Interaction of auditory and pain pathways: Effects of stimulus intensity, hearing loss and opioid signaling

Manohar, Senthilvelan; Adler, Henry J.; Radziwon, Kelly E.; Salvi, Richard

doi:10.1016/j.heares.2020.108012

Cited by 8 publications

(3 citation statements)

References 105 publications

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“…Thus, this suggests that misophonia and SOR are two distinct conditions, differing in their behavioral responses to painful and non-painful stimuli. Findings allude to future exploration of the pain, auditory analgesia, and auditory hyperalgesia neurophysiological mechanisms in misophonia ( Manohar et al, 2020 ).…”

Section: Discussionmentioning

confidence: 91%

Opening a window into the riddle of misophonia, sensory over-responsiveness, and pain

et al. 2022

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IntroductionMisophonia and sensory over-responsiveness (SOR) share physiological and psychological symptoms. While individuals with SOR demonstrate pain perception alterations, these were not explored in misophonia.MethodsThis exploratory study comprised thirty healthy adults with (n = 15; based on the Misophonia Questionnaire) and without misophonia. The Sensory Responsiveness Questionnaire (SRQ) was used for evaluating sensory responsiveness. In addition, psychophysical tests were applied for quantification of: (i) stimulus-response function of painful stimuli, (ii) the individual perceived pain intensity, (iii) pain modulation efficiency, (iv) auditory intensity discrimination capability, and (v) painful and unpleasantness responses to six ecological daily sounds using the Battery of Aversiveness to Sounds (BAS).ResultsIndividuals with misophonia reported higher scores in the SRQ-Aversive (p = 0.022) and SRQ-Hedonic (p = 0.029) scales as well as in auditory (p = 0.042) and smell (p = 0.006) sub-scales, indicating higher sensory responsiveness. Yet they were not identified with the SOR type of sensory modulation dysfunction. Groups did not differ in the pain psychophysical tests, and in auditory discrimination test scores (p > 0.05). However, in the misophonia group the BAS evoked higher pain intensity (p = 0.046) and unpleasantness (p <0.001) ratings in the apple biting sound, and higher unpleasantness rating in the scraping a dish sound (p = 0.007), compared to the comparison group.ConclusionFindings indicate increased sensory responsiveness in individuals with misophonia, yet not defined as SOR. Thus, this suggests that misophonia and SOR are two distinct conditions, differing in their behavioral responses to painful and non-painful stimuli.

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Section: Discussionmentioning

confidence: 91%

Opening a window into the riddle of misophonia, sensory over-responsiveness, and pain

et al. 2022

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“…It has been suggested that the normal hearing thresholds of adult mice are approximately 25 dB 36 , but under isoflurane anesthesia, the thresholds are elevated by ~27 dB on average 37 . A recent study showed that noise above 90 dB increases pain sensitivity in rats 38 . In this study, we found that exposure to 70–100 dB could induce more serious hyperpathia in mice undergoing plantar incision under general anesthesia than exposure to 40 dB, which is close to the background noise level recommended by the WHO.…”

Section: Discussionmentioning

confidence: 97%

Effect of intraoperative noise on postoperative pain in surgery patients under general anesthesia: Evidence from a prospective study and mouse model

You,

Xu,

Zhu

et al. 2023

International Journal of Surgery

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Background: Most patients are in a noisy environment during abdominal surgery under general anesthesia. This study included patients who underwent abdominal surgery under general anesthesia and established an animal model to determine whether intraoperative noise affects postoperative pain. Materials and Methods: This prospective study included 200 patients who underwent abdominal surgery under general anesthesia. Intraoperative noise and electroencephalograms were continuously recorded, and the mean level and time proportion of noise intensity of >70 dB were calculated. Maximum postoperative pain was assessed using a numerical rating scale (NRS) at 0–12 h and 12–24 h after surgery, and postoperative analgesia consumption in patients receiving patient-controlled intravenous analgesia was recorded. Postoperative pain intensity and electroencephalogram amplitude were compared between patients with high-noise exposure (time proportion of noise intensity greater than 70 dB ≥40%) and low-noise exposure (<40%). Mechanical pain sensitivity was tested in two groups of mice with plantar incisions exposed to 40 dB or 70–100 dB. Results: The time proportion of noise intensity >70 dB was identified as an independent risk factor for postoperative pain intensity (P<0.001). Pain NRS 0–12 h (4.5±1.5 vs. 3.7±1.3, P=0.001) and 12–24 h (3.9±1.5 vs. 3.2±1.1, P=0.004) after surgery in patients with high-noise exposure was significantly higher than in patients with low-noise exposure. The electroencephalogram amplitude of patients with high-noise exposure was significantly lower than that of patients with low-noise exposure (P<0.05). In the mouse model, mechanical hyperalgesia in the 70–100 dB group was significantly greater than that in the 40 dB group (P<0.001). Conclusion: High-level intraoperative noise exposure aggravates the degree of postoperative pain and analgesic needs of patients undergoing abdominal surgery, which may be related to the impact of noise on the neurophysiological activity of the brain and postoperative hyperalgesia.

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“…As is known, increased noise exposure (via higher sound levels or longer exposure) raises the risk of noise injury, which may compromise hearing or other suprathreshold sound processing abilities [14]. Most people repeatedly exposed to more than 105 dBA will have permanent hearing loss to some extent [15], and pain may even be felt in the ear in the presence of noise with a level above 120 dB [16]. In addition to hearing loss, noise exposure has been implicated in a wide range of major noise-associated noncommunicable diseases, including cardiovascular disease, metabolic disease, cancer, and respiratory disease [1].…”

Section: Noise Exposure and Human Healthmentioning

confidence: 99%

Experimental Evaluation of Noise Exposure Effects on Subjective Perceptions and Cognitive Performance

Zhang,

Pang,

Yang

et al. 2024

Buildings

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Individuals exposed to elevated noise levels experience heightened emotional intensity, leading to increased cognitive disruption and a higher likelihood of accidents. This study seeks to investigate the impact of noise exposure on human cognitive performance, and the moderating role of emotion. Twelve healthy male college-age students underwent exposure to three noise conditions, each characterized by different sound pressure levels and sharpness. Each condition included an initial acoustic/thermal adaption period lasting approximately 40 min, followed by intermittent questionnaire tests and a battery of computerized cognitive tests. Statistical analysis revealed that reducing noise levels proved advantageous, enhancing perceived sound quality, positive emotions, and auditory perception abilities, while concurrently reducing false alerts and accelerating execution speed. Many of these effects were found to be counteracted by elevated sharpness. Correlation analyses and partial least squares structural equation modeling (PLS-SEM) results suggested that human emotions mediate the relationship between noise exposure and cognitive performance. The potential underlying mechanism suggests that negative feelings towards noise contribute to poor emotional states, subsequently influencing cognitive processes and impairing executive function. The outcomes of this study provide valuable insights into the mechanism of noise exposure and its effects on human cognition and subjective perceptions.

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Interaction of auditory and pain pathways: Effects of stimulus intensity, hearing loss and opioid signaling

Cited by 8 publications

References 105 publications

Opening a window into the riddle of misophonia, sensory over-responsiveness, and pain

Opening a window into the riddle of misophonia, sensory over-responsiveness, and pain

Effect of intraoperative noise on postoperative pain in surgery patients under general anesthesia: Evidence from a prospective study and mouse model

Experimental Evaluation of Noise Exposure Effects on Subjective Perceptions and Cognitive Performance

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