Interaction Between Smoking and Internet Gaming Disorder on Spontaneous Brain Activity

Qiu, Xianxin; Han, Xu; Wang, Yao; Ding, Weiping; Sun, Yawen; Zhou, Yan; Lei, Hao; Lin, Fuchun Joseph

doi:10.3389/fpsyt.2020.586114

Cited by 9 publications

(5 citation statements)

References 84 publications

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“…Kim et al (18) and Na et al (19) showed that the time spent playing internet games is closely related to the degree of alcohol consumption, but Poorolajal et al (20) found no significant correlation between the two. Some studies have suggested that smokers might more easily develop IAD (21,22). Furthermore, a study on 467 Chinese adolescents demonstrated that individuals with IAD or IGD might engage in more risky behaviors (skipping school, smoking, drinking, fighting, gambling, stealing) (23).…”

Section: Introductionmentioning

confidence: 99%

Assessing the Association Between Internet Addiction Disorder and Health Risk Behaviors Among Adolescents and Young Adults: A Systematic Review and Meta-Analysis

Wang

Hao

et al. 2022

Front. Public Health

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BackgroundInternet addiction disorder (IAD) is a global issue that has resulted in a slew of physical and emotional consequences. Studies have indicated that health risk behaviors might be the risk factors for IAD. The published literature on the correlation between the two is lacking. Therefore, we conducted a comprehensive analysis to understand better the link between IAD and health risk behaviors among adolescents and young adults.MethodsWe searched ten electronic databases for relevant articles. Data were extracted based on IAD and health risk behaviors ( alcohol, smoking, suicidal, gambling and drug abuse). We calculated odds ratios (ORs), a pooled correlation coefficient (r) and 95% confidence intervals (CIs). A fixed-effect model was applied to summarize the pooled effects. Heterogeneity was examined using I2 statistics and Cochran's Q statistics. All analyses were conducted by using Stata version 15.0.ResultsA total of 16 studies and 61,823 participants were included in this study. Meta-analysis showed that IAD was positively correlated with drinking (r = 0.35; 95% CI 0.32–0.37) and smoking (r = 0.12; 95%CI 0.10–0.15), and was associated with an increased risk of suicidal behavior (OR= 1.95; 95% CI 1.65–2.30), drinking (OR= 1.75; 95% CI 1.65–1.85), and smoking (OR= 1.63; 95% CI 1.54–1.72) among adolescents.ConclusionWe found significantly increased risks of suicidal behavior, drinking, and smoking in adolescents and young adults with IAD. These findings are important to expand our understanding of IAD and have great guiding significance for preventing health risk behaviors of adolescents and young adults.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021257729, identifier: PROSPERO CRD42021257729.

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Section: Introductionmentioning

confidence: 99%

Assessing the Association Between Internet Addiction Disorder and Health Risk Behaviors Among Adolescents and Young Adults: A Systematic Review and Meta-Analysis

Wang

Hao

et al. 2022

Front. Public Health

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“…Abnormalities in ALFF values in brain regions have been found in previous studies in the presence of internet addicts, for example in a study comparing adolescents with online game addiction to professional gamers found abnormalities in prefrontal regions [22,23] , and in a long term study by Kwak and coworkers adolescents with online game addiction showed higher ALFF in the orbitofrontal cortex [24] . In addition,another long-term study by Han et al examined changes in ALFF before and after 12 sessions of cognitive-behavioral therapy in adolescents with Internet addiction and healthy controls.…”

Section: Discussionmentioning

confidence: 68%

Dynamic changes of regional brain activity in adolescents with internet gaming disorder

