Abstract:Type IA topoisomerases relax negatively supercoiled DNA by catalyzing the breaking and rejoining of DNA single‐strand coupled with DNA strand passage through the break. The proposed mechanism suggested that the torus‐shaped structure formed by domains D1‐D4 of the enzymes can adopt two possible conformations: “closed” and “open” with D3 in contact with D1 and proximity to D4 or D3 moving away from D1 and D4 to open up the toroid hole. However, the molecular basis of the opening‐closing of the toroid hole remai… Show more
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