Interaction of ADIPOQ Genetic Polymorphism With Blood Pressure and Plasma Cholesterol Level on the Risk of Coronary Artery Disease

Abstract

Background:The protective effect of +45T >G polymorphism in the adiponectin gene (ADIPOQ) on coronary artery disease (CAD) has been demonstrated in European populations, so this study investigated the effect of +45T >G polymorphism on the risk of CAD and its interactions with other metabolic risk factors in a Chinese population. Methods and Results:The +45T >G polymorphism (rs2241766) of ADIPOQ was genotyped in 600 patients with angiographically diagnosed CAD and in 718 controls. The G allele at the +45T >G polymorphism was associated with a lower risk of CAD (odds ratio (OR), 0.76; 95% confidence interval (CI), 0.64-0.89; P=0.001). The protective effect of the G allele at +45T >G polymorphism was magnified at blood pressure <140/90 mmHg (OR, 0.65; 95%CI, 0.51-0.82; P=0.0004), but disappeared at blood pressure ≥140/90 mmHg (OR, 0.98; 95%CI, 0.76-1.28; P=0.93), indicating an interaction between +45T >G polymorphism and blood pressure on CAD risk (P=0.02 for interaction). A similar interaction was also observed between plasma cholesterol level and the +45T >G polymorphism. Conclusions: An association of ADIPOQ genetic polymorphism with CAD risk is modified by traditional risk factors, such as blood pressure and plasma cholesterol level. (Circ J 2009; 73: 1934 -1938

Distribution and genotype frequency of adiponectin (+45 T/G) and adiponectin receptor2 (+795 G/A) single nucleotide polymorphisms in Iranian population

“…One report from French and one from Caucasians showed no significant difference in allelic frequencies (Fumeron et al, 2004;Mackevics et al, 2006). Comparison of allelic and genotypic frequencies of ADIPOQ in 2 reports from Caucasians, one from Americans, and some from Uygurs, Greeks, Swedish and Italians showed no significant differences from our estimates (Cesari et al, 2007;Chang and Jiang, 2009;Panidis et al, 2004;dbSNP database, 2011;Ukkola et al, 2003). Allelic and genotypic frequencies of ADIPOQ in one report from Caucasians (p value = 0.008 ) (Kang et al, 2005), HISP (p value = 0.011) (Li et al, 2007) and a few from Europe such as Spain (p value = 0.001) (Szopa et al, 2009), Poland ( p value = 0.00) (Kaklamani et al, 2008a) and three studies from china (p value = 0.00) (Farjadian et al, 2006), Taiwan (p value = 0.00) (Chang and Jiang, 2009), Korea (p value = 0.00) (Kang et al, 2005) and also two investigations from USA showed significant differences from our data about Iranians.…”

ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease?

“…No association was observed individually with the other SNPs studied. A similar result was observed for Chinese subjects diagnosed with CAD by coronary angiography (600 patients), compared with 718 non-CAD controls (48). The minor G rs2241766 allele had a protective association with CAD, with an OR 0.75 for each copy, after adjustment for classical risk factors not including diabetes, only adjusted for glucose levels.…”

Adiponectin gene (ADIPOQ) polymorphisms correlate with the progression of nephropathy in Taiwanese male patients with type 2 diabetes

“…A few Taiwanese studies have associated the mutant G allele at +45T>G with improved insulin sensitivity [28] and reduced risks of obesity [29] and coronary artery disease [30]. These findings suggest that +45G allele may confer a protective effect against metabolic disease and CVD in the Taiwanese population.…”