Interaction of cells and nanofiber scaffolds in tissue engineering

Abstract

Nanofibers and nanomaterials are potentially recent additions to materials in relation to tissue engineering (TE). TE is the regeneration of biological tissues through the use of cells, with the aid of supporting structures and biomolecules. Mimicking architecture of extracellular matrix is one of the challenges for TE. Biodegradable biopolymer nanofibers with controlled surface and internal molecular structures can be electrospun into mats with specific fiber arrangement and structural integrity for drug delivery and TE applications. The polymeric materials are widely accepted because of their ease of processability and amenability to provide a large variety of cost-effective materials, which help to enhance the comfort and quality of life in modern biomedical and industrial society. Today, nanotechnology and nanoscience approaches to scaffold design and functionalization are beginning to expand the market for drug delivery and TE is forming the basis for highly profitable niche within the industry. This review describes recent advances for fabrication of nanofiber scaffolds and interaction of cells in TE.

A nanofibrous PHBV tube with Schwann cell as artificial nerve graft contributing to Rat sciatic nerve regeneration across a 30-mm defect bridge

“…Nanofi brous polymeric conduits have improved the performance of biomaterials. Electro spinning is one of the most important methods for the fabrication of nanofi brous scaffolds (Hromadka et al, 2008;Venugopal et al, 2008). In this study, nanofi brous PHBV conduit was fabricated by electro-spinning method.…”

Nano-fiber scaffold electrodes based on PEDOT for cell stimulation

“…In order to mimic the complex in vivo 3D environment several artificial surfaces and scaffolds have been developed, including micro-and nanostructured surfaces [1][2][3][4][5], biomolecular coatings [6], gels [7], and nano-fibrous scaffolds [8][9][10]. Planar electronically active cell seeding surfaces based on conjugated polymers have been used to control the cell adhesion and proliferation of various cell systems [11][12][13].…”

Sum frequency generation and solid-state NMR study of the structure, orientation, and dynamics of polystyrene-adsorbed peptides

“…Development of biocompatible surfaces is also a major focus of the materials and tissue engineering communities (1)(2)(3)(4), particularly for using peptide or protein coatings in recreating a natural extracellular matrix to direct wound repair or tissue development and homeostasis (5)(6)(7). Understanding the structural and dynamic impact of protein adsorption at the molecular level is therefore crucial for the design of future bioactive surface coatings and interfaces.…”