Interaction between tumour necrosis factor-α gene polymorphisms and substance use on risk of betel quid-related oral and pharyngeal squamous cell carcinoma in Taiwan

Yang, Chung‐Yi; Hou, Yu‐Yi; Chiu, Yi-Ten; Chen, Hung-Chih; Chu, Sau-Tung; Chi, Chao-Chuan; Hsiao, Michael; Lee, Chien-Yiing; Hsieh, Christina Jen-Chia; Lin, Yu‐Chen; Hsieh, Yao-Dung; Ger, Luo‐Ping

doi:10.1016/j.archoralbio.2011.03.009

Cited by 22 publications

(26 citation statements)

References 33 publications

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“…Finally, after the full text screening, six studies were excluded by followed reasons: one study was not referred gene TNF-α (Hung et al, 2012), one study was not case-control designed DOI:http://dx.doi.org/10.7314/APJCP.2013.14.12.7243 Tumor Necrosis Factor-α (Li et al, 2001), three studies were not supplied the data we needed (Matthias et al, 1998;de Lius et al, 2007;Wenghoefer et al, 2009), and one study was using the overlapped data (Vairaktaris et al, 2008). Among the included eight case-control studies (Chiu et al, 2001;Chen et al, 2005;Liu et al, 2005;Gupta et al, 2008;Yapijakis et al, 2009;Kietthubthew et al, 2010;Yang et al, 2011;Jin et al, 2013), all of which were concerned with the association between SNP TNF-α-308G>A and the risk of oral cancer, and four studies were in regard to the SNP TNF-α-238G>A (Liu et al, 2005;Gupta et al, 2008;Kietthubthew et al, 2010;Yang et al, 2011). The whole process is shown in Figure 1.…”

Section: Eligible Studiesmentioning

confidence: 99%

“…One study (Yapijakis et al, 2009) was conducted in Europe, one study was in USA (Jin et al, 2013), and the remaining six studies were in Asia. Of which, four studies were conducted in Taiwan of China (Chiu et al, 2001;Chen et al, 2005;Liu et al, 2005;Yang et al, 2011), one study was conducted in India (Gupta et al, 2008;), and another was in Thailand (Kietthubthew et al, 2010). The subjects investigated were most males or all males.…”

Section: Meta-analysis Databasementioning

confidence: 99%

“…No heterogeneity was found between studies and the analyses were both conducted under fix-effect model. Additive and recessive genetic model were not presented because there was no distribution of genotype AA in the three available studies ( Liu et al, 2005;Gupta et al, 2008;Yang et al, 2011). Subgroup and sensitivity analyses were not carried out due to the small number of studies.…”

Section: Meta-analysis About Tnf-α-238g>a Polymorphismmentioning

confidence: 99%

“…Several studies have been conducted to try to confirm the association between TNF-α and the susceptibility of oral cancer (Chiu et al, 2001;Chen et al, 2005;Liu et al, 2005;Gupta et al, 2008;Yapijakis et al, 2009;Kietthubthew et al, 2010;Yang et al, 2011;Jin et al, 2013), but these have produced controversial or inconclusive results. We therefore performed a metaanalysis of all eligible studies to derive a more precise estimation of the association between TNF-α gene polymorphisms and oral cancer.…”

Section: Introductionmentioning

confidence: 99%

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Tumor Necrosis Factor-α Gene Polymorphisms and Risk of Oral Cancer: Evidence from a Meta-analysis

Chen¹,

Zhang²,

Zhang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Eligible Studiesmentioning

confidence: 99%

Section: Meta-analysis Databasementioning

confidence: 99%

Section: Meta-analysis About Tnf-α-238g>a Polymorphismmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tumor Necrosis Factor-α Gene Polymorphisms and Risk of Oral Cancer: Evidence from a Meta-analysis

Chen¹,

Zhang²,

Zhang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…It has been illustrated that the G to A nucleotide change at -308 alters the transcription factor binding site, resulting in increased production of TNF-α (Abraham and Kroeger 1999;Elahi et al 2009). Numerous studies have been carried out to investigate the association of this polymorphism with UADT cancer risk (Chiu et al 2001;Chen et al 2005;Guo et al 2005;Liu et al 2005;Gupta et al 2008;Canova et al 2009;Yapijakis et al 2009;Oh et al 2010;Whiteman et al 2010;Yang et al 2011a); however, the results of these studies remain controversial rather than conclusive. This might partly result from the small sample size of each study.…”

Section: Introductionmentioning

confidence: 99%

The -308G/A Polymorphism of the Tumor Necrosis Factor-alpha Gene Is Associated with the Risk of Upper Aerodigestive Tract Cancer: A Meta-analysis

Wang

Jin

Wang

et al. 2013

Tohoku J. Exp. Med.

