Interaction between VGDF exposure and antioxidant genes on COPD in UK Biobank

Interaction of Smoking and Social Status on the Risk of Respiratory Outcomes in a Swedish Adult Population: A Nordic Epilung Study

“…The observed higher probability of respiratory diseases among smokers in lower socioeconomic groups compared to higher socioeconomic groups is consistent with previous findings showing higher risk of COPD, chronic bronchitis among groups of combined exposure to occupational dust, fumes and vapors and smoking.De Meer et al [28] similarly found that smokers who were exposed to mineral dust at work were at higher risk of chronic bronchitis and lower FEV 1 /FCV ratios than the expected risk of smoking and mineral dust separately [32,33]. Van der Plaat et al [34] in turn, found an interaction between vapor, gas dust and fumes exposure and smoking on the risk of COPD [34]. Further, despite, using different measures of respiratory impairment, Hisinger-Mölkänen et al [35] observed that odds of chronic rhinitis, nasal symptoms and runny nose were the highest among the group with combined exposure to active or Fig.…”

ERS International Congress 2020: highlights from the Epidemiology and Environment Assembly

“…Finally, the last presenter attempted to assess the interaction between the environment and genetics using data from the large UK biobank. This study, presented by Diana van der Plaat, identified two rare genetic variants in the antioxidant genes GSTP1 and NOS1 that increased the risk of COPD by 19% and 30%, respectively, when subjects were also exposed to occupational exposure such as vapours, gases, dusts and fumes (VGDF) [ 18 ]. Interestingly, this interaction effect was more apparent in never-smokers, whereas the effect of VGDF exposure without taking the interaction into account was only seen in smokers.…”