Interaction of BDE-47 with nuclear receptors (NRs) based on the cytotoxicity: In vitro investigation and molecular interaction

Song, Jiayi; Li, Yunxiu; Zhao, Chunyan; Zhou, Qunfang; Zhang, Jianqing

doi:10.1016/j.ecoenv.2020.111390

Cited by 8 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, 10 of the most abundant peptides in RPP were selected for molecular docking with the Keap1 protein, and the Nrf2 protein was used as a control to explore the interaction ability of these peptides with the Keap1 protein. Table shows the ZDOCK scores of peptides docked with the Keap1 protein, which represented the interaction ability of the receptor protein with the ligands . The higher the value, the greater the interaction strength.…”

Section: Resultsmentioning

confidence: 99%

“…Table 4 shows the ZDOCK scores of peptides docked with the Keap1 protein, which represented the interaction ability of the receptor protein with the ligands. 46 The higher the value, the greater the interaction strength. The molecular docking graphics of the Nrf2 protein and the top five peptides with the highest ZDOCK score are shown in Figure 1J (rest of all are shown in Figure S1A).…”

Section: Journal Of Agricultural and Foodmentioning

confidence: 99%

See 1 more Smart Citation

Rice Protein Peptides Alleviate Dextran Sulfate Sodium-Induced Colitis via the Keap1–Nrf2 Signaling Pathway and Regulating Gut Microbiota

Yang

Huang

Xiong

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD), with increasing incidence, causes a range of gastrointestinal symptoms and brings distress and impact on the health and lives of patients. The aim of this study was to explore the protective effects of industrially produced rice protein peptides (RPP) on dextran sulfate sodium (DSS)-induced acute colitis in mice and the potential mechanisms. The results showed that RPP treatment alleviated the symptoms of colitis in mice, including weight loss, colon shortening, and injury, decreased the level of disease activity index (DAI), regulated the balance of inflammatory factors and oxidation, activated Kelch-like ECH-associating protein 1 (Keap1)-nuclear factor E2-related factor 2 (Nrf2) signaling pathway, regulated the expression of related antioxidant proteases, and promoted the expression of intestinal tight junction proteins. In addition, RPP maintained intestinal mucosal barrier function and alleviated acute colitis caused by DSS treatment in mice by increasing the value of F/B, increasing the relative abundance of beneficial bacteria such as Akkermansia, and regulating the level of short-chain fatty acids. In conclusion, RPP alleviated colitis symptoms through the Keap1–Nrf2 signaling pathway and regulating gut microbiota, which had the potential as dietary supplements or functional foods.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Journal Of Agricultural and Foodmentioning

confidence: 99%

Rice Protein Peptides Alleviate Dextran Sulfate Sodium-Induced Colitis via the Keap1–Nrf2 Signaling Pathway and Regulating Gut Microbiota

Yang

Huang

Xiong

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…The EDCs used in this study act through different hormonal pathways, including those mediated by nuclear hormone receptors such as estrogen receptors (e.g., PCBs, BPA, BPS; [ 75 , 76 ]), androgen receptors (e.g., vinclozolin, phthalates; [ 77 , 78 ]), PPARγ (perfluorinated compounds; [ 79 ]), and aryl hydrocarbon receptors (PCB-153, PBDE-47; [ 80 , 81 ]), among others. Perfluorinated chemicals such as PFOS likely act through other families of receptors, with actions mediated by both nuclear (e.g., PPARs: [ 82 ]; ERα: [ 83 ]) and membrane receptors, including non-genomic estrogen receptors [ 84 ] and GPR40 [ 85 ].…”

Section: Discussionmentioning

confidence: 99%

Prenatal Exposure to an EDC Mixture, NeuroMix: Effects on Brain, Behavior, and Stress Responsiveness in Rats

Gore

Moore

Groom

et al. 2022

Toxics

View full text Add to dashboard Cite

Humans and wildlife are exposed to endocrine-disrupting chemicals (EDCs) throughout their lives. Environmental EDCs are implicated in a range of diseases/disorders with developmental origins, including neurodevelopment and behavior. EDCs are most often studied one by one; here, we assessed outcomes induced by a mixture designed to represent the real-world situation of multiple simultaneous exposures. The choice of EDCs, which we refer to as “NeuroMix,” was informed by evidence for neurobiological effects in single-compound studies and included bisphenols, phthalates, vinclozolin, and perfluorinated, polybrominated, and polychlorinated compounds. Pregnant Sprague Dawley rats were fed the NeuroMix or vehicle, and then offspring of both sexes were assessed for effects on postnatal development and behaviors and gene expression in the brain in adulthood. In order to determine whether early-life EDCs predisposed to subsequent vulnerability to postnatal life challenges, a subset of rats were also given a stress challenge in adolescence. Prenatal NeuroMix exposure decreased body weight and delayed puberty in males but not females. In adulthood, NeuroMix caused changes in anxiety-like, social, and mate preference behaviors only in females. Effects of stress were predominantly observed in males. Several interactions of NeuroMix and stress were found, especially for the mate preference behavior and gene expression in the brain. These findings provide novel insights into how two realistic environmental challenges lead to developmental and neurobehavioral deficits, both alone and in combination, in a sex-specific manner.

show abstract

BDE-47-mediated cytotoxicity via autophagy blockade in 3D HepaRG spheroids cultured in alginate microcapsules

Miranda,

Guarache,

Leão

et al. 2024

Chemico-Biological Interactions

View full text Add to dashboard Cite

Interaction of BDE-47 with nuclear receptors (NRs) based on the cytotoxicity: In vitro investigation and molecular interaction

Cited by 8 publications

References 34 publications

Rice Protein Peptides Alleviate Dextran Sulfate Sodium-Induced Colitis via the Keap1–Nrf2 Signaling Pathway and Regulating Gut Microbiota

Rice Protein Peptides Alleviate Dextran Sulfate Sodium-Induced Colitis via the Keap1–Nrf2 Signaling Pathway and Regulating Gut Microbiota

Prenatal Exposure to an EDC Mixture, NeuroMix: Effects on Brain, Behavior, and Stress Responsiveness in Rats

BDE-47-mediated cytotoxicity via autophagy blockade in 3D HepaRG spheroids cultured in alginate microcapsules

Contact Info

Product

Resources

About