Interaction of a Surface-Active Ionic Liquid with an Antidepressant Drug: Micellization and Spectroscopic Studies

Farooq, Ummer; Patel, Rajan; Ali, Anwar

doi:10.1007/s10953-018-0739-7

Cited by 32 publications

(13 citation statements)

References 54 publications

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“…:

Π_{CMC} = γ_{0} - γ_{CMC}

where γ 0 and γ CMC are the surface tension of pure water and the surface tension at the CMC, respectively. γ CMC can be used to calculate the effectiveness of surfactant to reduce the surface tension of water as an indication of the maximum reduction of surface tension (Chen et al, ; Farooq et al, ). The values of Π cmc are given Table .…”

Section: Resultsmentioning

confidence: 99%

Investigation of Mixing Behavior of both a Conventional Surfactant and Different Inorganic Salts with a Cationic Gemini Surfactant in Aqueous Solution

Sarıkaya

Bilgen

Akbaş

2019

J Surfact & Detergents

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N,N′‐bis [3‐(dodecanoylamino)propyl]‐N,N,N′,N′‐tetramethylhexane‐1,6‐diaminium dibromide is a cationic Gemini surfactant including quaternary ammonium salt with amide groups. Critical micelle concentration (CMC) and some thermodynamic parameters of the cationic Gemini surfactant were investigated using surface tension and conductivity methods. Mixed micellization of binary mixtures of the cationic Gemini surfactant with a conventional surfactant cetyl trimethylammonium bromide (CTAB) was investigated using the conductometric method at five different temperatures ranging from 303.15 to 323.15 K. CMC, micellar ionization degree (αm), counterion binding constant (g1), interaction parameter (β), and activity coefficients (f1M and f2M) of mixed systems were found out from data of conductivity at different mole fractions for all studied temperatures. Additionally, the effects of some inorganic salts with different concentrations on the surface properties of cationic Gemini surfactant were examined by surface tension measurements. Some surface properties of the pure cationic Gemini surfactant and mixed salts systems were calculated using the data of surface tension.

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“…:

Π_{CMC} = γ_{0} - γ_{CMC}

Section: Resultsmentioning

confidence: 99%

Investigation of Mixing Behavior of both a Conventional Surfactant and Different Inorganic Salts with a Cationic Gemini Surfactant in Aqueous Solution

Sarıkaya

Bilgen

Akbaş

2019

J Surfact & Detergents

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“…[36] Cholinium amino acid ILs were used to solubilize and stabilize paclitaxel, sterically and ionically, preventing the drug molecules from aggregating for 3 months. [37] Farooq et al [38] evidenced enhanced solubility through the formation of micelles by a surface active imidazolium chloride IL, with the antidepressant nortriptyline hydrochloride being trapped at the inner surface of the microstructures. Pal and Yadav [39] used a similar IL with a higher degree of substitution to solubilize anesthetics lidocaine hydrochloride and procaine hydrochloride, evidencing strong interactions between the drug molecules and the IL components.…”

Section: Solubilization Of Drugsmentioning

confidence: 99%

Recent Advances in Ionic Liquids in Biomedicine

2021

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The use of ionic liquids and deep eutectic solvents in biomedical applications has grown dramatically in recent years due to their unique properties and their inherent tunability. This review will introduce ionic liquids and deep eutectics and discuss their biomedical applications, namely solubilization of drugs, creation of active pharmaceutical ingredients, delivery of pharmaceuticals through biological barriers, stabilization of proteins and other nucleic acids, antibacterial agents, and development of new biosensors. Current challenges and future outlooks are discussed, including biocompatibility, the potential impact of the presence of impurities, and the importance of understanding the microscopic interactions in ionic liquids in order to design task-specific solvents.

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“…The micellization in gemini surfactants like other surface‐active molecules (Bhat et al, 2019; Farooq et al, 2017a; Farooq et al, 2018; Khan et al, 2017) occurs due to the hydrophobic interactions among their hydrocarbon chains and coulombic repulsions of hydrophilic head groups (Azum et al, 2016; Farooq et al, 2017b; Khan et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Surface, Micellar, and Aggregation Behavior of Non‐cytotoxic Imidazolium Gemini Surfactants

Shaheen

Mir

Arif

et al. 2020

J Surfact & Detergents

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The micellar, surface, and aggregation properties of biocompatible, imidazolium-based hydroxyl group-Br 2 , were studied. The surface parameters like maximum surface excess concentration at air/water interface (Γ max ), the minimum surface area occupied by surfactant molecules (A min ) and the related thermodynamic parameters such as, standard Gibbs free energy of micellization (ΔG 0 m ), standard free energy of adsorption (ΔG 0 ad ), and free energy of surface at equilibrium ðG s min ) were also determined from the surface parameters. The aggregation behavior has been elucidated from transmission electron microscopy (TEM) and dynamic light scattering (DLS) techniques which showed that these gemini surfactants have potential self-aggregation efficiency. Besides, some other physicochemical properties like foam stability, emulsifying power, and viscosity have been determined. The structural features of [C n Im-3OH-ImC n ]Br 2 enhance their surface-active properties. These features of gemini surfactants are of primary significance from pharmaceutical and biomedical viewpoints. The gemini surfactants may have great implications in drug formulations and delivery owing to their prominent aggregation and non-cytotoxic nature.

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Interaction of a Surface-Active Ionic Liquid with an Antidepressant Drug: Micellization and Spectroscopic Studies

Cited by 32 publications

References 54 publications

Investigation of Mixing Behavior of both a Conventional Surfactant and Different Inorganic Salts with a Cationic Gemini Surfactant in Aqueous Solution

Investigation of Mixing Behavior of both a Conventional Surfactant and Different Inorganic Salts with a Cationic Gemini Surfactant in Aqueous Solution

Recent Advances in Ionic Liquids in Biomedicine

Surface, Micellar, and Aggregation Behavior of Non‐cytotoxic Imidazolium Gemini Surfactants

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