Interaction of daunomycin antibiotic with human serum albumin: Investigation by resonant mirror biosensor technique, fluorescence spectroscopy and molecular modeling methods

Tang, Kai; Qin, Yimin; Lin, Aijun; Hu, Xiaofeng; Zou, Guolin

doi:10.1016/j.jpba.2005.03.045

Cited by 34 publications

(12 citation statements)

References 34 publications

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“…The fluorescence quenching phenomenon of organic molecules using external quenchers in a liquid phase has been widely investigated by various authors to understand the nature of bimolecular reactions taking place both under steady-state and transient conditions [37][38][39][40]. Such studies are of utmost importance in physical, chemical, biological and medical sciences.…”

Section: Quenching Mechanism Of Htf By Tamoxifenmentioning

confidence: 99%

Investigation on the interaction between tamoxifen and human holo-transferrin: Determination of the binding mechanism by fluorescence quenching, resonance light scattering and circular dichroism methods

Sarzehi¹,

Chamani²

2010

International Journal of Biological Macromolecules

157

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Section: Quenching Mechanism Of Htf By Tamoxifenmentioning

confidence: 99%

Investigation on the interaction between tamoxifen and human holo-transferrin: Determination of the binding mechanism by fluorescence quenching, resonance light scattering and circular dichroism methods

Sarzehi¹,

Chamani²

2010

International Journal of Biological Macromolecules

157

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“…It has an important role in maintaining the colloidal osmotic pressure in blood. It also transports and distributes exogenous and endogenous substances, such as nutrients, hormones, fatty acids and many diverse drugs [8,9]. HSA is a globular protein consisting of 585 amino acid residues and considered to have three specific binding sites (labeled as I-III) [10].…”

Section: Introductionmentioning

confidence: 99%

Interaction of the docetaxel with human serum albumin using optical spectroscopy methods

Cheng

Liu

Zhang

et al. 2009

Journal of Luminescence

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“…For static quenching, the number of binding sites can be determined according to the double-logarithmic equation (Equation (3)) [37][38][39]:…”

Section: Binding Sites and Identification Of Binding Sites On Hsamentioning

confidence: 99%

Comparative Interactions of Dihydroquinazolin Derivatives with Human Serum Albumin Observed via Multiple Spectroscopy

et al. 2017

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Abstract:The interactions of dihydroquinazolines with human serum albumin (HSA) were studied in pH 7.4 aqueous solution via fluorescence, circular dichroism (CD) and Fourier transform infrared (FTIR) spectroscopic techniques. In this work, 6-chloro-1-(3,3-dimethyl-butanoyl)-2-(un)substitutedphenyl-2,3-dihydroquinazolin-4(1H)-one (PDQL) derivatives were designed and synthesized to study the impact of five similar substituents (methyl, methoxy, cyano, trifluoromethyl and isopropyl) on the interactions between PDQL and HSA using a comparative methodology. The results revealed that PDQL quenched the intrinsic fluorescence of HSA through a static quenching process. Displacement experiments with site-specific markers revealed that PDQL binds to HSA at site II (subdomain IIIA) and that there may be only one binding site for PDQL on HSA. The thermodynamic parameters indicated that hydrophobic interactions mainly drove the interactions between PDQL and HSA. The substitution using five similar groups in the benzene ring could increase the interactions between PDQL and HSA to some extent through the van der Waals force or hydrogen bond effects in the proper temperature range. Isopropyl substitution could particularly enhance the binding affinity, as observed via comparative studies.

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Interaction of daunomycin antibiotic with human serum albumin: Investigation by resonant mirror biosensor technique, fluorescence spectroscopy and molecular modeling methods

Cited by 34 publications

References 34 publications

Investigation on the interaction between tamoxifen and human holo-transferrin: Determination of the binding mechanism by fluorescence quenching, resonance light scattering and circular dichroism methods

Investigation on the interaction between tamoxifen and human holo-transferrin: Determination of the binding mechanism by fluorescence quenching, resonance light scattering and circular dichroism methods

Interaction of the docetaxel with human serum albumin using optical spectroscopy methods

Comparative Interactions of Dihydroquinazolin Derivatives with Human Serum Albumin Observed via Multiple Spectroscopy

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