Interaction between vanilloid and glutamate receptors in the central modulation of nociception

Palazzo, Enza; Novellis, Vito de; Marabese, Ida; Cuomo, Dario; Rossi, Francesca; Berrino, Liberato; Rossi, Francesco; Maione, Sabatino

doi:10.1016/s0014-2999(02)01367-5

Cited by 127 publications

(117 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A c c e p t e d M a n u s c r i p t 6 PAG microinjection of capsaicin increased the latency of the nociceptive reaction (Starowicz et al, 2007b) according to what has been observed previously into the DL subregion of PAG (Palazzo et al, 2002). Conversely, the selective TRPV1 receptor antagonist 5'-iodo-resiniferatoxin (I-RTX) facilitates nociceptive responses and, at a per se inactive dose, abolishes capsaicin-mediated antinociception, hence suggesting that the effect of capsaicin was mediated by TRPV1 receptors.…”

Section: The Role Of Trpv1 Receptors In Periaqueductal Greysupporting

confidence: 64%

“…Capsaicin (6 (Palazzo et al, 2002). McGaraughty et al, (2003) reported that capsaicin (10 nmol/rat) injected into the DL PAG decreases the latency of nociceptive behavioural responses, and showed that this compound induced hyperalgesia followed by analgesia; the latter possibly due to TRPV1 receptor desensitisation.…”

Section: The Role Of Trpv1 Receptors In Periaqueductal Greymentioning

confidence: 99%

“…Increasing evidence demonstrates the presence of TRPV1 receptors throughout the periaqueductal gray (PAG) Maione et al, 2007;McGaraughty et al, 2003;Starowicz et al, 2007). Stimulation of TRPV1 receptors in the PAG has been proven to inhibit pain by either acting on the downstream rostral ventromedial (RVM) neurons that mediate analgesia or by desensitizing the activity of other neurons involved in inducing hyperalgesia (McGaraughty et al, 2003;Palazzo et al, 2002;Starowicz et al, 2007b). In this review we highlight studies that report supraspinal TRPV1 receptor involvement in pain modulation with particular emphasis on the descending antinociceptive pathway areas such as the PAG and RVM.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of TRPV1 receptors in descending modulation of pain

Palazzo

Rossi

Maione

2008

Molecular and Cellular Endocrinology

Self Cite

View full text Add to dashboard Cite

Transient receptor potential vanilloid type 1 (TRPV1) receptor is a ligand-gated non selective cation channel activated by heat (>43°), low pH and endogenous lipid molecules such as anandamide, Narachydonoyl-dopamine, N-acyl-dopamines and products of lipoxygenases (12-and 15-(S)-HPETE) termed endovanilloids. Apart from peripheral primary afferent neurons and dorsal root ganglia, TRPV1 receptor is expressed throughout the brain. Recent evidence show that TRPV1 receptor stimulation by endocannabinoids or by capsaicin within the periaqueductal grey (PAG) leads to analgesia and this effect is associated with glutamate increase and the activation of OFF cell population in the rostral ventromedial medulla (RVM). Activation of the antinociceptive descending pathway via TPRV1 receptor stimulation in the PAG may be a novel strategy for producing analgesia. This review will summarize the more recent insights into the role of TRPV1 receptor within the antinociceptive descending pathway and its possible exploitation as a target for novel pain-killer agents.

show abstract

Section: The Role Of Trpv1 Receptors In Periaqueductal Greysupporting

confidence: 64%

Section: The Role Of Trpv1 Receptors In Periaqueductal Greymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of TRPV1 receptors in descending modulation of pain

Palazzo

Rossi

Maione

2008

Molecular and Cellular Endocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

“…PAG-mediated antinociception involves the recruitment of pain-modulating RVM neurons via the descending pain pathway (Bajic and Proudfit, 1999). Capsaicin, when injected into the dorsolateral periaqueductal grey (DLPAG), increased the latency of nociceptive responding to noxious heat, indicating that stimulation of TRPV1 within the descending inhibitory pain pathway can cause antinociception (Palazzo et al, 2002). Microinjection of capsaicin into the ventrolateral periaqueductal grey (VLPAG ) increased the threshold of thermal pain sensitivity in rats (Starowicz et al, 2007).…”

