Most applications related to bubble drag reduction (BDR) occur in contaminated environments where the presence of different surface active agents modify bubble coalescence and hence, affect flow drag. Although there have been studies on bubble drag modifications with salt/surfactant, the effects of systematic variation in salt/surfactant concentration on bubble dynamics and drag remain relatively unexplored. Driven by this motivation, in the present work, we experimentally investigate the effects of salt concentration on the bubble dynamics and drag modification in a fully developed horizontal turbulent channel flow for top wall bubble injection, over a wide range of salt concentrations (0< M <0.08, moles/liter), channel Reynolds number (22,500< Re <65,000), and injected bubble void fraction (0< α <0.16). The injected bubbles interact with the flow in the turbulent channel and as they move downstream reach an equilibrium state between the bubbly phase and the fully developed carrier phase that persists further downstream. The equilibrium state of the bubble dynamics is captured by high-speed visualizations and the corresponding drag is obtained from stream-wise pressure drop measurements within the channel. Increasing salt concentration levels is seen to lead to reduction in bubble coalescence and consequently in bubble size that modifies bubble deformability, migration, and distribution near the top wall, with the changes being dependent on the Re and α values. At low Re ≈ 22, 500, the addition of salt leads to a dramatic reduction in bubble sizes (∼ 100 microns)