Interaction of cell culture with composition effects on the mechanical properties of polycaprolactone-hydroxyapatite scaffolds fabricated via selective laser sintering (SLS)

Eosoly, Szilvia; Vrana, Nihal Engin; Lohfeld, Stefan; Hindié, Mathilde; Looney, L.

doi:10.1016/j.msec.2012.06.011

Cited by 70 publications

(61 citation statements)

References 38 publications

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“…However, for the porous microsphere-based HA/PCL scaffolds in this study, the compressive modulus and compressive strength tend to decrease as the incorporation of HA, since the surface HA impeded the sintering degree, even using higher energy density. These results are in accordance with previous finding, and it was suggested that the effect of HA addition on the mechanical properties was dependent on how strong the sintering was, as HA impaired mechanical properties when sintering was weak [37].…”

Section: Discussionsupporting

confidence: 93%

“…Both compressive modulus and compressive strength are at the same level with other reported works on porous HA/PCL scaffolds fabricated by SLS [9,37] [38]. The effect of HA addition on the compressive properties has been studied.…”

Section: Discussionsupporting

confidence: 67%

“…Eosoly et al demonstrated the 15 wt. % HA-PCL scaffolds promoted the proliferation and ALP activity during the initial 7-days period [37]. Xia et al [38] and Abdal-hay et al [42] reported significant cell proliferation elicited by 10% HA in scaffolds fabricated by SLS and air jet spinning, respectively.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Microsphere-based selective laser sintering for building macroporous bone scaffolds with controlled microstructure and excellent biocompatibility

Liu

Jiaqi

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 67%

See 1 more Smart Citation

Microsphere-based selective laser sintering for building macroporous bone scaffolds with controlled microstructure and excellent biocompatibility

Liu

Jiaqi

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…Meanwhile, Laurea [17] emphasized in his doctor dissertation that the porosity of hybrid composite scaffold was lower than 60 %, which was not desirable for cell growth. Szilvia et al [18] confirmed that as-SLS Poly-ε-Caprolactone (PCL)/15 wt% HA composite showed better metabolic activity than as-SLS pure PCL. However, the main drawbacks of PCL are its long degradation and resorption period because of hydrophobicity and high crystallinity [18,19].…”

Section: Introductionmentioning

confidence: 98%

Selective laser sintering of aliphatic-polycarbonate/hydroxyapatite composite scaffolds for medical applications

Song

Wei

Song

et al. 2015

Int J Adv Manuf Technol

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This study investigated the selective laser sintering (SLS) of aliphatic-polycarbonate/hydroxyapatite (a-PC/HA) composite scaffolds for medical applications. The effects of material ratios and SLS processing parameters on the porosity, microstructures and mechanical properties of the samples were observed. The optimized proportion in the a-PC/HA composite was found to be 10 wt% HA. The processing parameters were optimized as: 10 W of laser power, 2000 mm/s of scan speed, 0.15 mm of scan spacing, and 0.17 mm of layer thickness. With the optimized process, the scaffold porosity and compressive module were increased to 77.36 % and 26 MPa, respectively. The pores were interconnected, indicating the existence of more space for cell ingrowth and the improvement in the load capability of bone scaffold. The nanoscale HA particles were fully or partially embedded in a-PC matrix and did not decompose during the SLS processing. Crystalline behavior, bioactive activity, and osteoconduction, beneficial for bone ingrowth, scarcely changed before and after sintering. The successful manufacturing of complex scaffold with smooth surface demonstrated that surface roughness could be controlled by optimizing HA content and adjusting the processing parameters. The a-PC/HA composite powder could be used to manufacture complex porous parts by using the SLS process for medical applications.

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“…Numerous studies have been done to evaluate the potential of SLS in producing composite scaffolds containing polymer and ceramic [19, 71, 72]. The main issue for ceramic/polymer composites is the agglomeration of ceramic powders into the polymer matrix.…”

Section: Laser Sintering Technologymentioning

confidence: 99%

A review on powder-based additive manufacturing for tissue engineering: selective laser sintering and inkjet 3D printing

Shirazi

Gharehkhani

Mehrali

et al. 2015

Science and Technology of Advanced Materials

573

324

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Since most starting materials for tissue engineering are in powder form, using powder-based additive manufacturing methods is attractive and practical. The principal point of employing additive manufacturing (AM) systems is to fabricate parts with arbitrary geometrical complexity with relatively minimal tooling cost and time. Selective laser sintering (SLS) and inkjet 3D printing (3DP) are two powerful and versatile AM techniques which are applicable to powder-based material systems. Hence, the latest state of knowledge available on the use of AM powder-based techniques in tissue engineering and their effect on mechanical and biological properties of fabricated tissues and scaffolds must be updated. Determining the effective setup of parameters, developing improved biocompatible/bioactive materials, and improving the mechanical/biological properties of laser sintered and 3D printed tissues are the three main concerns which have been investigated in this article.

show abstract

Interaction of cell culture with composition effects on the mechanical properties of polycaprolactone-hydroxyapatite scaffolds fabricated via selective laser sintering (SLS)

Cited by 70 publications

References 38 publications

Microsphere-based selective laser sintering for building macroporous bone scaffolds with controlled microstructure and excellent biocompatibility

Microsphere-based selective laser sintering for building macroporous bone scaffolds with controlled microstructure and excellent biocompatibility

Selective laser sintering of aliphatic-polycarbonate/hydroxyapatite composite scaffolds for medical applications

A review on powder-based additive manufacturing for tissue engineering: selective laser sintering and inkjet 3D printing

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