Interaction of antibiotics with membranes: Chlorothricin

Pache, W.; Chapman, D.

doi:10.1016/0005-2736(72)90033-8

Cited by 44 publications

(10 citation statements)

References 25 publications

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“…Another possibility is that the action of etruscomycin alters the membrane and thus inhibits the release of ADP (after the collagen-platelet interaction). This is in accordance with the ideas of Pache and Chapman [19] who assume a changed fluidity of lipid chains in bilayers under such conditions. Pimaricin did not have any influence on collagen-and ADP-induced aggregation up to 2.5 x 10 4 m. Also this polyene does not possess the other effects of filipin and nystatin.…”

Section: Discussionsupporting

confidence: 74%

Effects of Some Polyene Antibiotics on Human Platelets and their Function

Plas¹,

Kraan²,

Stibbe³

et al. 1972

Pathophysiol Haemos Thromb

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(1) Polyenes aggregate platelets. The aggregation power diminishes in the following order: filipin > nystatin > etruscomycin∼pimaricin. (2) In the case of filipin, aggregation is probably caused by damage to platelets resulting in a release of platelet contents, which subsequent aggregates the remaining platelets. (3) Filipin-induced aggregation can be partially inhibited by adenosine and is Ca⁺⁺-dependent. (4) Collagen- and ADP-induced aggregation can be inhibited by low concentrations of etruscomycin. (5) Polyenes are able to release platelet factor 3 from thrombocytes. The strength decreases in the following order: filipin > nystatin > etruscomycin > pimaricin. (6) The uptake of serotonin by platelets is diminshed by polyenes. Leakage of ⁸⁶Rb from preloaded platelets increases upon addition of polyenes.

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Section: Discussionsupporting

confidence: 74%

Effects of Some Polyene Antibiotics on Human Platelets and their Function

Plas¹,

Kraan²,

Stibbe³

et al. 1972

Pathophysiol Haemos Thromb

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“… 82 It should be noted, however, that the direct cellular target of 1 is under debate and may involve interaction with components in the cell membrane that may account for the observed downstream effects. 83 …”

Section: Biology Of Spirotetronate Polyketidesmentioning

confidence: 99%

Spirotetronate Polyketides as Leads in Drug Discovery

Lacoske

Theodorakis

2014

J. Nat. Prod.

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The discovery of chlorothricin (1) defined a new family of microbial metabolites with potent antitumor antibiotic properties collectively referred to as spirotetronate polyketides. These microbial metabolites are structurally distinguished by the presence of a spirotetronate motif embedded within a macrocyclic core. Glycosylation at the periphery of this core contributes to the structural complexity and bioactivity of this motif. The spirotetronate family displays impressive chemical structures, potent bioactivities, and significant pharmacological potential. This review groups the family members based on structural and biosynthetic considerations and summarizes synthetic and biological studies that aim to elucidate their mode of action and explore their pharmacological potential.

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“…Some of these same antibiotics exert regulatory activity in the cell division of other organisms. Antibiotics have been shown to have an effect on the cell membrane (28,29,36,40), the proposed site of regulation of cross-wall formation. Direct structural differences in membrane proteins have been correlated with cell division (9,20,38).…”

Section: Discussionmentioning

confidence: 99%

Mechanism for the Regulation of Cell Division inAgmenellum

Ingram

Fisher

1973

J Bacteriol

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We describe a nonlethal temperature-conditional mutant of Agmenellum quadruplicatum which allows dissociation of the processes of growth and cell division. With this system, evidence has been obtained for the regulation of one step in the process of cell division by a small effector molecule. The effector molecule is apparently released into the surrounding medium and can be obtained from lyophilized spent medium by extraction with 80% ethanol. The addition of this extract to serpentine filaments of the SN29 mutant strain stimulates cell division in these filaments and leads to the production of cells approximating normal dimensions within one generation time. The degree of stimulation of cell division is directly related to the amount of extract added. A general hypothesis is presented for the positive regulation of the initiation of cell wall and cell membrane invagination in this organism.

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Interaction of antibiotics with membranes: Chlorothricin

Cited by 44 publications

References 25 publications

Effects of Some Polyene Antibiotics on Human Platelets and their Function

Effects of Some Polyene Antibiotics on Human Platelets and their Function

Spirotetronate Polyketides as Leads in Drug Discovery

Mechanism for the Regulation of Cell Division inAgmenellum

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