Interaction dynamics of spatially separated cavitation bubbles in water

Tinne, N.; Schumacher, Silvia; Nuzzo, Valeria; Arnold, Cord L.; Lubatschowski, Holger; Ripken, Tammo

doi:10.1117/1.3526366

Cited by 27 publications

(30 citation statements)

References 46 publications

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“…With various transversal focal distances but without temporal separation, this was presented in a former publication 29 showing interesting phenomena, such as the build-up of jets. A thorough coverage of more complex combinations of spatial and temporal pulse-to-pulse separations is part of further experimental studies.…”

Section: Discussionmentioning

confidence: 99%

“…29 Here, the temporal overlap of pulses and bubbles leads to a reduced effectiveness in terms of the used fluence for the cutting process. The energy of laser pulses impinging persistent gas bubbles due to the previous pulse (overlap parameter η t > 1) will be partly lost for the cutting process itself.…”

Section: Discussionmentioning

confidence: 99%

“…Here, it has to be noticed that the measurements with the "μJewel" laser system were performed with a water-immersion microscope objective of NA ¼ 0.5; the details of this previous setup can be found in Ref. 28,29. In more solid sample media, that means beside water, a remaining mechanical damage can be induced at the focal spot.…”

Section: Focusing Of Temporally Separated Fs-lasermentioning

confidence: 99%

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Effects of cavitation bubble interaction with temporally separated fs-laser pulses

et al. 2014

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Abstract. We present a time-resolved photographic analysis of the pulse-to-pulse interaction. In particular, we studied the influence of the cavitation bubble induced by a fs-pulse on the optical focusing of the consecutive pulse and its cavitation bubble dynamics in dependence on temporal pulse separation in water. As a first result, by decreasing the temporal separation of laser pulses, there is a diminishment of the laser-induced optical breakdown (LIOB) efficiency in terms of energy conversion, caused by disturbed focusing into persisting gas bubbles at the focal volume. A LIOB at the focal spot is finally suppressed by impinging the expanding or collapsing cavitation bubble of the preceding pulse. These results could be additionally confirmed in porcine gelatin solution with various concentrations. Hence, the interaction between the laser and transparent ophthalmic tissue may be accompanied by a raised central laser energy transmission, which could be observed in case of a temporal pulse overlap. In conclusion, our experimental results are of particular importance for the optimization of the prospective ophthalmic surgical process with future generation fs-lasers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Focusing Of Temporally Separated Fs-lasermentioning

confidence: 99%

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Effects of cavitation bubble interaction with temporally separated fs-laser pulses

et al. 2014

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“…The initial energy in the pulse is absorbed by the laser-produced plasma, which converts its energy to light, heat, and mechanical energy; the latter two are found in the shock wave and the bubble [7] . The cavitation bubble grows to its maximum size then it collapses to start it over again.…”

Section: Introductionmentioning

confidence: 99%

Laser-induced cavitation phenomenon studied using three different optically-based approaches – An initial overview of results

Devia-Cruz

Camacho‐López

Evans

et al. 2012

Photonics &Amp; Lasers in Medicine

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This report presents a study of shock wave and cavitation bubble dynamics induced by nanosecond laser pulses in pressurized water. Three methods were used to obtain data from the irradiated sample: (1) pump-probe laser flash shadowgraphy, (2) pressure wave sensing by means of a fiber optic interferometer hydrophone, and (3) a novel technique based on the modulation of spatial transmittance by the cavitation bubble. The medium used in these experiments was distilled water in a chamber under different pressure conditions which included values found in human intraocular liquid. It could be shown that while external pressure does not affect either the shock wave propagation or the initial bubble growth rate, it does affect the first collapse time of the bubble and its maximum diameter.Keywords: bubble; shock wave; microsurgery; pressure; intraocular.Zusammenfassung : Die vorliegende Arbeit untersucht die Dynamik von Schockwellen und Kavitationsblasen, die mittels Nanosekunden-Laserpulsen in unter Druck gesetztem Wasser erzeugt wurden. Dabei wurden drei unterschiedliche Methoden verwendet: (1) Laserflash-Verfahren, (2) Druckwellenmessung mittels faseroptischem Interferometer und (3) eine neuartige Technik basierend auf der Modulation der r ä umlichen Transmission durch die Kavitationsblase. Die Untersuchungen wurden an destilliertem Wasser unter unterschiedlichen Dr ü cken -u.a. auch physiologische Werte, wie sie intraokular vorkommen -vorgenommen, die mittels einer speziellen Druckkammer erzeugt wurden. Es konnte gezeigt werden, dass weder die Ausbreitung der Schockwelle noch das anf ä ngliche Blasenwachstum durch den ä u ß eren Druck beeinflusst wird, die Kollapszeit der Blase und ihr maximaler Durchmesser jedoch sehr wohl.Schl ü sselw ö rter: Blase; Schockwelle; Mikrochirurgie; Druck; intraokular.

