Interaction of ABA Block Copolymers with Ionic Surfactants: Influence on Micellization and Gelation

Hecht, E.; Mortensen, K.; Gradzielski, Michael; Hoffmann, H.

doi:10.1021/j100013a068

Cited by 204 publications

(257 citation statements)

References 13 publications

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“…In addition, acidic pHs irreversibly altered the conformations of virus components and inactivated herpesviruses, as demonstrated in vitro (18). The addition of surfactant and salts into the polymer affects its transition temperature (14). Therefore, the concentration of polymer was adjusted for each gel formulation to get a transition temperature close to 28°C.…”

Section: Discussionmentioning

confidence: 99%

Thermoreversible Gel Formulations Containing Sodium Lauryl Sulfate or n -Lauroylsarcosine as Potential Topical Microbicides against Sexually Transmitted Diseases

Roy

Gourde

Piret

et al. 2001

Antimicrob Agents Chemother

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The microbicidal efficacies of two anionic surfactants, sodium lauryl sulfate (SLS) and n-lauroylsarcosine (LS), were evaluated in cultured cells and in a murine model of herpes simplex type 2 (HSV-2) intravaginal infection. In vitro studies showed that SLS and LS were potent inhibitors of the infectivity of HSV-2 strain 333. The concentrations of SLS which inhibit viral infectivity by 50% (50% inhibitory dose) and 90% (90% inhibitory dose) were 32.67 and 46.53 M, respectively, whereas the corresponding values for LS were 141.76 and 225.30 M. In addition, intravaginal pretreatment of mice with thermoreversible gel formulations containing 2.5% SLS or 2.5% LS prior to the inoculation of HSV-2 strain 333 completely prevented the development of genital herpetic lesions and the lethality associated with infection. Of prime interest, no infectious virus could be detected in mouse vaginal mucosa. Both formulations still provided significant protection when viral challenge was delayed until 1 h after pretreatment. Finally, intravaginal application of gel formulations containing 2.5% SLS or 2.5% LS once daily for 14 days to rabbits did not induce significant irritations to the genital mucosa, as demonstrated from macroscopic and histopathologic examinations. These results suggest that thermoreversible gel formulations containing SLS or LS could represent potent and safe topical microbicides for the prevention of HSV-2 and possibly other sexually transmitted pathogens, including human immunodeficiency virus.

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Section: Discussionmentioning

confidence: 99%

Thermoreversible Gel Formulations Containing Sodium Lauryl Sulfate or n -Lauroylsarcosine as Potential Topical Microbicides against Sexually Transmitted Diseases

Roy

Gourde

Piret

et al. 2001

Antimicrob Agents Chemother

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“…It is widely accepted that SDS absorbs into the PPO core as the interaction between SDS and the hydrophobic PPO block of P123 is stronger than that between SDS and the hydrophilic PEO block where it renders the core less hydrophobic [15,16]. Jansson et al [42] showed that at low SDS/P123 mole ratios, the principle structure is a P123 micelle with co-micellised SDS.…”

Section: Effect Of Alcohols On the Pluronic Micelle Structure Scattementioning

confidence: 99%

“…The mixed micelle aggregation number shows variations with changing the small molecule surfactant charge. For the P123/SDS system, the aggregation number decreases after adding SDS to the block copolymer (Nagg = 12 ± 5) [11,15,16,43], which is expected as the head group (SO4Na Figure 5 shows the variations in the scattering data at lower P123 and small molecule surfactant concentrations but at identical P123/surfactant ratio and above surfactants at the same composition, equation (4). For 0.5wt% P123-5 mM SDS, α(SDS) = 31 (±5)% [11], and for 0.5wt% P123-5 mM C12TAB, α(C12TAB) = 11 (±5)%.…”

