Interaction of chitosan with Cefotaxime

Mudarisova, R. Kh.; Kulish, E. I.; Zinatullin, R. M.; Tamindarova, N. E.; Колесов, С. В.; Khunafin, S. N.; Monakova, Yu. B.

doi:10.1134/s1070427206070354

Cited by 7 publications

(3 citation statements)

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“…The presence of non‐stoichiometric complexes indicates that some of CH amino groups were not involved in complexation. Similar results were reported in Mudarisova et al [ 23 ] for CH–CFT complexation in aqueous solutions of acetic acid. A reduction in pH of the medium with the addition of the acid led to a considerable decrease in the content of CFT in the reaction product.…”

Section: Resultssupporting

confidence: 91%

“…[ 19–22 ] A capacity of this polysaccharide to bind low‐molecular medicinal compounds has not been characterized in detail. [ 23–25 ]…”

Section: Introductionmentioning

confidence: 99%

“…[19][20][21][22] A capacity of this polysaccharide to bind lowmolecular medicinal compounds has not been characterized in detail. [23][24][25] In this work, sodium salt of cefotaxime (CFT) was used as a model drug. CFT is a β-lactam antibiotic of the cefalosporine group.…”

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confidence: 99%

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Alginate/chitosan hydrogels as perspective transport systems for cefotaxime

et al. 2023

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This work reports synthesis of pH‐responsive alginate/chitosan hydrogel spheres with the average diameter of 2.0 ± 0.05 mm, which contain cefotaxime that is an antibiotic of the cefalosporine group. The spheres provided the cefotaxime encapsulation efficiency of 95 ± 1%. An in vitro release of cefotaxime from the spheres in the media that simulate human biological fluids in peroral delivery conditions was found to be a pH‐dependent process. The analysis of cefotaxime release kinetics by the Korsmeyer–Peppas model revealed a non‐Fickian mechanism of its diffusion, which may be related to intermolecular interactions occurring between the antibiotic and chitosan. Conductometry, UV spectroscopy, and IR spectroscopy were used to study complexation of chitosan with cefotaxime in aqueous media with varied pH, characterize the composition of the complexes, and calculate their stability constants. The composition of the cefotaxime–chitosan complexes was found to correspond to the 1.0:4.0 and 1.0:2.0 molar ratios of the components at pH 2.0 and 5.6, respectively. Quantum chemical modeling was used to evaluate energy characteristics of chitosan–cefotaxime complexation considering the influence of a solvent.

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Section: Resultssupporting

confidence: 91%

“…[ 19–22 ] A capacity of this polysaccharide to bind low‐molecular medicinal compounds has not been characterized in detail. [ 23–25 ]…”

Section: Introductionmentioning

confidence: 99%