Interaction of ciprofloxacin with the activated sludge of the sewage treatment plant

Wang, Kan; Gao, Dingshan; Xu, Jiexin; Cai, Ling; Cheng, Junrui; Yu, Zhuoping; Hu, Zenghui; Yu, Jie

doi:10.1007/s11356-018-3413-0

Cited by 12 publications

(4 citation statements)

References 35 publications

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“…In aqueous solution, depending on the pH, CIP is an amphoteric molecule that could be charged (positive charge due to the protonated amine groups at pH < 6 and negative charge due to the deprotonated carboxyl group at pH > 9) and non-charged/zwitterionic (at neutral pH) [ 23 ]. Consequently, CIP is extensively soluble at acidic/basic pH and sparingly soluble at neutral pH [ 24 ]. Numerous materials have been evaluated regarding the CIP adsorption/release profiles and their mechanisms/kinetics, namely natural bio-sorbents, magnetic materials, clays, hydrogels, and activated carbons [ 25 – 28 ].…”

Section: Introductionmentioning

confidence: 99%

Formulations of poly(vinyl alcohol) functionalized silk fibroin nanoparticles for the oral delivery of zwitterionic ciprofloxacin

Thi Phuong Thao,

Nguyen,

et al. 2024

PLoS ONE

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Fibroin nanoparticles (FNP) have been employed in numerous biomedical applications. However, limited research has focused on the oral delivery of FNP and in-depth molecular interactions between the encapsulated drug and FNP. Therefore, this work developed the FNP, functionalized with poly(vinyl alcohol) (PVA), to orally deliver the zwitterionic ciprofloxacin, focused on the molecular interactions. The particles were formulated using both desolvation (the drug precipitated during the particles formulation) and adsorption (the drug adsorbed on the particles surfaces) methods. The optimal formula possessed a size of ~630 nm with narrow size distribution (measured by DLS method), spherical shape (determined by SEM), and moderate drug loading (confirmed by FT-IR, XRD, and DSC techniques) of ~50% for the desolvation method and ~43% for the adsorption method. More than 80% of the drug molecules resided on the particle surfaces, mainly via electrostatic forces with fibroin. The drug was physically adsorbed onto FNP, which followed Langmuir model and pseudo second-order kinetics. In the in-vitro simulated gastric condition at pH 1.2, the ciprofloxacin bound strongly with FNP via electrostatic forces, thus hindering the drug release (< 40%). Contrastingly, in the simulated intestinal condition at pH 6.8, the particles could control the drug release rates dependent on the PVA amount, with up to ~100% drug release. Lastly, the particles possessed adequate antibacterial activities on Bacillus subtilis, Escherichia coli, and Salmonella enterica, with MIC of 128, 8, and 32 μg/mL, respectively. In summary, the FNP and PVA functionalized FNP could be a potential oral delivery system for zwitterionic drugs.

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Section: Introductionmentioning

confidence: 99%

Formulations of poly(vinyl alcohol) functionalized silk fibroin nanoparticles for the oral delivery of zwitterionic ciprofloxacin

Thi Phuong Thao,

Nguyen,

et al. 2024

PLoS ONE

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“…The carbohydrates‐based materials are low‐cost, efficient, and easy to obtain from natural sources. Besides, carbohydrates are the second biomolecules group adsorbing CIP in sewage sludge [6] and microalgae [7] . In both cases, the carbohydrates allow the complexation and further release of CIP.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Ciprofloxacin with Arabinose, Glucosamine, Glucuronic Acid and Rhamnose: Insights from Genetic Algorithm and Quantum Chemistry

et al. 2022

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A theoretical study of the ciprofloxacin interactions with glucuronic acid, arabinose, glucosamine, and rhamnose is presented. The most stable complexes were obtained through genetic algorithms starting from the neutral and zwitterion species of ciprofloxacin. The energy at the semiempirical level PM7 of the optimal structures of the complexes was the genetic algorithm‘s fitness function. The resulting complexes’ geometry was optimized at M062X−D3/6‐311++G** level of theory, and non‐covalent interactions were assessed through the reduced density gradient and quantum theory of atoms in molecules. The results show that the zwitterion species of ciprofloxacin favorably complex carbohydrates and can induce proton exchange between them. The molecular complexes from proton exchange are the most stable, followed by the complexes formed by the contact of the zwitterion species and the carbohydrate. The complexes formed by both neutral species were the least stable. The medium strength and strong (assisted by charge) hydrogen bonds, the XH⋅⋅⋅π and lone‐pair⋅⋅π interactions, were mainly present in the complexes. Proton exchange processes strengthen the interactions mentioned above.

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“…At the C/N = 1.5 and 3.5, the final effluent of CIP concentrations was 106.36 µg•L −1 and 116.99 µg•L −1 , respectively, as shown inFigure 5[50,53,54]. It was shown that denitrification inhibited CIP, and that development was more obvious during the prolonged microbial cultivation period[6,55,56].Sustainability 2020, 12, x FOR PEER REVIEW 13 of 21…”

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confidence: 96%

Effect of the C/N Ratio on Biodegradation of Ciprofloxacin and Denitrification from Low C/N Wastewater as Assessed by a Novel 3D-BER System

et al. 2020

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Emerging pollutants in the form of pharmaceuticals have drawn international attention during the past few decades. Ciprofloxacin (CIP) is a common drug widely found in effluents from hospitals, industrial and different wastewater treatment plants, as well as rivers. In this work, the lab-scale 3D-BER system was established, and more than 90% of the antibiotic CIP was removed from Low C/N wastewater. The best results were obtained with the current intensity being taken into account, and a different C/N ratio significantly improved the removal of CIP and nitrates when the ideal conditions were C/N = 1.5–3.5, pH = 7.0–7.5 and I = 60 mA. The highest removal efficiency occurred when CIP = 94.2%, NO3−-N = 95.5% and total nitrogen (TN) = 84.3%, respectively. In this novel system, the autotrophic-heterotrophic denitrifying bacteria played a vital role in the removal of CIP and an enhanced denitrification process. Thus, autotrophic denitrifying bacteria uses CO2 and H2 as carbon sources to reduce nitrates to N2. This system has the assortment and prosperous community revealed at the current intensity of 60 mA, and the analysis of bacterial community structure in effluent samples fluctuates under different conditions of C/N ratios. Based on the results of LC-MS/MS analysis, the intermediate products were proposed after efficient biodegradation of CIP. The microbial community on biodegrading was mostly found at phylum, and the class level was dominantly responsible for the NO3−-N and biodegradation of CIP. This work can provide some new insights towards the biodegradation of CIP and the efficient removal of nitrates from low C/N wastewater treatment through the novel 3D-BER system.

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Interaction of ciprofloxacin with the activated sludge of the sewage treatment plant

Cited by 12 publications

References 35 publications

Formulations of poly(vinyl alcohol) functionalized silk fibroin nanoparticles for the oral delivery of zwitterionic ciprofloxacin

Formulations of poly(vinyl alcohol) functionalized silk fibroin nanoparticles for the oral delivery of zwitterionic ciprofloxacin

Interaction of Ciprofloxacin with Arabinose, Glucosamine, Glucuronic Acid and Rhamnose: Insights from Genetic Algorithm and Quantum Chemistry

Effect of the C/N Ratio on Biodegradation of Ciprofloxacin and Denitrification from Low C/N Wastewater as Assessed by a Novel 3D-BER System

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