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Tumor necrosis factor-alpha (TNF-α ) has been proposed to contribute to the development of upper aerodigestive tract (UADT) cancer that is characterized by poor prognosis. The G-to-A nucleotide change at -308 of the TNF-α gene (-308G/A polymorphism) can increase the expression level of TNF-α and thus may affect the genetic susceptibility of UADT cancer. The association between the -308G/A polymorphism and UADT cancer has been widely studied, but the results published are quite controversial. To obtain a more precise conclusion, we performed a meta-analysis including 1,751 patients and 3,345 controls. The results indicated that the AA genotype of the -308G/A polymorphism had a 54%-increased risk of UADT cancer, compared with the G carriers (GG and GA genotypes) [odds ratio (OR) = 1.54, 95% confidence interval (CI): 1.07-2.21]. After stratified by ethnicity, the AA genotype was associated with increased risk of UADT cancers in South Asians (OR = 33.18 and 95% CI: 1.92-573.62 for AA vs. GA+GG) but not in Caucasians or East Asians. After stratified by tumor site, the -308G/A polymorphism was associated with increased risks of oropharynx cancer (OR = 2.68 and 95% CI: 1.34-5.35 for AA vs. GA+GG) but not associated with esophagus or larynx cancer. After stratified by histological type, the -308G/A polymorphism was associated with increased risks of squamous cell carcinoma (OR = 1.81 and 95% CI: 1.15-2.84 for AA vs. GA+GG) but not associated with adenocarcinoma. Our results indicate that the -308G/A polymorphism might contribute to an increased risk of UADT cancer susceptibility.

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Genetic variants inTNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy

et al. 2013

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The promoter variants of TNF-α, a major regulator of immune and inflammation responses, have been implicated in cancer development and prognosis. Thus, we investigated associations between four TNF-α promoter variants and risk of recurrence of squamous cell carcinoma of the oropharynx (SCCOP). We evaluated associations of four TNF-α polymorphisms with risk of recurrence in a cohort of 846 patients with SCCOP. Log-rank test and multivariable Cox models were used to evaluate associations. Compared with patients with variant genotypes of the TNF-α −308 and TNF-α −863 polymorphisms, patients with common homozygous genotypes had worse disease-free survival (log-rank P = 0.0002 and P < 0.0001, respectively) and increased risk of SCCOP recurrence (HR, 1.9, 95% CI, 1.3–2.8 and HR, 1.9, 95% CI, 1.3–2.7, respectively) after multivariable adjustment. Furthermore, among patients with HPV16-positive tumors, those with common homozygous genotypes of the TNF-α −308 and −863 polymorphisms had worse disease-free survival (log-rank P = 0.005 and P = 0.007, respectively) and higher recurrence risk than patients with variant genotypes of these polymorphisms (HR, 5.1, 95% CI, 1.4–18.4 and HR, 3.7, 95% CI, 1.5–9.1, respectively), while no such significant associations were found for TNF-α −857 or −1031 polymorphisms. Our findings suggest that TNF-α −308 and −863 polymorphisms may modulate the risk of SCCOP recurrence in patients with HPV16-positive tumors. However, larger studies are needed to validate these results.

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Interaction between tumour necrosis factor-α gene polymorphisms and substance use on risk of betel quid-related oral and pharyngeal squamous cell carcinoma in Taiwan

Cited by 22 publications

References 33 publications

Tumor Necrosis Factor-α Gene Polymorphisms and Risk of Oral Cancer: Evidence from a Meta-analysis

Tumor Necrosis Factor-α Gene Polymorphisms and Risk of Oral Cancer: Evidence from a Meta-analysis

The -308G/A Polymorphism of the Tumor Necrosis Factor-alpha Gene Is Associated with the Risk of Upper Aerodigestive Tract Cancer: A Meta-analysis

Genetic variants inTNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy

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