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“…Most studies are based on the bubble-bubble interaction between two bubbles, where asymmetry, deformation and attraction are reported 487 . Interactions between bubbles can be experienced up to a distance of 10 radii 487,488 . It is not likely that the vaporization process observed here is influenced by these interactions.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound contrast agents: bubbles drops and particles

Lajoinie¹

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The research described in this thesis is part of the research program NanoNextNL, a micro and nanotechnology consortium of the Government of the Netherlands and 130 partners. This thesis was carried out at the Physics of Fluids group of the Faculty of Science and Technology of the University of Twente. Cover design:As a representation of a crucial goal of this work, the cover depicts a confocal microscopy image showing cells selectively porated by loaded microbubbles upon ultrasound exposure. The porated cells take up a blue fluorescent probe. By Ine Lentacker, Ine De Cock and Guillaume Lajoinie. Guide through the thesisIn this thesis, we investigate different types of innovative agents, designed for biomedical use in a context of molecular imaging. In Chapter 1, we review the agents that arouse the interest of the scientific community, most of them at the research stage of development, together with the experimental methods that can be used to study their interaction with cells. Such in vitro investigations are necessary to test on short scales the impact of the various agents on biological structures.We separate the agents in three main categories. The first group consists of stabilized microbubbles, usually by means of phospholipids that fill up the interfacial area between the gas core and the surrounding liquid (water). Such bubbles are clinically used for 40 years as contrast agents for ultrasound owing to their unique resonance behavior. When irradiated with an ultrasound pulse, a bubble experiences volumetric oscillations, that reemit an ultrasound wave back to the transducer. This process makes them unchallenged ultrasound scatterers. The role of these stable microbubbles in new biomedical research directions is discussed in Chapters 2 to 9.Phospholipid coatings were developed in the last decade to do much more than just prevent bubble dissolution. They are now a crucial tool to enrich the microbubbles with specific markers or drug payloads. In Chapter 2, we investigate the behavior of this coating when the microbubbles are subjected to an ultrasound field. We show that the coating is shed away from the microbubble, which is of major interest for molecular imaging combined with drug delivery using microbubbles. We pursue the idea in Chapter 3 where we investigate how a bubble payload, here liposomes labeled with a fluorescent dye, is released under ultrasound exposure. In Chapter 4, we link these direct observations of shedding of the previous Chapters to the subsequent dissolution of the microbubbles, no longer protected by a phospholipid shell. This dissolution, visible in the ultrasound scatter spectrum can be used to remotely quantify the effect of the microbubbles. In support of these observations, we dedicate the next Chapter (Chapter 5) to physically understand the mechanisms underlying the behavior of the phospholipid coating. The application of these findings in practice requires the production a sufficiently high production rate and with great control of such microbubbles. In Chapter 6, we th...

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Interaction dynamics of spatially separated cavitation bubbles in water

Cited by 27 publications

References 46 publications

Effects of cavitation bubble interaction with temporally separated fs-laser pulses

Effects of cavitation bubble interaction with temporally separated fs-laser pulses

Laser-induced cavitation phenomenon studied using three different optically-based approaches – An initial overview of results

Ultrasound contrast agents: bubbles drops and particles

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