Interaction of Aurothiomalate and Cystine

Danpure, Christopher J.; Lawson, Kurt

doi:10.1042/bst0051366

Cited by 3 publications

(1 citation statement)

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“…It has been shown previously (Danpure, 1976a) that, although aurothiomalate reacts slowly with albumin in fresh human serum, the gold-albumin complexes formed are very stable. The reaction probably involves the free thiol of mercaptalbumin (Gerber, 1974;Danpure, 1976a, b) in the first instance and possibly the masked disulphide derivative (Danpure, 1976a(Danpure, , 1977aDanpure and Lawson, 1977) subsequently, yielding a total of 1 gold-binding site per albumin molecule (Danpure, 1976a).…”

Section: In Vitromentioning

confidence: 99%

Distribution of gold among plasma fractions in rheumatoid patients undergoing chrysotherapy compared with its distribution in plasma incubated with aurothiomalate in vitro.

Danpure¹,

Fyfe²,

Gumpel³

1979

Annals of the Rheumatic Diseases

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Section: In Vitromentioning

confidence: 99%

Distribution of gold among plasma fractions in rheumatoid patients undergoing chrysotherapy compared with its distribution in plasma incubated with aurothiomalate in vitro.

Danpure¹,

Fyfe²,

Gumpel³

1979

Annals of the Rheumatic Diseases

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Gold Compounds and Their Applications in Medicine

2009

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Formation and characterization of aurothioneins: Au,Zn,Cd-thionein, Au,Cd-thionein, and (thiomalato-Au)x-thionein

Laib¹,

Shaw²,

Petering³

et al. 1985

Biochemistry

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Three gold-containing thioneins (Au,Zn,Cd-Th, Au,Cd-Th, and (TmSAu)chi Th, where Th = thionein and TmS = thiomalate) have been prepared by the reactions of horse kidney Zn,Cd-thionein with gold thiomalate (AuSTm). When thionein was present in excess, the thiomalate ligand was displaced and the protein chelated the gold in a bidentate fashion. Primarily zinc but also some cadmium was displaced to form Au,Zn,Cd-Th or Au,Cd-Th. Excess AuSTm reacted to form (TmSAu)chi-thionein with monodentate coordination of the protein to each bound gold, retention of the thiomalate, loss of zinc and cadmium, and an increase in the Stokes radius of the product. EXAFS/XANES studies of Au,Zn,Cd-Th and (TmSAu)chi Th established that the oxidation states and coordination environments of gold were Au(I)S2 and that the gold-sulfur bond distances were 229 and 230 pm, respectively. Radioimmunoassay established that the aurothioneins retained their antigenicity to native metallothionein antibodies. Metal exchange reactions with gold were complete within 5-10 min when Zincon or 4-(2-pyridylazo) resorcinol was used to monitor Cd2+ and Zn2+ displacement.

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Interaction of Aurothiomalate and Cystine

Cited by 3 publications

References 0 publications

Distribution of gold among plasma fractions in rheumatoid patients undergoing chrysotherapy compared with its distribution in plasma incubated with aurothiomalate in vitro.

Distribution of gold among plasma fractions in rheumatoid patients undergoing chrysotherapy compared with its distribution in plasma incubated with aurothiomalate in vitro.

Gold Compounds and Their Applications in Medicine

Formation and characterization of aurothioneins: Au,Zn,Cd-thionein, Au,Cd-thionein, and (thiomalato-Au)x-thionein

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