Interaction of Caffeine With Regadenoson-Induced Hyperemic Myocardial Blood Flow as Measured by Positron Emission Tomography

Gaemperli, Oliver; Schepis, Tiziano; Koepfli, Pascal; Siegrist, Patrick T.; Fleischman, Samuel; Nguyen, Patricia K.; Olmsted, Ann; Wang, Whedy; Lieu, Hsiao; Kaufmann, Philipp A.

doi:10.1016/j.jacc.2007.10.014

Cited by 50 publications

(38 citation statements)

References 7 publications

(5 reference statements)

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“…n/a coronary blood flow, but that the duration of hyperemia was shorter. 64 Regadenoson-induced hyperemic myocardial blood flow measured by PET was not affected by caffeine ingestion, 65 but reversible defects on SPECT myocardial perfusion imaging were smaller with caffeine consumption. 66 Patients should abstain from caffeinated products for at least 12 hours, which allows for selection of any of the three vasodilator stressors.…”

Section: Caffeine and Coronary Vasodilatorsmentioning

confidence: 88%

ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers

Henzlova

Duvall

Einstein

et al. 2016

Journal of Nuclear Cardiology

515

386

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Section: Caffeine and Coronary Vasodilatorsmentioning

confidence: 88%

ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers

Henzlova

Duvall

Einstein

et al. 2016

Journal of Nuclear Cardiology

515

386

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“…32 MBF was measured 2 hours after receiving caffeine or placebo capsules at rest and after administration of a 400 lg IV bolus of regadenoson. 32 The regadenoson-mediated CFR was not significantly different after caffeine (2.75 ± 0.16) or placebo (2.97 ± 0.16) although caffeine blunted the regadenoson-mediated HR increase and did not have an effect on the BP. 32 …”

Section: Effect Of Other Drugsmentioning

confidence: 83%

Selective adenosine agonists and myocardial perfusion imaging

Zoghbi

Iskandrian

2012

Journal of Nuclear Cardiology

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Selective adenosine receptor agonists have several advantages for use as stress agents in conjunction with myocardial perfusion imaging compared to the non selective agents such as adenosine and dipyridamole. This review will summarize the pre-clinical and clinical data on the selective adenosine agonist stress agents regadenoson (Lexiscan(®)), binodenoson (CorVue™) and apadenoson (Stedivaze™) that have been studied so far with focus on regadenoson that has the most clinical data published so far. The article will review the adenosine receptor types and properties. It will also review the various attributes of the selective adenosine agonists including their pharmacology, pharmacokinetics and pharmacodynamics, their coronary vasodilatory and hemodynamic effects, their safety and side effects, their interactions with other drugs and their use with myocardial perfusion imaging. The landmark trials of the selective adenosine agonists will be reviewed as well as their use in special patient populations undergoing stress myocardial perfusion imaging.

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“…9 Gaemperli et al evaluated the effects of caffeine on regadenoson-induced myocardial hyperemia in 41 healthy volunteers randomized to receive either a 200-mg caffeine capsule (equivalent to approximately two standard cups of coffee) or placebo and found no significant difference between the caffeine and placebo groups with respect to myocardial rest (1.13 ± .04 mL/min/g vs 1.06 ± .05 mL/min/g) and stress (2.98 ± .14 mL/min/g vs 3.05 ± .14 mL/min/g). 10 This important study suggests that a moderate amount of caffeine may have only a relatively small impact on regadenoson-induced vasodilation. However it is currently recommended that patients avoid caffeine for at least 12 h prior to administration until this has been studied further.…”

Section: Effect Of Caffeine Ingestionmentioning

confidence: 99%