Interaction of calcium and somatostatin in the control of prolactin and somatotropin release from a primary culture of rat adenohypophyseal cells

Phorbol Ester-Induced LH Release in Pituitary Gonadotrophs: Effects of Antagonists of Calmodulin and GnRH.

“…THE ACTIONS of many peptide hormones are mediated by calcium [1][2][3][4][5][6][7][8] and the mechanism of action of GnRH on LH release also appears to involve calcium-dependent processes rather than cyclic nucleotides [9,10] . Recent studies have shown that the GnRH-induced response of cytosolic Ca2+ concentration ([Ca2+]i) is closely correlated with the secretory response [11] and that calcium influx through selective calcium channels is important in regulating the GnRH-induced…”

Lack of Effect of Histidyl-Proline Diketopiperazine on Basal Level and TRH-Induced Response of Cytosolic Calcium Concentration in Rat Lactotrophs.

“…The action of TRH is mediated by calcium [14] and intracellular calcium-dependent processes play an important role in the mechanism of PRL release [15][16][17]. The TRH-stimulated increase in the cytosolic Ca2+ concentration ([Ca2+]i) is a major regulator of the secretory response [18].…”