Section: Effect Of Alcohols On the Pluronic Micelle Structure Scattementioning

confidence: 99%

“…The improvement in performance arises due to the synergistic or antagonistic interactions between the various surfactants [13]. A considerable number of studies have focused on determining the onset of the micellization process and the composition/morphology of the mixed micelles formed [9,[14][15][16], though theoretical modelling is limited to systems that are considerably more simple than generally encountered in 'real-life' formulations [17,18] .…”

Section: Introductionmentioning

confidence: 99%

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Probing competitive interactions in quaternary formulations

Mansour

Cattoz

Heenan

et al. 2015

Journal of Colloid and Interface Science

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Hypothesis: The interaction of amphiphilic block copolymers of the poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) group with small molecule surfactants may be "tuned" by the presence of selected alcohols, with strong interactions leading to substantial changes in (mixed) micelle morphology, whilst weaker interactions lead to coexisting micelle types. Experiments:The nature and the strength of the interactions between Pluronic P123 (EO20PO70EO20) and small molecule surfactants (anionic sodium dodecylsulfate, SDS, C12SO4Na), (cationic dodecyltrimethylammonium bromide, C12TAB) and (non-ionic polyoxyethylene(23)lauryl ether, Brij 35, C12EO23OH) is expected to depend on the partitioning of the short, medium and long chain alcohols (ethanol, hexanol and decanol respectively) and was probed using tensiometry, pulsed-gradient spin-echo nuclear magnetic resonance (PGSE-NMR) and small-angle neutron scattering (SANS). Findings:The SANS data for aqueous P123 solutions with added alcohols were well described by a charged spherical core/shell model for the micelle morphology. The addition of the surfactants led to significantly smaller, oblate elliptical mixed micelles in the absence of alcohols. Addition of ethanol to these systems led to a decrease in the 2 micelle size, whereas larger micelles were observed upon addition of the longer chain alcohols. NMR studies provided complementary estimates of the micelle composition, and the partitioning of the various components into the micelle.

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“…On the other hand, merely increasing the viscosity may make the infusion too difficult to be done in the clinic. To avoid this problem and yet increase the viscosity of virus suspension in tumor tissues, we used poloxamer, a polymer consisting of poly(ethylene oxide) and poly(propylene oxide) units (16,17), as a delivery vehicle. Poloxamer is biocompatible and has been widely used for wound healing, drug and gene delivery, and tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

A Novel Method for Viral Gene Delivery in Solid Tumors

Wang¹,

Liu

et al. 2005

Cancer Research

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Intratumoral infusion is the most commonly used method for viral gene delivery in clinical trials for cancer treatment. However, a potential problem in this approach is that viral vectors may disseminate from tumor to normal tissues during and after the infusion. To reduce the dissemination, we developed a novel method based on a biocompatible polymer, poloxamer 407, which could significantly increase the viscosity of virus suspension when the temperature was changed from 4°C to 37°C. With this method, we could significantly increase transgene expression in solid tumors and reduce virus dissemination by 2 orders of magnitude after intratumoral infusion of adenoviral vectors. The mechanism of reduction was likely to be that the viscous poloxamer solution blocked convection of viral vectors in the interstitial space and the lumen of microvessels in the vicinity of the infusion site. This method has a potential to be used in the clinic for enhancing efficacy and reducing toxicity in viral gene therapy. (Cancer Res 2005; 65(17): 7541-5)

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Interaction of ABA Block Copolymers with Ionic Surfactants: Influence on Micellization and Gelation

Cited by 204 publications

References 13 publications

Thermoreversible Gel Formulations Containing Sodium Lauryl Sulfate or n -Lauroylsarcosine as Potential Topical Microbicides against Sexually Transmitted Diseases

Thermoreversible Gel Formulations Containing Sodium Lauryl Sulfate or n -Lauroylsarcosine as Potential Topical Microbicides against Sexually Transmitted Diseases

Probing competitive interactions in quaternary formulations

A Novel Method for Viral Gene Delivery in Solid Tumors

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