Interaction effects of FTO rs9939609 polymorphism and lifestyle factors on obesity indices in early adolescence

Jiang, Yanrui; Mei, Hao; Lin, Qingmin; Wang, Jian; Liu, Shijian; Wang, Guanghai; Fan, Jian‐Gao

doi:10.1016/j.orcp.2019.06.004

Cited by 18 publications

(26 citation statements)

References 35 publications

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“…A large-scale meta-analysis targeting GWAS analysis of East Asian populations found that FTO SNPs rs17817449 have the most significant correlation with BMI in people of Chinese descent (Wen et al, 2012). In recent years, global studies have associated the rs9939609 variant with higher obesity risks in other populations (including Brazilian people, early adolescence in China, and adults in Shiraz, Iran) (Fonseca et al, 2019;Jiang et al, 2019;Mehrdad et al, 2020b). It is also associated with increased BMI and waist circumference (in Brazilian youths) (Reuter et al, 2016), adipose tissue distribution (in Italian people), and increased metabolic syndrome susceptibility (in Chinese populations) (Merra et al, 2020;Wang et al, 2020).…”

Section: Association Of Fto Snps With Obesitymentioning

confidence: 99%

FTO – A Common Genetic Basis for Obesity and Cancer

et al. 2020

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In recent years, the prevalence of obesity and cancer have been rising. Since this poses a serious threat to human health, the relationship between the two has attracted much attention. This study examined whether fat mass and obesity-associated ( FTO ) genes are linked, taking into account a Genome-wide Association Study (GWAS) that revealed multiple single nucleotide polymorphism sites (SNPs) of the FTO gene, indicating an association between obesity and cancer in different populations. FTO proteins have been proved to participate in adipogenesis and tumorigenesis with post-transcriptional regulation of downstream molecular expression or through the target of the mammalian target protein rapamycin (mTOR). FTO inhibitors have also been found to share anti-obesity and anti-cancer effects in vivo . In this review, we comprehensively discuss the correlation between obesity and cancer by measuring FTO gene polymorphism, as well as the molecular mechanism involved in these diseases, emphasizing FTO as the common genetic basis of obesity and cancer.

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Section: Association Of Fto Snps With Obesitymentioning

confidence: 99%

FTO – A Common Genetic Basis for Obesity and Cancer

et al. 2020

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“…These behaviors could be primary determinants of early obesity incidence 3,7 . Conversely, genetic predisposition to obesity is the a non‐modifiable risk factor in obesity development with a heritability ranging from 40% to 70% 8,9 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Previous studies have indicated that children and adolescents with a predisposed genetic risk for obesity could benefit from a healthy and active lifestyle 8,9 . Additionally, youth without genetic predisposition could become obese with poor lifestyle behaviors 8,9 . Within this context, adequate levels of physical activity could be important effect modifiers because of the dose‐response association with obesity prevalence 10,11 .…”

Section: Introductionmentioning

confidence: 99%

“…Among the genetic aspects of obesity, genetic polymorphisms have been previously associated with the early development of obesity, accelerating weight gain over childhood, including rs9939609 (FTO), rs6548238 (TMEM18), and rs16835198 (FNDC5) 8,9 . In adults, physical fitness attenuated the influence of genetic predisposition on obesity risk 13 .…”

Section: Introductionmentioning

confidence: 99%

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Physical fitness attenuates the genetic predisposition to obesity in children and adolescents

Todendi

Brand

Silveira

et al. 2020

Scandinavian Med Sci Sports

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Obesity is an important risk factor associated with non‐communicable cardiometabolic diseases. Previous studies have indicated that children and adolescents with a predisposed genetic risk for obesity could benefit from an active lifestyle, but there are no studies investigating whether physical fitness moderates the association of genetics and obesity. The aim of this study was to verify the moderating role of physical fitness in the relationship between genetic risk score (GRS) and body mass index (BMI) in children and adolescents. This cross‐sectional study was carried out with 1471 children and adolescents, aged between 6 and 17 years from Santa Cruz do Sul, Brazil. Weight and height were assessed to determine BMI. Physical fitness components (cardiorespiratory fitness [CRF], lower limb strength [LLS], upper limb strength, and abdominal strength) were evaluated. The GRS was based on previously associated obesity single‐nucleotide polymorphism rs9939609 (FTO), rs6548238 (TMEM18), and rs16835198 (FNDC5). Moderation analyses were tested using linear regression models, and the interactions were represented by physical fitness components X GRS (categorical variable). All analyses were adjusted for skin color/ethnicity, sex, and sexual maturation. Significant interactions for CRF (P = 0.041), LLS (P = 0.041), and abdominal strength (P = 0.046) X 5 and 6 risk alleles with BMI were found only in adolescents. In addition, there was evidence that fitness components attenuated the high genetic predisposition to high BMI. Physical fitness components are moderators in the relationship between GRS and BMI in adolescents. These findings highlight the need for interventions targeting to improve this aspect, which is an important health indicator in all ages.

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Breastfeeding moderates the relationship between fat mass and obesity‐associated gene rs9939609 and body mass index among adolescents

Kanders

Nilsson

Åslund

2021

Obesity Science & Practice

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Objective: Breastfeeding, which is important for early growth, is a possible moderator of genetic influence, such as the effect of the fat mass and obesityassociated gene (FTO) on body mass index (BMI). The aim of this study was to assess the moderating effect of breastfeeding duration on the relationship between FTO rs9939609 and BMI in a Caucasian sample. Methods: Adolescents born in 1997 and in 1999, who were living in the Swedish county Västmanland in 2012, were invited to participate in the Survey of Adolescent Life in Västmanland. The adolescents and their parents completed self-reported questionnaires in 2012, 2015, and 2018. Genotyping of rs9939609 T > A polymorphism was conducted from saliva DNA samples. Interaction effects of parental reported breastfeeding duration in months, including regions of significance, on the relationship between rs9939609 and BMI plus overweight were assessed.Results: Considering physical activity levels, parental reported breastfeeding duration was a moderator of the relationship between rs9939609 and BMI for the younger (regions of significance = <1.6 and >28.1 months) and older adolescents (region of significance = >19.9 months), but not for the young adults. Plots of the association between breastfeeding duration and BMI showed higher BMI for AA with short breastfeeding, but lower BMI with longer breastfeeding than AT and TT.Longer breastfeeding lowered the odds for overweight among the younger adolescents, especially among AA individuals. Conclusion:Rs9939609 AA individuals were more susceptible than AT and TT individuals to both short and long breastfeeding durations, which is consistent with the differential susceptibility hypothesis. FTO rs9939609 AA might be a plasticityThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Interaction effects of FTO rs9939609 polymorphism and lifestyle factors on obesity indices in early adolescence

Cited by 18 publications

References 35 publications

FTO – A Common Genetic Basis for Obesity and Cancer

FTO – A Common Genetic Basis for Obesity and Cancer

Physical fitness attenuates the genetic predisposition to obesity in children and adolescents

Breastfeeding moderates the relationship between fat mass and obesity‐associated gene rs9939609 and body mass index among adolescents

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