Interaction between tramadol and two anti‐emetics on nociception and gastrointestinal transit in mice

Dürsteler, C.; Mases, A.; Fernández, Víctor; Pol, Olga; Puig, Margarita M.

doi:10.1016/j.ejpain.2005.10.002

Cited by 26 publications

(23 citation statements)

References 36 publications

(56 reference statements)

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“…Murat et al [16] found that when 5-HT 3 receptors were blocked by ondansetron, the antinociceptive effect of a selective serotonin reuptake inhibitor, paroxetine, was inhibited in mice. In addition, Dursteler et al [13] demonstrated the presence of antagonism between tramadol and ondansetron for the antinociceptive effects in mice, supporting our results in humans.…”

Section: Discussionsupporting

confidence: 79%

“…Animal and clinical trials have shown conflicting results about the analgesic efficacy of tramadol when coadministered with ondansetron [8,[10][11][12][13] . This is not surprising considering that those trials differed in their study protocols including studied subjects, type of surgeries, drugs used for anaesthesia, other analgesics allowed besides tramadol, time, dose and mode of administration of drugs.…”

Section: Discussionmentioning

confidence: 99%

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Co-Administration of Ondansetron Decreases the Analgesic Efficacy of Tramadol in Humans

Vale¹,

Oliveira²,

Assunção³

et al. 2011

Pharmacology

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Tramadol, a central analgesic acting on serotonin neurotransmission, is often co-used with ondansetron, a 5-HT₃ antagonist, for the management of postoperative pain to decrease nausea and vomiting. The aim of the study is to test the hypothesis that this drug combination raises tramadol requirement by patient-controlled analgesia (PCA). Forty patients undergoing hernioplasty or thyroidectomy were enrolled in a randomized, controlled study and allocated to receive ondansetron 4 mg i.v. (n = 20) or saline (n = 20). At 0, 1, 2, 4 and 24 h of PCA, tramadol consumption was evaluated. Tramadol consumption (mg × kg^–1 × h^–1) was higher in the ondansetron group at the 2-hour time point compared to the control group (0.24 ± 0.1 vs. 0.17 ± 0.16; p = 0.01). Our study suggests that ondansetron acutely reduces the analgesic efficacy of tramadol.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Co-Administration of Ondansetron Decreases the Analgesic Efficacy of Tramadol in Humans

Vale¹,

Oliveira²,

Assunção³

et al. 2011

Pharmacology

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“…Tramadol is also indicated for the management of mild-to-moderate postoperative pain, but its administration is associated with postoperative nausea and vomiting (PONV) [1,2]. We and others suggested that its analgesic efficacy is decreased by coadministration of ondansetron, a 5-HT 3 serotonin receptor antagonist [3,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…We and others suggested that its analgesic efficacy is decreased by coadministration of ondansetron, a 5-HT 3 serotonin receptor antagonist [3,4,5]. Recently, antagonism between tramadol and two antiemetics (ondansetron and droperidol) has been demonstrated in different animal models of nociception [2]. When administered perioperatively, glucocorticoids have antiemetic as well as analgesic effects [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone Effect on Postoperative Pain and Tramadol Requirement after Thyroidectomy

et al. 2013

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Tramadol is a central-acting analgesic associated with nausea and vomiting. Clinical studies have demonstrated that glucocorticoids have analgesic and antiemetic effects when administered perioperatively. The aim of this study is to test the hypothesis that coadministration of tramadol and dexamethasone decreases both postoperative pain and tramadol requirement by patient-controlled analgesia (PCA). Forty female patients undergoing thyroidectomy under general anesthesia were enrolled in a double-blind randomized controlled study and allocated to receive dexamethasone 4 mg i.v. (dexamethasone group, n = 20) or saline (control group, n = 20). At 0, 1, 2, 4 and 22 h of PCA, tramadol consumption and pain were evaluated. Although pain (numerical rating scale 0–10) was significantly lower in the dexamethasone group compared to the control group (2.9 ± 1.4 vs. 3.8 ± 1.2, p = 0.02) at the beginning of PCA, tramadol demand was not significantly different. Although the results herein show a possible beneficial effect of a preoperative single low dose of dexamethasone on postoperative pain, the hypothesis that this corticosteroid decreases tramadol requirement is not supported.

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“…However, animal and clinical studies have revealed that some anti-emetics could impair the analgesic efficacy of established analgesic drugs, such as paracetamol [2,3] and tramadol [4,5] , with different and complex mechanisms of action.Nefopam has shown antinociceptive properties in experimental models involving noxious and thermal pharmacological tests in rodents [6,7] . It is a clinically potent analgesic, frequently used during the post-operative period [8][9][10][11] .…”

mentioning

confidence: 99%

Modulation of Paracetamol and Nefopam Antinociception by Serotonin 5-HT<sub>3</sub> Receptor Antagonists in Mice

Girard

Pansart²,

Coppé³

et al. 2009

Pharmacology

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Background/Aims: Post-operative nausea and vomiting are common adverse events that require administration of anti-emetic compounds, such as the serotonin 5-HT₃ receptor antagonists, but these drugs can also reduce the analgesic efficacy of some analgesics (paracetamol, tramadol). Methods: The present study was designed to explore the effect of 3 serotonin 5-HT₃ receptor antagonists on the antinociceptive efficacy of another frequently used post-operative analgesic, nefopam, in the mouse writhing and formalin tests. Results: Pre-treatment with tropisetron, ondansetron or MDL72222 did not significantly modify nefopam antinociception in both tests. However, paracetamol antinociception was blocked by ondansetron in the formalin test. Conclusion: These results provide a rationale for the clinical use of nefopam with anti-emetics during surgery.

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Interaction between tramadol and two anti‐emetics on nociception and gastrointestinal transit in mice

Cited by 26 publications

References 36 publications

Co-Administration of Ondansetron Decreases the Analgesic Efficacy of Tramadol in Humans

Co-Administration of Ondansetron Decreases the Analgesic Efficacy of Tramadol in Humans

Dexamethasone Effect on Postoperative Pain and Tramadol Requirement after Thyroidectomy

Modulation of Paracetamol and Nefopam Antinociception by Serotonin 5-HT<sub>3</sub> Receptor Antagonists in Mice

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