Interaction of anticancer drug methotrexate with DNA analyzed by electrochemical and spectroscopic methods

Studying non-covalent drug–DNA interactions

“…There is an extensive broadening of different peaks in the presence of DNA due to intercalation of chlorobenzylidine in the DNA helix. NMR technique is regularly used in different studies [83,84]. Figure is reproduced with permission from the manuscript of Zhong et al [85].…”

Detection of Aeromonas hydrophila DNA oligonucleotide sequence using a biosensor design based on Ceria nanoparticles decorated reduced graphene oxide and Fast Fourier transform square wave voltammetry

“…Square wave voltammetry (SWV) is a sensitive electrochemical technique that has been extensively used as detection technique in designing biosensors [21][22][23]. In SWV measurements, the detection limits can be drastically improved.…”

DNA-binding studies of complex of Pt(bpy)(pip)]2+ and [Pt(bpy)(hpip)]2+ by electrochemical methods: development of an electrochemical DNA biosensor

“…Covalent attachment, physical adsorption, self-assembly and electrostatic interaction have widely been used for the immobilization of DNA [17][18][19]. Different types of instrumental techniques, such as gel electrophoresis, foot printing technique, UV and fluorescent spectroscopy, etc., have extensively been used to bring a further insight into the interaction and binding properties of metal complexes with DNA [20]. Since electrochemical techniques are simple, inexpensive, rapid and highly sensitive and accurate, they have widely been preferred to shed a light onto the binding mechanism of metal complexes with DNA [1,21].…”