Interaction between smoking and depressive symptoms with subclinical heart disease in the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Carroll, Allison J.; Carnethon, Mercedes R.; Liu, Kiang; Jacobs, David R.; Colangelo, Laura A.; Stewart, Jesse C.; Carr, J. Jeffrey; Widome, Rachel; Auer, Reto; Hitsman, Brian

doi:10.1037/hea0000425

Cited by 24 publications

(19 citation statements)

References 62 publications

(83 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The depressive symptoms observed here failed to achieve a diagnosis of depression since the level of the symptoms was below the lower threshold used for psychiatric diagnosis (16/60) [24]. The range of CES-D values we observed was similar to that of a young adult population included in a large longitudinal study [27]. In these young subjects, cumulative exposure to such a level of depressive symptoms was shown to be associated with increased incidence of vascular wall pathology.…”

Section: Discussionsupporting

confidence: 46%

“…This was an exploratory study with no sample size calculation. In subjects with metabolic syndrome, a weight-decreasing diet intervention was shown to be associated with simultaneous decreases in adiposity, inflammatory markers, and depressive symptoms [27]. An RCT in major depression in adults showed an improvement in the dietary intervention group [31].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Quality of Life: Psychological Symptoms—Effects of a 2-Month Healthy Diet and Nutraceutical Intervention; A Randomized, Open-Label Intervention Trial (RISTOMED)

et al. 2020

View full text Add to dashboard Cite

Depression symptoms and lower health-related quality of life (HRQoL) are associated with inflammation. This multicenter dietary intervention was shown to reduce inflammation in older people. This was the main outcome. Here, we describe the effects on HRQoL, anxiety, and depressive symptoms according to inflammation status. Overall, 125 healthy older subjects (65–80 year) were recruited (Italy, France, and Germany) and randomized into four arms (A, Healthy diet (HD); B, HD plus De Simone Formulation probiotic blend; C, HD plus AISA d-Limonene; D, HD plus Argan oil). The HD was weight maintaining, rich in antioxidant vitamins, polyphenols, polyunsaturated fatty acids (n6: n3 ratio = 3:1), and fiber. Data on inflammatory parameters, mental (MCS) and physical (PCS) component summaries of HRQoL (SF−36), anxiety symptoms (STAI state), and depressive symptoms (CES-D) were collected before and after 56 days of intervention. Body fat mass proportion (BFM) was considered a co-variable. A decrease of CES-D score was seen in the four arms (A: −40.0%, p = 0.001; B: −32.5%, p = 0.023; C: −42.8%, p = 0.004; and D: −33.3%, p = 0.21). Within the subgroups of subjects with medium/high inflammation a similar decrease in CES-D score occurred in all groups (A: −44.8%, p = 0.021; B, −46.7%, p = 0.024; C, −52.2%, p = 0.039; D, −43.8%, p = 0.037). The effect of interventions on CES-D was not related to baseline inflammation. MCS-HRQoL improved in A and C. There was no change in anxiety or PCS-HRQoL. In this trial with no control group, a decrease in depressive symptoms in healthy older volunteers was observed after a 2-month healthy diet intervention, independently of inflammation but with possible limitations due to participation.

show abstract

Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Quality of Life: Psychological Symptoms—Effects of a 2-Month Healthy Diet and Nutraceutical Intervention; A Randomized, Open-Label Intervention Trial (RISTOMED)

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A strength of our study is the cumulative measures of depressive symptoms and smoking exposure, as cumulative measures are superior to concurrent measures in predicting CAC (Loria et al, 2007). In particular, these measurements better modeled the chronic nature of smoking and depression, as well as the synergistic accumulation of risk associated with CAC (Carroll et al, In Press). …”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported significant relationships between depressive symptomatology and CAC (e.g., Hamer, Kivimaki, Lahiri, Marmot, & Steptoe, 2010). Furthermore, in a recent study, we observed that smoking and depressive symptoms had a synergistic association with subclinical atherosclerosis, where higher lifetime smoking exposure and depressive symptoms were synergistically associated with higher odds of CAC (Carroll et al, In Press). …”

mentioning

confidence: 92%

“…Using methodology consistent with our recent study (Carroll et al, In Press), we evaluated the association of depressive symptom clusters and smoking exposure accumulated over 25 years with CAC at Year 25 in the CARDIA study. We used a 14-item, 3-factor (negative affect, anhedonia, somatic symptoms) characterization of the Center for Epidemiologic Studies Depression (CES-D) scale (Carleton et al, 2013).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Association of the Interaction Between Smoking and Depressive Symptom Clusters With Coronary Artery Calcification: The CARDIA Study

Carroll

Auer

Colangelo

et al. 2017

Journal of Dual Diagnosis

Self Cite

View full text Add to dashboard Cite

Objective Depressive symptom clusters are differentially associated with prognosis among patients with cardiovascular disease (CVD). Few studies have prospectively evaluated the association between somatic symptoms and risk for CVD. Previously, we observed that smoking and total depressive symptoms were synergistically associated with coronary artery calcification (CAC). The purpose of this study was to determine whether the smoking by depressive symptoms interaction, measured cumulatively over 25 years, differed by depressive symptom cluster (negative affect, anhedonia, and somatic symptoms) in association with CAC. Methods Participants (N=3,189: 54.5% female; 51.5% Black; average age=50.1 years) were followed from 1985–1986 through 2010–2011 in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Smoking exposure was measured by cumulative cigarette packyears (cigarette packs smoked per day × number of years smoking; Year 0 through Year 25). Depressive symptoms were measured using a 14-item, 3-factor (negative affect, anhedonia, somatic symptoms) analysis of the Center for Epidemiologic Studies Depression (CES-D) Scale (Years 5, 10, 15, 20, and 25). CAC was assessed at Year 25. Logistic regression models were used to evaluate the association between the smoking by depressive symptom clusters interactions with CAC (=0 vs. >0), adjusted for CVD-related sociodemographic, behavioral, and clinical covariates. Results 907 participants (28% of the sample) had CAC >0 at Year 25. The depressive symptom clusters did not differ significantly between the two groups. Only the cumulative somatic symptom cluster by cumulative smoking exposure interaction was significantly associated with CAC >0 at Year 25 (p=.028). Specifically, adults with elevated somatic symptoms (score 9 out of 18) who had 10, 20, or 30 packyears of smoking exposure had respective odds ratios (95% confidence intervals) of 2.06 (1.08–3.93), 3.71 (1.81–7.57), and 6.68 (2.87–15.53), ps<.05. Negative affect and anhedonia did not significantly interact with smoking exposure associated with CAC >0, ps>.05. Conclusions Somatic symptoms appear to be a particularly relevant cluster of depressive symptomatology in the relationship between smoking and CVD risk.

show abstract

Ischemic Heart Disease, Depression, and Tobacco Smoking

Carroll

2020

The Wiley Encyclopedia of Health Psychology

View full text Add to dashboard Cite

Interaction between smoking and depressive symptoms with subclinical heart disease in the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Cited by 24 publications

References 62 publications

Quality of Life: Psychological Symptoms—Effects of a 2-Month Healthy Diet and Nutraceutical Intervention; A Randomized, Open-Label Intervention Trial (RISTOMED)

Quality of Life: Psychological Symptoms—Effects of a 2-Month Healthy Diet and Nutraceutical Intervention; A Randomized, Open-Label Intervention Trial (RISTOMED)

Association of the Interaction Between Smoking and Depressive Symptom Clusters With Coronary Artery Calcification: The CARDIA Study

Ischemic Heart Disease, Depression, and Tobacco Smoking

Contact Info

Product

Resources

About