Interaction between Selected Adipokines and Musculoskeletal and Cardiovascular Systems: A Review of Current Knowledge

Sierawska, Olga; Sawczuk, Marek

doi:10.3390/ijms242417287

Cited by 5 publications

(2 citation statements)

References 134 publications

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“…Masno tkivo nije samo pasivni izvor slobodnih masnih kiselina, već aktivni endokrini i parakrini organ koji luči brojne medijatore -adipokine, kao što su: faktor nekroze tumora alfa (TNF-), interleukin-6 (IL-6), interleukin-1-beta, adiponektin, rezistin, serumski amiloid A-3 (SAA3), alfa 1-kiseli glikoprotein, pentraksin-3, inhibitorni faktor migracije makrofaga, antagonist receptora interleukina-1, angiotenzinogen, inhibitor aktivatora plazminogena (PAI-1), leptin, visfatin, vaskularni endotelni faktor rasat (VEGF) (13). Pomenuti adipokini učestvuju u različitim metaboličkim procesima, uključujući regulaciju unosa hrane, ponašanje u ishrani, vaskularni tonus, metabolizam masti, utiču na energetsku ravnotežu i osetljivost na insulin.…”

Section: Obim Strukaunclassified

Obesity and consequent changes in the body

Kisić,

Puhalo-Sladoje,

Mirić

et al. 2022

Praxis medica

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Obesity is one of the most common chronic, non-infectious diseases in the world and our country, and it is characterized by excessive accumulation of fat tissue in the body and an increase in body weight. The increase in the number of obese people is an important global health problem. Obesity is associated with cardiometabolic and psychosocial comorbidities, and may also affect years of healthy life and reduce life expectancy. Numerous factors, such as biological predisposition, socioeconomic factors and environmental factors, interact and influence the development and maintenance of obesity. Excess adipose tissue in the body and its dysfunction is associated with inflammation and increased risk of metabolic, mechanical and mental complications. It is very important to monitor the incidence of obesity and its impact on the development of chronic non-communicable diseases and life expectancy due to the development and implementation of strategies to prevent the increase in the number of obese people.

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Section: Obim Strukaunclassified

Obesity and consequent changes in the body

Kisić,

Puhalo-Sladoje,

Mirić

et al. 2022

Praxis medica

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“…This Special Issue also comprehensively elucidates the broader systemic effects of cytokines, as evidenced by two reviews: one on adipokines in the musculoskeletal and cardiovascular systems and one on the potential of cytokines as biomarkers for physical exercise [ 8 , 9 ]. These articles not only further our appreciation of the systemic nature of cytokine activity but also emphasize the translational potential of cytokine research in enhancing athletic performance and managing chronic diseases.…”

Section: Introductionmentioning

confidence: 99%

Editorial for the Special Issue “Cytokines in Inflammatory Signaling”

Chong

2024

IJMS

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The role of asprosin in regulating ovarian granulosa- and theca-cell steroidogenesis: a review with comparisons to other adipokines

Maylem,

Schütz,

Spicer

2024

Reprod. Fertil. Dev.

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Adipose tissues produce a variety of biologically active compounds, including cytokines, growth factors and adipokines. Adipokines are important as they function as endocrine hormones that are related to various metabolic and reproductive diseases. The goal of this review was to summarise the role of asprosin, a recently discovered adipokine, and compare its role in ovarian steroidogenesis with that of other adipokines including adiponectin, leptin, resistin, apelin, visfatin, chemerin, irisin, and gremlin 1. The summary of concentrations of these adipokines in humans, rats and other animals will help researchers identify appropriate doses to test in future studies. Review of the literature indicated that asprosin increases androstenedione production in theca cells (Tc), and when cotreated with FSH increases oestradiol production in granulosa cells (Gc). In comparison, other adipokines (1) stimulate Gc oestradiol production but inhibit Tc androgen production (adiponectin), (2) inhibit Gc oestradiol production and Tc androstenedione production (leptin and chemerin), (3) inhibit Gc steroidogenesis with no effect on Tc (resistin), (4) inhibit Gc oestradiol production but stimulate Tc androgen production (gremlin 1), and (5) increase steroid secretion by Gc, with unknown effects on Tc steroidogenesis (apelin and visfatin). Irisin has direct effects on Gc but its precise role (inhibitory or stimulatory) may be species dependent and its effects on Tc will require additional research. Thus, most adipokines have direct effects (either positive or negative) on steroid production in ovarian cells, but how they all work together to create a cumulative effect or disease will require further research.

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Interaction between Selected Adipokines and Musculoskeletal and Cardiovascular Systems: A Review of Current Knowledge

Cited by 5 publications

References 134 publications

Obesity and consequent changes in the body

Obesity and consequent changes in the body

Editorial for the Special Issue “Cytokines in Inflammatory Signaling”

The role of asprosin in regulating ovarian granulosa- and theca-cell steroidogenesis: a review with comparisons to other adipokines

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