Interaction between thyroid hormones and cellular constituents

Tata, Jamshed R.; Ernster, Lars; Suranyi, Eva M.

doi:10.1016/0006-3002(62)90866-1

Biochimica et Biophysica Acta

1962

DOI: 10.1016/0006-3002(62)90866-1

|View full text |Cite

Interaction between thyroid hormones and cellular constituents

Jamshed R. Tata¹,

Lars Ernster²,

Eva M. Suranyi³

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1962

2008

Publication Types

Select...

Article7

Relationship

Self Cite0

Independent7

Authors

Journals

Cited by 34 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The concept of a direct thyroid hormone effect on mitochondria has been supported by numerous previous reports (22)(23)(24)(25)(26)(27), especially the findings of Bronk (22), which have suggested immediate effects on oxidative phosphorylation. This concept is in no way incompatible with stimulation of nuclear transcription (1)(2)(3)(4), which is regarded as a probable sustained effect after a lag required for activation of protein synthesis.…”

mentioning

confidence: 76%

See 1 more Smart Citation

Thyroid Hormone Action: The Mitochondrial Pathway

Sterling

Milch

Brenner

et al. 1977

Science

166

View full text Add to dashboard Cite

tions. By means of a table of random numbers, the two lesions that would receive an application from tube A were determined (two of lesions 1, 2, 3, and 4). The other two lesions received an application from tube B. 15. After the two lesions that were to receive an application from tube A were determined, one was randomly selected to be a biopsy site; likewise, the two lesions that were to receive an application from tube B were selected randomly. Therefore, one of the two lesions from each treatment was scheduled to be biopsied but the code (tube A and tube B) was not broken until after biochemical analyses were completed. The two remaining lesions, one having received a glucocorticoid and one a control cream treatment, were not biopsied but were left to be visually evaluated 2 days later. 16. J. J. Voorhees, E. A. Duell, M. Stawiski, E. R.Harrell, Adv. Cyclic Nucleotide Res. 4, 11717. The surgically removed treated or control tissue used as starting material in this report is designated by several terms which are meant to be synonymous. These terms are lesional epithelium,-lesional epidermis, lesional tissue, and diseased tissue. By frozen section histology we estimate that keratinocytic epithelium (epidermis) occupies 80 to 95 percent of the specimen volume. The 80 to 95 percent range is the result of surgical technique, vertical lesional configuration, and the presence of non-keratinocytes (inflammation-associated cells, endothelial cells, fibroblasts, and collagen). Therefore, although 5 to 20 percent of the specimen volume is occupied by collagen and nonepithelial cells, the latter of which probably contain the arachidonic acid transformation cascade (Fig. 2), it seems probable that the data in Fig. I are derived mainly from lesional epithelium. 18.

show abstract

mentioning

confidence: 76%

“…89, 579 (1964). 25. C. Pace-Asciak, K CaCl2 in tap water were kept at least 1 month on a low-iodine diet, by which time hypothyroid stigmata had become obvious and serum triiodothyronine (T3) and thyroxine (T4) concentrations were in the hypothyroid range.…”

mentioning

confidence: 99%

Thyroid Hormone Action: The Mitochondrial Pathway

Sterling

Milch

Brenner

et al. 1977

Science

166

View full text Add to dashboard Cite

show abstract

“…The identification of many of the key hormones and neuropeptides involved in appetite and energy balance regulation, such as neuropeptide Y (NPY), leptin and melanocortin, has occurred only relatively recently. Nevertheless long before the discovery of these neuropeptides and hormones, thyroid hormone was known to alter metabolic rate [1,2] and has been used in various forms to reduce weight since the 1940s [3]. Despite the fact that thyroid hormone was one of the earliest known hormones to affect body weight, little is known about how thyroid hormone acts in the brain to regulate appetite and energy expenditure.…”

mentioning

confidence: 99%

Hypothalamic Thyroid Hormone in Energy Balance Regulation

Herwig¹,

Ross²,

Nilaweera³

et al. 2008

Obes Facts

View full text Add to dashboard Cite

Thyroid hormone has been known for decades as a hormone with profound effects on energy expenditure and ability to control weight. The regulation of energy expenditure by thyroid hormone primarily occurs via regulation of the activity, or expression, of uncoupling proteins in peripheral tissues. However, mechanistically this requires a signal from the brain to change circulating levels of thyroxine and thyroid hormone or increased sympathetic drive to peripheral tissues to alter local thyroid hormone levels via increased expression of type 2 deiodinase. However, little consideration has been given to the potential role and involvement of thyroid hormones action in the brain in the regulation of energy balance. Recent evidence implicates thyroid hormone as a shortterm signal of energy deficit imposed by starvation. Furthermore, thyroid hormone action within the hypothalamus is involved in adjusting long-term energy expenditure in seasonal animals which endure food shortages in winter. Evidence from several studies suggests that regulation of type 2 and type 3 deiodinase enzymes in tanycytes of the third ventricle are gatekeepers of thyroid hormone levels in the hypothalamus. This paper reviews some of the evidence for the role of deiodinase enzymes and the actions of thyroid hormone in the hypothalamus in the regulation of energy balance.

show abstract

Ecdysonbindende Proteinfraktionen in den Speicheldr�sen von Drosophila hydei

Emmerich

1970

Z. Vergl. Physiol.

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Interaction between thyroid hormones and cellular constituents

Cited by 34 publications

References 30 publications

Thyroid Hormone Action: The Mitochondrial Pathway

Thyroid Hormone Action: The Mitochondrial Pathway

Hypothalamic Thyroid Hormone in Energy Balance Regulation

Ecdysonbindende Proteinfraktionen in den Speicheldr�sen von Drosophila hydei

Contact Info

Product

Resources

About