Lang,

Wang,

et al. 2023

Preprint

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This study aimed to explore the dynamic changes of regional brain activity in adolescent with Internet Gaming Disorder (IGD) based on the analysis of dynamic low-frequency amplitude. Methods: Forty-four patients with IGD and 50 age-, sex-, and education-matched healthy controls (HC group) were recruited for resting state magnetic resonance imaging analysis of their regional brain activities. The collected imaging data was analyzed using two independent-sample t-test in which the MATLAB software was used to extract dynamic amplitude of low-frequency fluctuation (dALFF) values of abnormal active brain regions. Person correlation analysis were used to analyze the Internet Addiction Test (IAT) and the SCL-90 scores. Finally, IAT scores, factor scores in the SCL-90 scale and dALFF values of abnormal brain regions in the IGD group were analyzed for moderating effects using the process 4.1 plug-in of the SPSS26 statistical software. p < 0.05 suggests the existence of regulatory effects. Results: IGD group exhibited alterations in the local dynamic activity of signals in several brain regions, compared to HC group. Reduced dALFF values were mainly found in the inferior temporal gyrus, precuneus, posterior cerebellum lobe, and cerebellum vermis regions. The results of dynamic low-frequency amplitude analysis showed a negative correlation between left precuneus dALFF values and IAT scores in the IGD group (r=-0.403, p = 0.008). The results of the correlation analysis with the clinical scale indicated that the dALFF values in the left posterior cerebellum lobe (cerebellum region VI) were negatively correlated with the interpersonal sensitivity factor score (r=-0.314, p = 0.034) and depression factor score (r=-0.342, p = 0.033) in the SCL-90 scale. Conclusions: IGD in adolescents may have an impact on their mental health, and the severity of Internet gaming disorder may play a moderating role between the posterior cerebellum lobe and the mental health status of adolescent Internet addicts, which may provide some useful information in the future to explain clinical phenomena such as Internet addicts with different degrees of emotional problems.

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“…The detailed demographic and clinical information were the same as in our previous study ( Qiu et al, 2020 ) and are listed in Supplementary Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…However, there have been no studies conducted on the rsFC of smoking and IGD comorbidities and the interaction effects between smoking and IGD in reward and memory circuits. Our previous studies found significant interaction effects between smoking and IGD on spontaneous brain activity and functional brain networks ( Qiu et al, 2020 , 2022 ). Therefore, we assume that there may also be interaction effects between smoking and IGD on rsFC of the VTA and hippocampus.…”

Section: Introductionmentioning

confidence: 90%

Interaction effects between smoking and internet gaming disorder on resting-state functional connectivity of the ventral tegmental area and hippocampus

Qiu,

Han,

Wang

et al. 2023

Front. Neurosci.

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BackgroundMany reports have focused on cigarette smoking and internet gaming disorder (IGD), with widespread alterations of resting-state functional connectivity (rsFC) in the reward and memory circuits, respectively. Epidemiological studies have also shown high comorbidity of cigarette smoking and IGD. However, the underlying mechanisms are still unknown. Therefore, this study investigates the comorbidity and interaction effects between smoking and IGD from the rsFC perspective.MethodsResting-state functional magnetic imaging data were collected from 60 healthy controls (HC), 46 smokers, 38 IGD individuals, and 34 IGD comorbid with smoking (IGDsm) participants. Voxel-wise rsFC maps were calculated for all subjects with the ventral tegmental area, rostral hippocampus, and caudal hippocampus as regions of interest, respectively.ResultsSignificant interaction effects between smoking and IGD were mainly involved in the reward and memory circuits; that is, the rsFC between the ventral tegmental area and right nucleus accumbens, between the rostral hippocampus and bilateral nucleus accumbens, sensorimotor areas, and left middle temporal gyrus. Specifically, in these circuits, smokers showed decreased rsFC compared to the HC group, while IGDsm showed increased rsFC compared to smokers and IGD individuals. The IGDsm and HC groups showed no significant difference. The altered rsFC also correlated with clinical measures.ConclusionThese findings indicate that lower rsFC in smokers or IGD individuals increases under the effect of another type of addiction, such as smoking and IGD, but only increases to the normal state, which might explain the comorbidity and interaction between smoking and IGD from the perspective of functional circuits.

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Interaction Between Smoking and Internet Gaming Disorder on Spontaneous Brain Activity

Cited by 9 publications

References 84 publications

Assessing the Association Between Internet Addiction Disorder and Health Risk Behaviors Among Adolescents and Young Adults: A Systematic Review and Meta-Analysis

Assessing the Association Between Internet Addiction Disorder and Health Risk Behaviors Among Adolescents and Young Adults: A Systematic Review and Meta-Analysis

Dynamic changes of regional brain activity in adolescents with internet gaming disorder

Interaction effects between smoking and internet gaming disorder on resting-state functional connectivity of the ventral tegmental area and hippocampus

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