Interaction of bile acids and cholesterol with non-systemic agents having hypocholesterolemic properties

Stedronsky, Erwin R.

doi:10.1016/0005-2760(94)90230-5

Cited by 85 publications

(44 citation statements)

References 177 publications

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“…Increased blood lipid and serum cholesterol concentra tions contribute to the etiology of cardiovascular dis ease (1). The possibility of lowering the plasma cholesterol concentration by interfering with the absorption of cholesterol and bile acids has been exten sively investigated using either compounds of natural origin (e.g., gel-forming fibers, resistant starch, phy tosterols, and saponins) or synthetic remedies such as cholestyramine (2).…”

mentioning

confidence: 99%

Resistant Starches of Beans Reduce the Serum Cholesterol Concentration in Rats

Han

Fukushima

Shimizu

et al. 2003

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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confidence: 99%

Resistant Starches of Beans Reduce the Serum Cholesterol Concentration in Rats

Han

Fukushima

Shimizu

et al. 2003

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…This suggests that potato and soy peptides are effective in depressing the absorption of exogenous cholesterol in rats. The mechanisms of inhibition of cholesterol absorption, in which viscosity is an important contributor, have been well documented; they include disturbance of micelle formation [12,35], slowing of cholesterol transfer to the brush border across the unstirred layer, and inhibition of ileal bile acid reabsorption [36]. However, the differences observed in the mRNA level, faecal sterol excretion, and serum lipids between the two peptide diets may be due to the differences in amino acid sequences, and support the hypothesise that the two peptide preparations are acting via two different mechanisms [11].…”

Section: Discussionmentioning

confidence: 99%

Potato and soy peptides alter caecal fermentation and reduce serum non‐HDL cholesterol in rats fed cholesterol

Liyanage

Han

Shimada

et al. 2009

Euro J Lipid Sci & Tech

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We examined the effect of potato peptides (PPC) in rats fed a cholesterol-enriched diet, in comparison with two cholesterol-enriched diets containing soy peptides (SPC) or casein (CNC), and a cholesterolfree diet containing casein (CN) for 4 weeks. The serum non-high-density lipoprotein (HDL) cholesterol level was lower in the PPC-(-18.39%) and SPC-fed (-32.76%) groups (p ,0.05) than in the CNC-fed group at the end of the feeding period. The low-density lipoprotein receptor mRNA level in the PPC-fed group, and cholesterol 7a-hydroxylase and scavenger receptor class B type 1 mRNA levels in the SPC-fed group, were higher (p ,0.05) than in the CN-and CNC-fed groups. Faecal neutral sterol and caecal short-chain fatty acid concentrations in the PPC-and SPC-fed groups were higher (p ,0.05) than in the CN-and CNC-fed groups. The faecal total acidic sterol concentration was higher in the SPC-fed group than in the CN-and PPC-fed groups. Caecal anaerobe and Bifidobacterium populations were higher (p ,0.05) in the PPC-and SPC-fed groups than in the CN-fed group. This study suggests that potato peptides, as soy peptides, alter caecal fermentation and steroid absorption and reduce the serum non-HDL cholesterol level in rats fed cholesterol.

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“…However, this polymeric resin also binds anionic drugs, vitamins, and salts ( Johansson et al 1978;Harmon & Seifert 1991). The competition for cholestyramine binding sites in the digestive tract decreases the binding capacity for bile acids, so large doses are required for the effective sorption (Stedronsky 1994). In some patients, the large doses of cholestyramine required to produce the desired cholesterol level lowering can cause serious side effects.…”

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confidence: 99%

Sodium cholate sorption on N-octadecylpectinamide in comparison with cholestyramine

Synytsya¹,

Fesslova²,

Marounek³

et al. 2007

Czech J. Food Sci.

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N-Octadecylpectinamide is hydrophobically modified HM citrus pectin. Previously, it had been prepared by heterogeneous amino-de-alkoxylation of initial pectin with n-octadecylamine in dimethylsulphoxide and characterised as potential hydrophobic sorbent and cholesterol lowering agent. The sorption properties of N-octadecylpectinamide were analysed in comparison with cholestyramine, an effective bile acid sequestrant. Sorption experiments were carried out using sodium cholate as a model bile acid. Cholate concentration was estimated by enzymatic spectroscopic method. Sorption kinetics curves and sorption isotherms of both sorbents were constructed and analysed.

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Interaction of bile acids and cholesterol with non-systemic agents having hypocholesterolemic properties

Cited by 85 publications

References 177 publications

Resistant Starches of Beans Reduce the Serum Cholesterol Concentration in Rats

Resistant Starches of Beans Reduce the Serum Cholesterol Concentration in Rats

Potato and soy peptides alter caecal fermentation and reduce serum non‐HDL cholesterol in rats fed cholesterol

Sodium cholate sorption on N-octadecylpectinamide in comparison with cholestyramine

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