Interaction between parathyroid hormone and the β-adrenoceptor system in cultured rat myocardial cells

Larno, S; Lhoste, F; Auclair, Marie-Claude; Lechat, P

doi:10.1016/0022-2828(80)90024-3

Cited by 15 publications

(3 citation statements)

References 16 publications

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“…PTH was shown to exert a potent chronotropic effect on neonatal cardiomyocytes via activation of L-type calcium channels (51). In the adult myocardium, it increases calcium influx into the cells with no direct contractile effect (52,53).…”

Section: Discussionmentioning

confidence: 99%

Use of recombinant human parathyroid hormone in hypocalcemic cardiomyopathy

Ballane

Sfeir

Dakik³

et al. 2012

European Journal of Endocrinology

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Hypocalcemia secondary to hypoparathyroidism is a rare cause of congestive heart failure. However, its early recognition and treatment lead to significant improvement in cardiac function. We report a middle-aged woman presenting with symptoms of heart failure with a serum calcium level of 3.7 mg/dl and a serum inorganic phosphate level of 17.6 mg/dl 22 years after subtotal thyroidectomy. Besides calcium and calcitriol supplementation, she was the first patient with severe hypocalcemic cardiomyopathy to be given off-label recombinant human parathyroid hormone (PTH) because of an elevated serum calcium–phosphate product. We discuss the management and outcome of the patient and then present a brief review of similar previously reported cases. We also describe the pivotal role of calcium ion and the potential role of PTH in maintaining myocardial contractility, effective natriuresis, and possible pathogenic mechanisms contributing to heart failure secondary to hypocalcemia and hypoparathyroidism.

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Section: Discussionmentioning

confidence: 99%

Use of recombinant human parathyroid hormone in hypocalcemic cardiomyopathy

Ballane

Sfeir

Dakik³

et al. 2012

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…There is no doubt that myocardial cells are targets for PTH. PTH has a definite positive chronotropic effect on rat myocardial cells ( 13–15). This effect seems to be due to enhancement of calcium influx into these cells via the indirect activation of specific calcium channels by PTH ( 16).…”

Section: In Vitro and Animal Model Evidence Implicating Pth In Cardiamentioning

confidence: 99%

“…A direct effect of PTH on myocardial contractility has not been demonstrated in human adult myocytes, but the cellular influx of calcium induced by PTH has been shown to increase contractility in animal cells ( 15, 22). On the other hand, PTH indirectly reduces myocardial contractility by interfering with β‐adrenoceptor‐mediated contractile effects ( 14, 23). Again, the clinical significance of these effects is not known.…”

Section: In Vitro and Animal Model Evidence Implicating Pth In Cardiamentioning

confidence: 99%