Interaction of Atmospheric-Pressure Air Microplasmas with Amino Acids as Fundamental Processes in Aqueous Solution

Zhou, Renwu; Zhou, Rusen; Zhuang, Jinxing; Zong, Zichao; Zhang, Xianhui; Liu, Dongping; Bazaka, Kateryna; Ostrikov, Kostya Ken

doi:10.1371/journal.pone.0155584

Cited by 104 publications

(83 citation statements)

References 46 publications

(45 reference statements)

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“…The low efficiency, the requirement of pure gases, and the limited volume of liquid that can be treated make plasma-treated water (PTW) expensive and its use in medicine and agriculture impossible. The most promising method for effective and low-cost production of PTW is treating liquids with high-density plasma generated by using air as a process gas [3,18,[23][24][25][26]. Furthermore, it may be possible to scale up production and reduce the cost of PTW by applying plasmas generated in ambient air to treat a continuous flow of liquid.…”

Section: Introductionmentioning

confidence: 99%

Direct Treatment of Liquids Using Low-Current Arc in Ambient Air for Biomedical Applications

et al. 2019

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In this work, we developed a portable device with low production and operation costs for generating an ambient air low-current arc (AALCA) that is transferred to the surface of a treated liquid. It was possible to generate a stable discharge, irrespective of the conductivity of the treated liquid, as a sequence of corona, repeating spark, and low-current arc discharges. The estimated concentration of reactive oxygen and nitrogen species (RONS) in plasma-treated water (PTW) produced using AALCA treatment was two orders of magnitude higher than that of PTW produced using conventional He nonequilibrium atmospheric pressure plasma jets or dielectric barrier discharges. The strong bactericidal effect of the treatment using AALCA and the water treated using AALCA was confirmed by survival tests of Escherichia coli. Further, the possibility of treating a continuous flow of liquid using AALCA was demonstrated.

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Section: Introductionmentioning

confidence: 99%

Direct Treatment of Liquids Using Low-Current Arc in Ambient Air for Biomedical Applications

et al. 2019

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“…2 739. Briefly, the plasma device consists of 29 microplasma jet units housed in a glass cup (inner diameter: 50 mm).…”

Section: Methodsmentioning

confidence: 99%

Synergistic Effect of Atmospheric-pressure Plasma and TiO2 Photocatalysis on Inactivation of Escherichia coli Cells in Aqueous Media

Zhou

Zhang

et al. 2016

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Atmospheric-pressure plasma and TiO2 photocatalysis have been widely investigated separately for the management and reduction of microorganisms in aqueous solutions. In this paper, the two methods were combined in order to achieve a more profound understanding of their interactions in disinfection of water contaminated by Escherichia coli. Under water discharges carried out by microplasma jet arrays can result in a rapid inactivation of E. coli cells. The inactivation efficiency is largely dependent on the feed gases used, the plasma treatment time, and the discharge power. Compared to atmospheric-pressure N2, He and air microplasma arrays, O2 microplasma had the highest activity against E. coli cells in aqueous solution, and showed >99.9% bacterial inactivation efficiency within 4 min. Addition of TiO2 photocatalytic film to the plasma discharge reactor significantly enhanced the inactivation efficiency of the O2 microplasma system, decreasing the time required to achieve 99.9% killing of E. coli cells to 1 min. This may be attributed to the enhancement of ROS generation due to high catalytic activity and stability of the TiO2 photocatalyst in the combined plasma-TiO2 systems. Present work demonstrated the synergistic effect of the two agents, which can be correlated in order to maximize treatment efficiency.

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“…The most likely modification is different forms of oxidations. It has been shown that the relative reactivity of amino acids exposed to plasma treatment follows the order Met > Cys > Trp > Phe > Tyr > His [37]. The high-sequence coverage and redundancy obtained by pepsin digestion as applied in HDX-MS provides a suitable technique for investigation of oxidative modifications introduced by CAP treatment of the streptococcal virulence factor M1.…”

Section: Cap Induces Oxidation Of M1 Proteinmentioning

confidence: 99%

Cold Atmospheric Plasma Disarms M1 Protein, an Important Streptococcal Virulence Factor

et al. 2019

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Cold atmospheric plasma (CAP) has been demonstrated to be a successful antiseptic for chronic and infected wounds. Although experimental work has focused on elucidation of the curative power of CAP for wound healing, the molecular mechanisms behind this ability are less understood. To date, the direct effect of CAP on the activity of microbial virulence factors has not been investigated. In the present study, we therefore examined whether CAP can modulate the detrimental activity of M1 protein, one of the most studied Streptococcus pyogenes virulence determinant. Our results show that CAP abolishes the ability of M1 protein to trigger inflammatory host responses. Subsequent mass spectrometric analysis revealed that this effect was caused by oxidation of Met81 and Trp128 located at the sub-N-terminal region of M1 protein provoking a conformational change. Notably, our results also show that CAP has an insignificant effect on the host immune system, supporting the benefits of using CAP to combat infections. Considering the growing number of antibiotic-resistant bacteria, novel antimicrobial therapeutic approaches are urgently needed that do not bear the risk of inducing additional resistance. Our study therefore may open new research avenues for the development of novel approaches for the treatment of skin and wound infections caused by S. pyogenes.

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Interaction of Atmospheric-Pressure Air Microplasmas with Amino Acids as Fundamental Processes in Aqueous Solution

Cited by 104 publications

References 46 publications

Direct Treatment of Liquids Using Low-Current Arc in Ambient Air for Biomedical Applications

Direct Treatment of Liquids Using Low-Current Arc in Ambient Air for Biomedical Applications

Synergistic Effect of Atmospheric-pressure Plasma and TiO2 Photocatalysis on Inactivation of Escherichia coli Cells in Aqueous Media

Cold Atmospheric Plasma Disarms M1 Protein, an Important Streptococcal Virulence Factor

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