied directly to the surface of the carotid body of twenty-six rabbits and fifteen cats. Afferent discharge of single chemoreceptor units was recorded at a range of Pa O2 (arterial 02 pressure) values during drug administration.2. There were no observable systemic effects of either drug when applied to the surface of the carotid body.3. Acetylcholine tended to depress afferent discharge when applied to the surface of the rabbit carotid body or when infused into the carotid sinus. In the cat, intracarotid and surface application of ACh had mild and inconsistent effects. DA consistently depressed discharge in both species independent of the route of administration. Antagonists of ACh and DA failed to abolish the chemoreceptor response to hypoxia.4. The changes in afferent discharge elicited by all drugs were small compared with the range of discharge rates attained with physiological stimuli. The effects of ACh and DA were more marked in hyperoxia than in hypoxia for both routes of administration, disappearing at PakO values close to 20 Torr (7 5 Torr = 1 kPa). 5. A role for DA in the maintenance of the hypoxic response was investigated in six rabbits. After 15 min of hypoxia (Pa°2 = 21P8±+ 1 Torr; mean+s.E.M.) the discharge of single chemoreceptor fibres adapted moderately (to 79-3 + 5-2 % of maximum discharge). Following administration of domperidone or haloperidol (1(0-5-3 mg kg-', i.v.) the same fibres responded with equal magnitude to the onset of the hypoxic stimulus but showed a significantly larger adaptation (to 48-5 + 4.4 %).6. It is concluded that endogenous ACh and DA are unlikely to mediate the transduction process of the carotid body, but DA may play a role in preventing adaptation to a prolonged hypoxic stimulus.

show abstract

“…Exogenous administration of dopamine causes a complex response of inhibition and excitation in cat, dog and rabbit carotid body [1]. Similarly, catecholamine antagonists, administered in vivo, generally cause an increase (not the expected decrease) in hypoxia sensitivity [2,3]. This variability in response leads to two conclusions, either catecholamines are not primary excitatory transmitters or the impor tant excitatory site is not accessible to drugs.…”

Section: Introductionmentioning

confidence: 99%

Does Catecholamine Secretion Mediate the Hypoxia-lnduced Increase in Nerve Activity?

Donnelly¹

1995

Neurosignals

View full text Add to dashboard Cite

Catecholamine secretion from carotid body glomus cells is hypothesized to cause the hypoxia-induced increase in nerve activity. To test aspects of this hypothesis, tissue catecholamine and single-fiber nerve activity was measured from rat carotid bodies in vitro. Hypoxia (1-min duration, 0 Torr at nadir) caused a rapid increase in catecholamine release and nerve activity, consistent with the hypothesis, but repetitive hypoxias interspersed with short rest periods resulted in a much greater decline in catecholamine release than nerve activity. Furthermore, pretreatment with reserpine (24 h) nearly abolished catecholamine release, but nerve response was not different than untreated controls. These results suggest that catecholamine secretion is not causal to the increase in nerve activity of rat carotid body.

show abstract

Interaction of dopamine and haloperidol with O2 and CO2 chemoreception in carotid body

Cited by 64 publications

References 0 publications

Effects of Doxapram on Carotid Chemoreceptor Activity in Newborn Kittens

Effects of Doxapram on Carotid Chemoreceptor Activity in Newborn Kittens

Interactions between hypoxia, acetylcholine and dopamine in the carotid body of rabbit and cat.

Does Catecholamine Secretion Mediate the Hypoxia-lnduced Increase in Nerve Activity?

Contact Info

Product

Resources

About