Interaction Between XRCC1 Gene Polymorphisms and Obesity on Susceptibility to Papillary Thyroid Cancer in Chinese Han Population

Abstract

Background/Aims: To investigate the association of several single nucleotide polymorphisms (SNPs) within XRCC gene and additional gene- environment interaction with papillary thyroid cancer (PTC) risk. Methods: Testing for Hardy-Weinberg equilibrium in controls was conducted using SNPstats (online software: http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among 5 SNPs within XRCC gene and obesity. Results: Logistic regression analysis showed that the C allele of rs861539 and T allele of rs1799782 were associated with increased PTC risk Adjusted ORs (95%CI) were 1.65 (1.23-2.12) and 1.61 (1.20-2.04). However There was no relation of rs25489 Rs25487 and rs13181 with PTC. The cross-validation consistency and the testing accuracy for each of the models were determined by GMDR analysis. One two-locus model (rs1799782 and obesity) had a testing accuracy of 62.11% Which was significant at the p < 0.01 level. The D’ value between rs1799782 and rs13181 within ERCC1 gene was more than 0.75 (0.825). So haplotype analysis was just conducted for rs1799782 and rs13181 using the SHEsis online haplotype analysis software. In all samples The haplotype C- A was observed most frequently in two groups With 49.46% and 55.79% in the PTC patients and controls Respectively. The results also indicated that haplotype T- C was significantly associated with increased PTC risk. Conclusion: The C allele of rs861539 and T allele of rs1799782 Interaction between rs1799782 and obesity and haplotype T- C were all associated with increased PTC risk.

Haplotypes of single cancer driver genes and their local ancestry in a highly admixed long-lived population of Northeast Brazil

“…, 2018 ; Smolarz and Romanowicz, 2018 ; Qiao et al , 2018 ; Minina et al , 2019 ; Liu et al , 2019 ; Aboul Enein et al , 2020 ; Cai et al , 2020 ; Smolarz et al , 2019 ) rs25486 ( Roberts et al , 2011 ) rs1799782 ( Alimu et al , 2018 ; Bashir et al. , 2018 ; Li et al , 2018 ; Zhu et al. , 2018 ; Cai et al , 2020 ) rs762507 ( Sacerdote et al , 2013 ) Bladder cancer survival TCGC (28.0%) 1 4.67 0.036 0.67-1.0 CTGT (27.6%) 1 15.43 0.152 0.89-1.0 CTAC (8.2%) 1 4.99 0.039 0.69-1.0 CCGC (2.1%) 1 16.28 0.164 0.9-1.0 ERCC2 TG (78.2%) rs13181 rs1052555 1 59.91 0.622 0.96-1.0 rs13181 ( Dai et al , 2019b ...…”

GA genotype of the Arg280His polymorphism on the XRCC1 gene: Genetic susceptibility genotype in differentiated thyroid carcinomas?

“…A report from the USA has reported that the AA genotype in XRCC1 Arg399Gln polymorphism decreases the risk of PTC [ 11 ], but this association was not demonstrated in other studies [ 13 , 14 , 17 ]. In Caucasians, it has been reported that the AA genotype in XRCC1 Arg399Gln polymorphism causes a significant decrease in the risk of DTC [ 2 ].…”

Association Between the XRCC1, GSTM1, and GSTT1 Polymorphisms in Model of Thyroid Cancer: A Meta-Analysis

“…1. ▶ table 1 summarizes the key characteristics of the 12 studies [27][28][29][30][31][32][33][34][35][36][37][38] included in this analysis. The sample sizes of these studies ranged from 211 to 1124 participants.…”