Interaction between tylosin and bentonite clay from a pharmacokinetic perspective

Devreese, Mathias; Osselaere, Ann; Goossens, Joline; Vandenbroucke, Virginie; Baere, Siegrid De; Backer, Patrick De; Croubels, Siska

doi:10.1016/j.tvjl.2012.05.016

Cited by 20 publications

(13 citation statements)

References 8 publications

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“…Tylosin is widely used as antimicrobial agent in China and administered through pareteral or oral route. The Pharmacokinetics study of tylosin has been described in a variety of animals including hens [ 14 ], broiler chickens [ 15 ], goats [ 16 ], cows [ 17 ] and dog [ 18 ]. However, there are limited data available on the Pharmacokinetics/pharmacodynamics model of tylosin in pigs [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs

Huang

Zhang

et al. 2018

BMC Vet Res

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BackgroundThe aim of this study was to optimize the dosage regimen of tylosin against S.suis in Pigs using pharmacokinetic-pharmacodynamic (PK-PD) modeling. The antibacterial activity of tylosin against S.suis CVCC606 was investigated in Mueller Hinton (MH) broth and serum. The objectives of this investigation were to study the PD data of tylosin against S.suis CVCC606 and the PK data of tylosin in healthy and diseased model of pigs and formulate a rational dosage regimen for the treatment of pig streptococcosis.ResultsThe minimum inhibitory concentrations (MIC) were 0.25 μg/mL, and the minimal bactericidal concentrations (MBC) were 1 μg/mL in MH broth and serum. The killing curve showed time-dependent activity and weak concentration-dependent antibacterial activity. A pig pneumoniae model of S. suis infection was built by inoculating subcutaneously with S. suis CVCC606. Tylosin was (10 mg/kg b.w) administered intramuscularly (IM) to the healthy and S.suis infected pigs, The pharmacokinetic properties, including area under the curve(AUC), peak concentration (Cmax) and time to reach Cmax (Tmax), were determined in plasma using UV-HPLC method. The AUC, Cmax and Tmax in plasma of healthy and infected pigs were 10.80 ± 2.20 and 10.30 ± 3.46 μg.h/mL, 2.06 ± 0.43 and 2.37 ± 0.38 μg/mL, 1.95 ± 0.22 and 1.58 ± 0.49 h, respectively.ConclusionsThe in vivo PK and in vitro PD data were integrated to determine the surrogate marker of antibacterial activity, Cmax/MIC, AUC/MIC and T>MICwere 8.90, 43.21, 8.86 for healthy pigs, and 9.76, 41.18, 7.56 for infected pigs, respectively. Ex vivo AUC/MIC data were integrated with ex vivo bacterial count to calculate the values for bacteriostatic and bactericidal action, which were 10.67 h and 49.66 h for healthy pigs, 11.73 h and 43.03 h for pigs infected with S.suis. A dosage regimen of 5.32–19.50 mg/kg b.w. every 24 h should be sufficient for tylosin against S.suis.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs

Huang

Zhang

et al. 2018

BMC Vet Res

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“…Only a few literature reports have investigated the adsorption of veterinary medicinal products to clays. Interactions were reported for the macrolide antibiotics tilmicosin (TIL) 13 and tylosin (TYL) 14,15 and for the coccidiostats monensin (MON) and salinomycin (SAL). 16 Schryock et al 13 studied the effectiveness of TIL for the prevention of airsacculitis in broiler chickens infected with Mycoplasma gallisepticum.…”

Section: ■ Introductionmentioning

confidence: 99%

In Vitro Adsorption and in Vivo Pharmacokinetic Interaction between Doxycycline and Frequently Used Mycotoxin Binders in Broiler Chickens

Mil

Devreese

Broekaert

et al. 2015

J. Agric. Food Chem.

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Mycotoxin binders are readily mixed in feeds to prevent uptake of mycotoxins by the animal. Concerns were raised for nonspecific binding with orally administered veterinary drugs by the European Food Safety Authority in 2010. This paper describes the screening for in vitro adsorption of doxycycline-a broad-spectrum tetracycline antibiotic-to six different binders that were able to bind >75% of the doxycycline. Next, an in vivo pharmacokinetic interaction study of doxycycline with two of the binders, which demonstrated significant in vitro binding, was performed in broiler chickens using an oral bolus model. It was shown that two montmorillonite-based binders were able to lower the area under the plasma concentration-time curve of doxycycline by >60% compared to the control group. These results may indicate a possible risk for reduced efficacy of doxycycline when used concomitantly with montmorillonite-based mycotoxin binders.

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“…Nossos resultados de caracterização corroboraram com os dados de Devreese et al, (2012) e Sampatakakis et al (2013), que também demonstraram a presença de picos de montmorillonita (M), caulinita (C), muscovita (M c ) e quartzo(Q) (Figura 1). Figura 1.…”

Section: Resultsunclassified

Partículas Argilominerais Não Influenciam a Viabilidade Das Células-Tronco Da Crista Neural

Nones¹,

Riella²,

Kuhnen³

et al. 2015

Anais Do XX Congresso Brasileiro De Engenharia Química

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RESUMO -Partículas argilominerais apresentam inúmeras aplicações na indústria farmacêutica. Apesar de serem biotecnologicamente empregadas, seus efeitos sobre células-tronco da crista neural (CN) permanecem desconhecidos. Considerando estes aspectos, o objetivo deste trabalho foi caracterizar quimicamente partículas argilominerais (bentonita) extraídas da região Sul de Santa Catarina, assim como verificar sua influência sobre a viabilidade e sobrevivência das células-tronco da CN. Para tal, essas partículas argilominerais foram caracterizadas por difração de raios-X e ensaios físico-químicos. A viabilidade e morte das células foram determinadas por MTT e análise dos núcleos picnóticos, respectivamente. Nossos resultados demonstraram que partículas argilominerais (bentonita 0,6 mg/mL) não influenciam a viabilidade e a sobrevivência celular. Considerando as propriedades farmacológicas da bentonita, outros estudos deverão ser realizados com o intuito de avaliarmos seus efeitos em terapias envolvendo células-tronco.

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Interaction between tylosin and bentonite clay from a pharmacokinetic perspective

Cited by 20 publications

References 8 publications

Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs

Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs

In Vitro Adsorption and in Vivo Pharmacokinetic Interaction between Doxycycline and Frequently Used Mycotoxin Binders in Broiler Chickens

Partículas Argilominerais Não Influenciam a Viabilidade Das Células-Tronco Da Crista Neural

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