Interaction of Angiotensin I-Converting Enzyme Insertion-Deletion Polymorphism and Daily Salt Intake Influences Hypertension in Japanese Men

Zhang, Ling; Miyaki, Koichi; Araki, Jungo; Song, Yingliang; Kimura, Tomomi; Omae, Kazuyuki; Muramatsu, Masaaki

doi:10.1291/hypres.29.751

Cited by 42 publications

(29 citation statements)

References 53 publications

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“…The level of sodium intake determined using the FFQ method has been shown to exhibit a good correlation with the level of urinary sodium in men (correlation coefficient=0.66) (29). Based on these previous observations, the FFQ can be considered an objective investigation method with both propriety and plasticity (15,30,31).…”

Section: Discussionmentioning

confidence: 94%

High Salt Intake is Associated with Renal Involvement in Japanese Patients with Type 2 Diabetes Mellitus

et al. 2015

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Objective The aim of our study was to investigate clinical and nutritional factors associated with renal involvement in patients with type 2 diabetes. Patients We performed a cross-sectional study of 71 patients with type 2 diabetes who were being educated at our hospital from September 2006 to February 2008. The patients were divided into two groups; Group I consisted of 40 patients with both an estimated glomerular filtration rate (eGFR) of ! 60 mL/min/1.73 m 2 and normoalbuminuria, and Group II consisted of 31 patients with either microalbuminuria/overt proteinuria or an eGFR of <60 mL/min/1.73 m 2 . We compared the age, body mass index (BMI), blood pressure, duration from onset of diabetes, use of hypoglycemic agents and insulin, biochemistry data, including HbA1c, pulse wave velocity corrected by blood pressure (PWVc) and the daily intake of several nutrients between the two groups. A multivariate logistic regression analysis was performed to identify factors independently associated with renal involvement. Results Group II had significantly higher values for BMI, the duration of diabetes, triglycerides, uric acid and PWVc than Group I. Group II tended to have a high salt intake compared to Group I. The multivariate logistic analysis revealed that the daily salt intake, PWVc and uric acid were independent factors associated with renal involvement (odds ratio, 1.15, 1.84 and 2.00; 95% confidence interval, 1.02-1.31, 1.04-3.27 and 1.04-3.85, respectively). Conclusion Our data suggest that a high salt intake, in addition to arteriosclerosis, is associated with renal involvement in our cohort with type 2 diabetes.

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Section: Discussionmentioning

confidence: 94%

High Salt Intake is Associated with Renal Involvement in Japanese Patients with Type 2 Diabetes Mellitus

et al. 2015

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“…Details of the study population were described elsewhere. 13 Owing to the small number of women (n ¼ 37), they were excluded from the analysis. We also excluded those who are currently under treatment for hypertension (n ¼ 38), diabetes (n ¼ 8) and hyperlipidemia (n ¼ 8).…”

Section: Subjectsmentioning

confidence: 99%

CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men

2009

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“…A polymorphism of ACE gene involves the insertion (I) and deletion (D) of 287 bp Alu repeat sequence near the 3' end of the intron. Physiologically it has been reported ACE I/D accounts for 50% of the inter-individual variability of plasma ACE concentration [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Association of High Altitude Hypertension with Angiotensin Converting Enzyme (ACE) Gene Insertion/Deletion Polymorphism

Ch¹,

Doza²,

Kumar³

2017

UNOAJ

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The study included ACE gene I/D polymorphism and its association between high altitude hypertension. Genetic, biochemical, anthropometric and Physiometeric results were analyzed using statistical software. The results were non-significant for I/D polymorphism.Objective: ACE is the major enzyme of hypertension and with most commonly reviewed I/D polymorphism. High-altitude exposes various physiological and biochemical changes, which contributes a rise in systemic blood pressure of the body. There are very few studies available in North-India, with a core focus on the high altitude hypertension. Therefore, a current study supported an interest to find out the association of high altitude hypertension with ACE gene I/D polymorphism.Methods: to study the significant association with respect to altitude, genetic, biochemical, anthropometric and physio-metric comparison were conducted among 98 individuals where 489nbeing hypertensive patients and other half being normotensive, inclusive of both males and females. The entire results were finally examined and analyzed using statistical software SPSS 16.0 version. Results:According to study results, mean arterial blood pressure and triglycerides were significantly (p<0.05) associated with SBP among both hypertensive and normotensives. Whereas HDL, LDL-HDL ratio, CHO-HDL were significantly associated only among hypertensive, and age, PP, and SpO2 have been significantly (p<0.05) associated with SBP among normotensive, a strong predictor for SBP. Conclusion:The genotypic observations were visibly linked with the disease, however, the results were statistically non-significant (ID/DD vs. II; OR: 0.54, 95% CI: 0.20-1.44, p= 0.217). A further study with considerate knowledge of noteworthy dynamics, mainly, altitude, population size, and ethnicity are recommended.

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Interaction of Angiotensin I-Converting Enzyme Insertion-Deletion Polymorphism and Daily Salt Intake Influences Hypertension in Japanese Men

Cited by 42 publications

References 53 publications

High Salt Intake is Associated with Renal Involvement in Japanese Patients with Type 2 Diabetes Mellitus

High Salt Intake is Associated with Renal Involvement in Japanese Patients with Type 2 Diabetes Mellitus

CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men

Association of High Altitude Hypertension with Angiotensin Converting Enzyme (ACE) Gene Insertion/Deletion Polymorphism

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