Interaction between sex and early-life stress: Influence on epileptogenesis and epilepsy comorbidities

Jones, Nigel C.; O’Brien, Terence J.; Carmant, Lionel

doi:10.1016/j.nbd.2014.09.004

Cited by 28 publications

(18 citation statements)

References 110 publications

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“…There are limited studies focusing on the effects of repeated neonatal maternal separation on seizure susceptibility. Most of these investigations reported that MS increases the risk of limbic epileptogenesis and stated that such effect is sex-specific [2,3]. These observations are in agreement with the fact that the prevalence of some mental disorders such as depression and mesial temporal lobe epilepsy (MTLE) is higher in women [24].…”

Section: Discussionsupporting

confidence: 64%

“…Emerging lines of research indicate that exposure to stress during one's lifespan has negative effects on seizure activity. Specifically, experiencing chronic stress during development of the brain has been reported to alter seizure susceptibility in adulthood [2,3]. In this regard, there are pieces of evidence suggesting that early-life stress such as maternal separation (MS) adversely affects brain development and increases the risk of occurrence of behavioral difficulties [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system

Amini-Khoei

Amiri

Shirzadian

et al. 2015

Epilepsy & Behavior

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system

Amini-Khoei

Amiri

Shirzadian

et al. 2015

Epilepsy & Behavior

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“…Further, it is important to consider possible differential vulnerabilities in males and females to early glucocorticoid administration. Sex differences in the effects of early-life stress and of glucocorticoid administration, including effects on the hippocampus, have frequently have been observed (e.g., Bale & Epperson, 2015; Gobinath et al, 2016; Jones et al, 2014). A better understanding of how males and females differ in the response to early glucocorticoid treatment may shed light on the differential prevalence of developmental disorders in males and females (e.g., more ADHD and autism in males; more depression in females).…”

Section: 0 Introductionmentioning

confidence: 99%

Influence of postnatal glucocorticoids on hippocampal-dependent learning varies with elevation patterns and administration methods

Claflin

Schmidt

Vallandingham

et al. 2017

Neurobiology of Learning and Memory

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Recent interest in the lasting effects of early-life stress has expanded to include effects on cognitive performance. An increase in circulating glucocorticoids is induced by stress exposure and glucocorticoid effects on the hippocampus likely underlie many of the cognitive consequences. Here we review studies showing that corticosterone administered to young rats at the conclusion of the stress-hyporesponsiveness period affects later performance in hippocampally-mediated trace eyeblink conditioning. The nature and even direction of these effects varies with the elevation patterns (level, duration, temporal fluctuation) achieved by different administration methods. We present new time course data indicating that constant glucocorticoid elevations generally corresponded with hippocampus-mediated learning deficits, whereas acute, cyclical elevations corresponded with improved initial acquisition. Sensitivity was greater for males than for females. Further, changes in hippocampal neurogenesis paralleled some but not all effects. The findings demonstrate that specific patterns of glucocorticoid elevation produced by different drug administration procedures can have markedly different, sex-specific consequences on basic cognitive performance and underlying hippocampal physiology. Implications of these findings for glucocorticoid medications prescribed in childhood are discussed.

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“…Environmental events, grouped under the umbrella of early‐life adversity or early‐life stress (ELS), are now recognised as a major preventable cause of future psychiatric disorders including anxiety, depression and substance abuse . Indeed, prior ELS may additionally be a risk factor for the future manifestation of some neurological disorders (eg, certain forms of epilepsy) . Clinically, these terms describe a variety of negative experiences early in life, ranging from poverty and malnutrition to physical and emotional trauma, or abuse …”

Section: Neurosteroids Early‐life Adversity and Psychiatric Disordersmentioning

confidence: 99%

Endogenous neurosteroids influence synaptic GABA_A receptors during postnatal development

Belelli

Brown

Mitchell

et al. 2018

J Neuroendocrinology

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GABA plays a key role in both embryonic and neonatal brain development. For example, during early neonatal nervous system maturation, synaptic transmission, mediated by GABA A receptors (GABA A Rs), undergoes a temporally specific form of synaptic plasticity to accommodate the changing requirements of maturing neural networks. Specifically, the duration of miniature inhibitory postsynaptic currents (mIPSCs), resulting from vesicular GABA activating synaptic GABA A Rs, is reduced, permitting neurones to appropriately influence the window for postsynaptic excitation. Conventionally, programmed expression changes to the subtype of synaptic GABA A R are primarily implicated in this plasticity. However, it is now evident that, in developing thalamic and cortical principaland inter-neurones, an endogenous neurosteroid tone (eg, allopregnanolone) enhances synaptic GABA A R function. Furthermore, a cessation of steroidogenesis, as a result of a lack of substrate, or a co-factor, appears to be primarily responsible for early neonatal changes to GABAergic synaptic transmission, followed by further refinement, which results from subsequent alterations of the GABA A R subtype. The timing of this cessation of neurosteroid influence is neurone-specific, occurring by postnatal day (P)10 in the thalamus but approximately 1 week later in the cortex. Neurosteroid levels are not static and change dynamically in a variety of physiological and pathophysiological scenarios.Given that GABA plays an important role in brain development, abnormal perturbations of neonatal GABA A R-active neurosteroids may have not only a considerable immediate, but also a longer-term impact upon neural network activity. Here, we review recent evidence indicating that changes in neurosteroidogenesis substantially influence neonatal GABAergic synaptic transmission. We discuss the physiological relevance of these findings and how the interference of neurosteroid-GABA A R interaction early in life may contribute to psychiatric conditions later in life. K E Y W O R D Scortex, GABA A receptor, neurosteroid, synaptic inhibition, thalamus

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Interaction between sex and early-life stress: Influence on epileptogenesis and epilepsy comorbidities

Cited by 28 publications

References 110 publications

Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system

Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system

Influence of postnatal glucocorticoids on hippocampal-dependent learning varies with elevation patterns and administration methods

Endogenous neurosteroids influence synaptic GABA_A receptors during postnatal development

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Interaction between sex and early-life stress: Influence on epileptogenesis and epilepsy comorbidities

Cited by 28 publications

References 110 publications

Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system

Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system

Influence of postnatal glucocorticoids on hippocampal-dependent learning varies with elevation patterns and administration methods

Endogenous neurosteroids influence synaptic GABAA receptors during postnatal development

Contact Info

Product

Resources

About

Endogenous neurosteroids influence synaptic GABA_A receptors during postnatal development