Interaction between vitamin B6 and source of selenium on the response of the selenium-dependent glutathione peroxidase system to oxidative stress induced by oestrus in pubertal pig

Dalto, Danyel Bueno; Roy, Mélanie; Audet, Isabelle; Palin, Marie‐France; Guay, Frédéric; Lapointe, Jérôme; Matte, J. J.

doi:10.1016/j.jtemb.2015.05.002

Cited by 35 publications

(42 citation statements)

References 49 publications

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“…The link between oxidative stress and reproductive performance has been well established, with severe oxidative stress rapidly and effectively impairing ovarian development in pigs [6]. Notably, there is an increase in the defective cohort of oocytes in cycling gilts during feeding at high nutritional levels compared to those fed at maintenance levels [7].…”

Section: Introductionmentioning

confidence: 99%

Effect of High Fat Dietary Intake during Maternal Gestation on Offspring Ovarian Health in a Pig Model

Che

Yang

et al. 2016

Nutrients

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Excessive fat intake is a global health concern as women of childbearing age increasingly ingest a high fat diet. We therefore determined the association of a maternal high fat diet in pregnancy with offspring ovarian health during the gestation and postnatal female offspring in pig a model. Thirty-two Yorkshire gilts with similar bodyweights mated at the third estrus were randomly assigned to two nutrition levels of either a control (CON, crude fat: 7.27%) or a high fat diet (HFD, crude fat: 11.78%). Ovary samples were collected during the fetal (Day 55 (g55) and Day 90 of gestation (g90)) and offspring (prepuberty Day 160 (d160) and age at puberty) period to detect ovary development, antioxidant status and apoptosis cells. Maternal HFD did not influence notch signaling gene expression, which regulates primordial follicle formation and transformation, and ovarian histological effect at g55 and g90. However, maternal HFD reduced the numbers of large follicles at d160 and small follicle numbers upon puberty compared to CON in offspring. The results also revealed that the antioxidant index of total antioxidative capability (T-AOC), cytoplasmic copper/zinc superoxide dismutase (CuZn-SOD), glutathione peroxidase (GPx) activities and mRNA expression were higher in the CON than the HFD at g90 and d160, whereas, malondialdehyde (MDA) concentration was decreased in the CON. Maternal HFD increased the inhibitor of the apoptosis-related gene of B-cell lymphoma-2 (bcl2) mRNA expression at g90 and d160, whereas, pro-apoptotic-related gene bcl-2 assaciated X protein (bax) was reduced. These data show that the maternal high fat diet does not delay fetal ovarian development, but it changes ovarian health by the induction of oxidative stress and accelerating cell apoptosis in offspring.

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Section: Introductionmentioning

confidence: 99%

Effect of High Fat Dietary Intake during Maternal Gestation on Offspring Ovarian Health in a Pig Model

Che

Yang

et al. 2016

Nutrients

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“…Considering that mammals metabolize seleno-amino acids in the same way as their sulfur counterparts [37], recent studies by this laboratory on the effects of selenium (Se) sources and levels combined or not with B 6 provided indirect support to this effect of ROS. Dalto et al [38] reported that, under the oxidative stress of ovulation, the gene expression of GPX1, 3, and 4 in the livers (Table 1) and kidneys (Table 2) of Se-supplemented animals were higher than in the control Se-unsupplemented group, and animals supplemented with organic Se plus B 6 had the highest gene expression of GPX1 and selenocysteine lyase (SCLY), indicating that the transsulfuration pathway was stimulated. In contrast, Dalto et al [39] observed, under basal oxidative stress conditions, no differential expression for the same genes (Table 1 and Table 2).…”

Section: Transmethylation Vs Transsulfurationmentioning

confidence: 99%

Pyridoxine (Vitamin B6) and the Glutathione Peroxidase System; a Link between One-Carbon Metabolism and Antioxidation

