Interaction between rosuvastatin and rocuronium in rat sciatic-gastrocnemius nerve-muscle preparation

Panchasara, Ashwin K.; Patel, Jayshree C.; Vadgama, Vishalkumar K.; Barvaliya, Manish; Tripathi, C. B.

doi:10.1007/s00540-014-1792-z

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Considering the pharmacokinetics, disposition, and liver-specific distribution of rosuvastatin in vivo, we calculated the concentration, which ranged from 1 to 100 mmol/L. Additionally, the dosages of rosuvastatin previously used in the rat model were 2 mg/kg/day, 25 5 mg/kg/ day, 19 10 mg/kg/day, and 15 mg/kg/day. 20 The dosage we used in vivo was within the range of previously reported studies.…”

Section: Discussionmentioning

confidence: 99%

Rosuvastatin for enhancement of aneurysm neck endothelialization after coil embolization: promotion of endothelial progenitor cells in a rodent model

Liu

Chen

et al. 2016

JNS

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OBJECT Coil embolization is a safe, efficient, and minimally invasive technique for the treatment of intracranial aneurysms. However, coil embolization is associated with a higher risk of recurrence than clip ligation. In this study, the authors explore a new approach through the promotion of endothelial progenitor cells (EPCs) to optimize endothelialization of the aneurysm neck and reduce the risk of recurrence. METHODS A coiled aneurysm model was created in 48 adult male Sprague-Dawley rats via microsurgery. Half of these animals were treated with rosuvastatin (20 mg/kg) in saline via gavage for 10, 20, or 30 days. The other half were administered saline without rosuvastatin. An additional 15 rats underwent “mock surgery” (identical anesthesia and saline gavage but no surgery). The endothelial repair process in the coiled aneurysms was evaluated via flow cytometry, im-munostaining, and electronic microscopy. The mock surgery group was used for comparison in flow cytometry studies. The effects of rosuvastatin on viability and functioning of Sprague-Dawley rat bone marrow-derived EPCs were also explored via MTT, migration, and tube formation assays. RESULTS The aneurysm neck repair score was significantly higher in the rosuvastatin-treated rats than in the untreated rats (p < 0.05). The circulating EPC count was increased and maintained at a higher level in rosuvastatin-treated rats compared with the aneurysm rats that did not receive rosuvastatin (p < 0.05). Immunostaining showed that the aneurysm neck endothelium was more integrated and the number of kinase insert domain receptor-positive cells was increased in the rosuvastatin-treated rats. Further study demonstrated that rosuvastatin promoted EPC proliferation, migration, and tube formation. CONCLUSIONS Rosuvastatin promoted endothelialization of the coiled aneurysm neck via induction of EPCs, suggesting that promoting endothelialization provides an additional therapeutic opportunity during vascular endothelium repair.

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Section: Discussionmentioning

confidence: 99%

Rosuvastatin for enhancement of aneurysm neck endothelialization after coil embolization: promotion of endothelial progenitor cells in a rodent model

Liu

Chen

et al. 2016

JNS

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“… showed that depolarizing NMBA succinylcholine caused minor muscle injuries in patients taking statins for over 3 months. One study showed that pre‐treatment with rosuvastatin delayed the recovery and increased the blocking potency of the non‐depolarizing NMBA rocuronium in sciatic gastrocnemius nerve muscle preparation of rat . The effect of statins on non‐depolarizing NMBA is unclear in a clinical setting.…”

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confidence: 99%

Neuromuscular Effects of Rocuronium Bromide in Patients in Statin Therapy for at least Three Months

Ren

2016

Basic Clin Pharma Tox

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Statins cause skeletal muscle myopathy. However, the neuromuscular effects of non-depolarizing neuromuscular-blocking agent in patients in long-term statin therapy remain unclear. Hence, we investigated the neuromuscular effects of rocuronium and muscle injury in patients in long-term statin therapy. Eighteen statin users using statins for at least 3 months were included in the statin group and 18 non-statin users were included in the non-statin group. General anaesthesia was induced with intravenous midazolam, etomidate, sufentanil and rocuronium 0.9 mg/kg (3ED ) for intubation. Anaesthesia was maintained with 1% propofol and remifentanil. The onset time and duration 10% T and 25% T of rocuronium were recorded. Blood samples were obtained before induction and 5 min., 1 hr, 2 hr, 4 hr, 12 hr and 24 hr after rocuronium administration to measure creatine kinase (CK), myoglobin and potassium. Myalgia was determined at 2 and 24 hr after surgery. There were no significant differences in the basic clinical characteristics between the two groups. The onset time of the statin group was significantly shorter than that of the non-statin group (p = 0.02), while the duration 10% T and duration 25% T of the statin group were significantly longer than those of the non-statin group (p = 0.006; p = 0.045). The myoglobin and CK concentrations increased after rocuronium administration as compared to baseline in both groups. CK concentration in the statin group was significantly higher than in the non-statin group just at 24 hr (p = 0.000003). However, myoglobin showed no significant difference between the two groups. The onset time of rocuronium decreases and its duration time increases in patients in long-term statin therapy.

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Interaction between rosuvastatin and rocuronium in rat sciatic-gastrocnemius nerve-muscle preparation

Abstract: The neuromuscular blocking potency of rocuronium is increased and recovery is delayed in rats that pre-treated with rosuvastatin.

Cited by 2 publications

References 23 publications

Rosuvastatin for enhancement of aneurysm neck endothelialization after coil embolization: promotion of endothelial progenitor cells in a rodent model

Rosuvastatin for enhancement of aneurysm neck endothelialization after coil embolization: promotion of endothelial progenitor cells in a rodent model

Neuromuscular Effects of Rocuronium Bromide in Patients in Statin Therapy for at least Three Months

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