Interaction between paired-pulse facilitation and long-term potentiation during the stimulation of the cannabinoid and vanilloid systems in the dentate gyrus

Tahmasebi, Lida; Komaki‬, Alireza; Karamian, Ruhollah; Shahidi, Siamak; Sarihi, Abdolrahman; Komaki, Hamidreza

doi:10.1016/j.brainres.2016.04.058

Cited by 19 publications

(8 citation statements)

References 75 publications

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“…Synaptic plasticity in the hippocampal neurons involves in the memory formation (4). Several agents as well as neurotransmitters such cholinergic, glutamatergic, serotonergic, GABAerigic, vanilloid, cannabinoid systems influence the hippocampal synaptic plasticity and learning and memory (3, 60, 61). In the AD, memory impairments are due to the hippocampal neurodegeneration, imbalance of neurotransmitter systems and apoptosis in neurons (14, 62, 63).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of 5-HT1A Receptor Inhibition and 5-HT2A Receptor Stimulation Against Streptozotocin-Induced Apoptosis in the Hippocampus

Shahidi

Hashemi-Firouzi

Afshar

et al. 2019

MJMS

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Introduction Intracerebroventricular administration of streptozotocin (icv-STZ) induced apoptosis changes in neurons similar to Alzheimer’s disease. The serotonergic system via its receptor involved in survival of neurons. The present study examined the ability of selective 5-HT1A receptor antagonist (NAD-299) and 5-HT2A receptor agonist (TCB-2) to attenuate the apoptosis caused by the icv-STZ in the rat. Methods The icv-STZ (3 mg/kg, 10 μL, twice) induced neuronal loss in the hippocampus of adult male rats. Animals were divided into naive control, sham-operated, STZ+saline (1 μL, icv), STZ+NAD-299 (5 μg/μL, icv), STZ+TCB-2 (5 μg/μL, icv), and STZ+NAD-299+TCB-2 (5 μg/μL of any agent, icv) groups. Following the 35 days’ treatment period, neuronal apoptosis was detected using the Tunnel. Cells with morphological features of apoptotic cell were contended by microscopy. Results TCB-2 and NAD-299 administration decreased number of apoptotic neurons in the treatment group compared with the STZ group. Combined treatment of STZ rat with NAD+TCB more decreased number of apoptotic cells in compare to TCB-2 or NAD-299 treated STZ groups. Conclusion Treatment with 5-HT1A receptor antagonist or 5-HT2A receptor agonist diminished apoptosis. The beneficial effect of 5HT1A receptor inhibition was potentiated with activation of 5-HT2A receptor in prevention of apoptosis in hippocampus.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of 5-HT1A Receptor Inhibition and 5-HT2A Receptor Stimulation Against Streptozotocin-Induced Apoptosis in the Hippocampus

Shahidi

Hashemi-Firouzi

Afshar

et al. 2019

MJMS

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“…Glutamatergic transmission plays a crucial role in the experimental induction of LTP and a decrease in glutamate release taking place during HFS may prevent or attenuate LTP, and may affect learning and memory 12 , 13 . There is a large body of evidence reporting the impairing effect of exogenous cannabinoids on the induction of hippocampal LTP 10 , 14 – 16 . In line with this evidence, we found that the dose of WIN capable of reducing epileptiform activity also dramatically impaired the induction of LTP through a CB1 receptor-dependent mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…However, it has been widely reported that exogenous natural and synthetic cannabinoids negatively affect memory processes and alter physiological synaptic plasticity in memory-related brain regions 9 – 11 . Long term potentiation (LTP) of excitatory transmission is widely accepted as a cellular basis of hippocampus-dependent memory 12 , 13 and in vitro and in vivo studies have demonstrated that exogenous activation of CB1 receptor negatively affects the induction of hippocampal LTP 10 , 14 – 16 .…”

Section: Introductionmentioning

confidence: 99%

The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity

Colangeli

Pierucci

Benigno

et al. 2017

Sci Rep

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Synthetic cannabinoids and phytocannabinoids have been shown to suppress seizures both in humans and experimental models of epilepsy. However, they generally have a detrimental effect on memory and memory-related processes. Here we compared the effect of the inhibition of the endocannabinoid (eCB) degradation versus synthetic CB agonist on limbic seizures induced by maximal dentate activation (MDA) acute kindling. Moreover, we investigated the dentate gyrus (DG) granule cell reactivity and synaptic plasticity in naïve and in MDA-kindled anaesthetised rats. We found that both the fatty acid amide hydrolase (FAAH) inhibitor URB597 and the synthetic cannabinoid agonist WIN55,212-2 displayed AM251-sensitive anti-seizure effects. WIN55,212-2, dose-dependently (0.5–2 mg/kg, i.p.) impaired short-term plasticity (STP) and long-term potentiation (LTP) at perforant path-DG synapses in naïve rats. Strikingly, URB597 (1 mg/kg, i.p.) was devoid of any deleterious effects in normal conditions, while it prevented seizure-induced alterations of both STP and LTP. Our evidence indicates that boosting the eCB tone rather than general CB1 activation might represent a potential strategy for the development of a new class of drugs for treatment of both seizures and comorbid memory impairments associated with epilepsy.

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“…After HFS, EPSP and PS were registered at 5, 30, and 60 min for assigned alterations into the synaptic response of the DG neurons. For every time point, ten sequential provoked results were averaged at 10 s stimulus intervals [53,54]. The single pulses of the post-LTP burst were the same type as those for the I/O curve.…”

Section: High-frequency Stimulation For Ltp Inductionmentioning

confidence: 99%

Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats

et al. 2020

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High-fat diet (HFD) can induce deficits in neural function, oxidative stress, and decrease hippocampal neurogenesis. Hypericum (H.) scabrum extract (Ext) contains compounds that could treat neurological disorders. This study aimed to examine the neuroprotective impacts of the H. scabrum Ext on hippocampal synaptic plasticity in rats that were fed HFD. Fifty-four male Wistar rats (220 ± 10 g) were randomly arranged in six groups: (1) HFD group; (2) HFD + Ext300 group; (3) HFD + Ext100 group; (4) Control group; (5) Ext 300 mg/kg group; (6) Ext 100 mg/kg group. These protocols were administrated for 3 months. After this stage, a stimulating electrode was implanted in the perforant pathway (PP), and a bipolar recording electrode was embedded into the dentate gyrus (DG). Long-term potentiation (LTP) was provoked by high-frequency stimulation (HFS) of the PP. Field excitatory postsynaptic potentials (EPSP) and population spikes (PS) were recorded at 5, 30, and 60 min after HFS. The HFD group exhibited a large and significant decrease in their PS amplitude and EPSP slope as compared to the control and extract groups. In reverse, H. scabrum administration in the HFD + Ext rats reversed the effect of HFD on the PS amplitude and EPSP slope. The results of the study support that H. scabrum Ext can inhibit diminished synaptic plasticity caused by the HFD. These effects are probably due to the extreme antioxidant impacts of the Ext and its capability to scavenge free radicals.

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Interaction between paired-pulse facilitation and long-term potentiation during the stimulation of the cannabinoid and vanilloid systems in the dentate gyrus

Cited by 19 publications

References 75 publications

Protective Effects of 5-HT1A Receptor Inhibition and 5-HT2A Receptor Stimulation Against Streptozotocin-Induced Apoptosis in the Hippocampus

Protective Effects of 5-HT1A Receptor Inhibition and 5-HT2A Receptor Stimulation Against Streptozotocin-Induced Apoptosis in the Hippocampus

The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity

Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats

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