Dalto

Matte

2017

Nutrients

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Vitamin B6 (B6) has a central role in the metabolism of amino acids, which includes important interactions with endogenous redox reactions through its effects on the glutathione peroxidase (GPX) system. In fact, B6-dependent enzymes catalyse most reactions of the transsulfuration pathway, driving homocysteine to cysteine and further into GPX proteins. Considering that mammals metabolize sulfur- and seleno-amino acids similarly, B6 plays an important role in the fate of sulfur-homocysteine and its seleno counterpart between transsulfuration and one-carbon metabolism, especially under oxidative stress conditions. This is particularly important in reproduction because ovarian metabolism may generate an excess of reactive oxygen species (ROS) during the peri-estrus period, which may impair ovulatory functions and early embryo development. Later in gestation, placentation raises embryo oxygen tension and may induce a higher expression of ROS markers and eventually embryo losses. Interestingly, the metabolic accumulation of ROS up-regulates the flow of one-carbon units to transsulfuration and down-regulates remethylation. However, in embryos, the transsulfuration pathway is not functional, making the understanding of the interplay between these two pathways particularly crucial. In this review, the importance of the maternal metabolic status of B6 for the flow of one-carbon units towards both maternal and embryonic GPX systems is discussed. Additionally, B6 effects on GPX activity and gene expression in dams, as well as embryo development, are presented in a pig model under different oxidative stress conditions.

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“…The knot linking oxidative stress patterns to intense reproductive performances reveals that severe oxidative stress highly impairs ovarian development in pigs [5]. The immune functionality of the foetus is readily affected due to inadequate supply of antioxidants in pigs as they share biological similarities to humans.…”

Section: Journal Of Clinical Nutrition and Dietetics Issn 2472-1921mentioning

confidence: 99%

Review: Dietary and Weight Factors during and after Maternal Preconception

Samuel¹

2017

J Clin Nutr Diet

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Pregnancy is a brief period of the entire human life. It is an essential and crucial time of human growth and development. Nutrient requirements at this stage are exceptionally required to maintain steady growth of the mother and child before preconception and during conception. However, deficiencies in such nutrients may result in complications to the African mother and also predisposes the foetus/child to potential risk elements like T2D, respiratory disorders amongst other health implications. It would be plausible reproducing healthy offspring and doing so with ease and still retaining vigour at the end of each pregnancy, wouldn't it? Mothers around the world (especially African mothers) are further enlightened in this study about the dietary necessities during and after child birth (that is at every stage of pregnancy). This study updates women of all works of life, all ages as well as ethnicity, on their weight acquisition or losses, and that of the foetus (their bouncing babies). This study generally compromises the relationship between nutritional diets and their substantial effects on the mother and the foetus, and how this will in turn have benefiting effects on the child's future healthiness for a very long time. This study addressed some arguments surrounding maternal preconception and dietary nutrients using materials from experimental studies of some hosts of research analysts and scientists. Education is the key to proffering sustainable health for our intending mothers and pregnant mothers. In this study I examined relevant studies and arguments to better buttress the need for this study and found out that indeed nutrients are the key to healthy conception. This study concludes on the note that women should be more concerned about what they eat at all times and especially during pregnancy. Their weight gain is also important as it could be the best way to monitor and control pregnancy complications like the gestational diabetes mellitus which could lead to other disease complications.

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Interaction between vitamin B6 and source of selenium on the response of the selenium-dependent glutathione peroxidase system to oxidative stress induced by oestrus in pubertal pig

Cited by 35 publications

References 49 publications

Effect of High Fat Dietary Intake during Maternal Gestation on Offspring Ovarian Health in a Pig Model

Effect of High Fat Dietary Intake during Maternal Gestation on Offspring Ovarian Health in a Pig Model

Pyridoxine (Vitamin B6) and the Glutathione Peroxidase System; a Link between One-Carbon Metabolism and Antioxidation

Review: Dietary and Weight Factors during and after Maternal Preconception

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