Section: Acute Painmentioning

confidence: 99%

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

Madasu

Okine

Olango

et al. 2016

Pharmacological Research

View full text Add to dashboard Cite

“…The earliest evidence for the presence of TRPV1 receptor in the PAG came from the observation that intra-PAG microinjections of capsaicin increased the latency of NR in a significant and dose-dependent fashion in the plantar test [71]. This effect was prevented by capsazepine, a selective TRPV1 antagonist.…”

Section: Functional Interaction Between Cannabi-noid and Metabotropicmentioning

confidence: 99%

Metabotropic Glutamate and Cannabinoid Receptor Crosstalk in Periaqueductal Grey Pain Processing

Palazzos

Novellis²,

Marabese³

et al. 2006

View full text Add to dashboard Cite

Metabotropic glutamate (mGlu) and cannabinoid receptors are G-protein coupled receptors which have shown synaptic co-operation through small lipid messengers in the central nervous system (CNS). A functional interaction between these two receptor families could have a relevant potential in the treatment of CNS disorders, including chronic pain. Indeed, both mGlu and cannabinoid receptors play a crucial role in the neurobiology of pain and their simultaneous manipulation could lead to novel strategies in pain management. In particular, as both mGlu and cannabinoid receptors have been found in the periaqueductal gray (PAG), a crucial station in the pain modulatory system, these receptors could be a substrate for producing analgesia at this level. In this review we aim to briefly illustrate the role of mGlu and cannabinoid receptors in controlling nociceptive processes, some points of convergence, and their functional interaction in pain processing. Further insights into this functional linkage between the mGlu and cannabinoid receptors could pave the way to a new strategy for pain relief, such as a drug cocktail acting on cannabinoid/metabotropic glutamate receptors.Key Words: Periaqueductal grey, metabotropic glutamate receptors; cannabinoid receptors, pain. METABOTROPIC GLUTAMATE RECEPTORS AND PAINMetabotropic glutamate (mGlu) receptors play an important role in the modulation of nociceptive processing and central sensitisation associated with persistent and chronic pain at several levels in the CNS [29,42,67,68].Several studies have shown that mGlu receptors modulate nociception from peripheral terminals [5,10,67,98,104]. This may stimulate the search for peripherally active mGlu receptor ligands, which are devoid of central adverse effects [30]. A role for mGlu receptors in spinal nociceptive processing has been reported, with particular emphasis on group I mGlu receptors [13,20,69,70,100,101,102,103]. Stimulation of group I mGlu receptors at spinal level generally produces pro-nociceptive effects [31,100], although functional differences between mGlu 1 and mGlu 5 receptors in modulating pain are recently emerging at the same rate as new selective mGlu receptor ligands are developed [69,90,101]. Spinal group I mGlu receptors also play an important role in nociceptive hypersensitivity associated with inflammation [8,69,101]. Intrathecal application of group II and group III agonists inhibit nociceptive responses [20,70,91], which may reflect the inhibition of glutamate release from nerve endings. Upregulation of mGlu 3 mRNA in the spinal cord following hind paw inflammation has also been reported [6]. A role for supraspinal mGlu receptors in the modulation of pain is also emerging, mGlu receptors modulate nociceptive responses at the level of ventrobasal thalamus [83][84][85], dorsal raphe [72] and amygdala [32,33,48]. This review will *Address correspondence to these authors at Department of Experimental Medicine, Section of Pharmacology "L. Donatelli"-Faculty of Medicine and Surgery, Second Universi...

show abstract

Interaction between vanilloid and glutamate receptors in the central modulation of nociception

Cited by 127 publications

References 43 publications

Role of TRPV1 receptors in descending modulation of pain

Role of TRPV1 receptors in descending modulation of pain

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

Metabotropic Glutamate and Cannabinoid Receptor Crosstalk in Periaqueductal Grey Pain Processing

Contact Info

Product

Resources

About